公开(公告)号：US20240192117A1

公开(公告)日：2024-06-13

申请号：US18185802

申请日：2023-03-17

Applicant: Hangzhou ShineDo Biotech. Co.Ltd.

Inventor： Yu XU ,  Zhiyuan MA ,  Xin LI ,  Jianqiu FANG ,  Chunmei ZHONG

IPC: G01N15/14 ,  G01N15/10

CPC classification number: G01N15/1463 ,  G01N15/1012 ,  G01N2015/1025

Abstract: A method for analyzing flow matrix data includes: acquiring and sampling a forward-scattered light pulse signal outputted by a flow matrix analyzer and a plurality of fluorescence pulse signals; performing fluorescence compensation on three pieces of fluorescence pulse data after the sampling, and mapping true data of two classification fluorescence pulses to a scatter plot so as to form a two-dimensional array; converting the two-dimensional array into a binary image, and constructing an ellipse gate related to the gathering region; obtaining intrinsic characteristics and movement characteristics of the ellipse gate; and obtaining coordinates of two focuses on the ellipse gate; calculating a distance between each microsphere particle and the two focuses on each ellipse gate; and calculating a median value of true data of calibration fluorescence pulses on all microsphere particles.

公开(公告)号：US11921101B2

公开(公告)日：2024-03-05

申请号：US17648887

申请日：2022-01-25

Applicant: Bonraybio Co., Ltd.

Inventor： Cheng-Teng Hsu ,  Chih-Pin Chang ,  Kuang-Li Huang ,  Yu-Chiao Chi ,  Chia-Wei Chang ,  Chiung-Han Wang

IPC: G01N33/48 ,  G01N1/28 ,  G01N15/10 ,  G01N15/14 ,  G01N21/17 ,  G06T7/00 ,  G06T7/11 ,  G06T7/80 ,  G06T7/90 ,  H04N23/58 ,  H04N23/67 ,  G01N15/00 ,  H04N23/57

CPC classification number: G01N33/48 ,  G01N1/2806 ,  G01N15/1012 ,  G01N15/1429 ,  G01N15/1463 ,  G01N21/17 ,  G06T7/0014 ,  G06T7/11 ,  G06T7/80 ,  G06T7/90 ,  H04N23/58 ,  H04N23/67 ,  G01N2015/0065 ,  G01N2015/1075 ,  G01N2015/1486 ,  G01N2021/177 ,  G06T2207/30168 ,  H04N23/57

Abstract: Disclosed are calibration techniques that can be implemented by a device that conducts biological tests. In certain embodiments, the device for testing a biological specimen includes a receiving mechanism to receive a carrier, a camera module arranged to capture imagery of the carrier, and a processor. Some examples of the processor can detect a calibration mode trigger. In calibration mode, the processor can divide the captured imagery into segments and selectively perform one or more calibration procedures for each segment. Then, the processor records a calibration result for each segment.

公开(公告)号：US11920122B2

公开(公告)日：2024-03-05

申请号：US17718570

申请日：2022-04-12

Applicant: Thrive Bioscience, Inc.

Inventor： Alan Blanchard

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  G01N15/14 ,  G01N35/00 ,  G01N15/10 ,  G01N35/04

CPC classification number: C12M41/14 ,  C12M41/36 ,  C12M41/40 ,  C12M41/48 ,  G01N15/1463 ,  G01N35/00732 ,  G01N35/0099 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2035/00356 ,  G01N2035/0463

Abstract: A cell culture incubator with an incubator cabinet has an internal chamber with a door opening from an external environment. An imager and a manipulator with a scraper are in the internal chamber. A controller is configured for controlling the manipulator to modulate the contact pressure between a scraping edge of the cell scraper and a surface of a cell culture vessel and a sensor is connected to the cell scraper that provides signal to the controller informative of a sensed pressure between a scraping edge of the cell scraper and the surface of a cell culture vessel. The controller controls the manipulator to increase or decrease the pressure between a scraping edge of the cell scraper and the surface of a cell culture vessel.

公开(公告)号：US11899007B2

公开(公告)日：2024-02-13

申请号：US17648901

申请日：2022-01-25

Applicant: Bonraybio Co., Ltd.

Inventor： Cheng-Teng Hsu ,  Chih-Pin Chang ,  Kuang-Li Huang ,  Yu-Chiao Chi ,  Chia-Wei Chang ,  Chiung-Han Wang

IPC: G01N33/48 ,  G01N1/28 ,  G01N21/17 ,  G06T7/80 ,  G06T7/11 ,  G06T7/90 ,  G01N15/10 ,  G01N15/14 ,  G06T7/00 ,  H04N23/58 ,  H04N23/67 ,  G01N15/00 ,  H04N23/57

CPC classification number: G01N33/48 ,  G01N1/2806 ,  G01N15/1012 ,  G01N15/1429 ,  G01N15/1463 ,  G01N21/17 ,  G06T7/0014 ,  G06T7/11 ,  G06T7/80 ,  G06T7/90 ,  H04N23/58 ,  H04N23/67 ,  G01N2015/0065 ,  G01N2015/1075 ,  G01N2015/1486 ,  G01N2021/177 ,  G06T2207/30168 ,  H04N23/57

Abstract: Disclosed are verification techniques that can be implemented by a device that conducts biological tests to verify that the specimen holding area carries a valid biological specimen. In certain embodiments, the testing device includes a receiving mechanism to receive a carrier, and the carrier includes a holding area that is to carry or to be exposed to a biological specimen. The device can also include a camera module arranged to capture imagery of the carrier, and a processor. In some examples, the processor can capture the imagery of the carrier and identify a visual cue on the carrier. Then, the processor can verify, based on a manner of how the visual cue is displayed in the captured imagery, whether the holding area carries a valid biological specimen.

公开(公告)号：US20240027327A1

公开(公告)日：2024-01-25

申请号：US18224937

申请日：2023-07-21

Applicant: BECKMAN COULTER, INC.

Inventor： Eduardo DELGADO ,  Bart WANDERS ,  Carol QUON ,  Gabriel SANTOS ,  John MCDONALD

IPC: G01N15/14 ,  G01N1/31

CPC classification number: G01N15/1436 ,  G01N1/31 ,  G01N15/1463 ,  G01N2015/144 ,  G01N2015/008

Abstract: A biological imaging analyzer is described comprises a staining module configured to stain cells of a biological sample so as to produce stained cells. The analyzer also comprises a lighting module configured to illuminate the stained cells, the lighting module comprising a plurality of pulsed lights. The analyzer further comprises an imaging module configured to capture images of the stained cells. A method of flow imaging a biological sample comprises flowing the biological sample including the stained cells through an image capture region of a flowcell. The method also comprises utilizing the lighting module to illuminate the stained cells at the image capture region with the plurality of pulsed lights. The method further comprises capturing images of the stained cells at the image capture region with the imaging module.

公开(公告)号：US11698331B1

公开(公告)日：2023-07-11

申请号：US17124230

申请日：2020-12-16

Applicant: Scanit Technologies, Inc.

Inventor： Pedro Manautou ,  Joel Kent ,  An-Chun Tien

IPC: G01N15/06 ,  G01N15/14 ,  G01N33/49 ,  G01N35/00 ,  G01N1/22 ,  G01N15/02 ,  G06V20/69 ,  G01N1/24 ,  G01N15/00

CPC classification number: G01N15/0612 ,  G01N1/2273 ,  G01N15/0227 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/4925 ,  G01N35/00871 ,  G06V20/693 ,  G01N2001/2276 ,  G01N2001/245 ,  G01N2015/0065 ,  G01N2015/1465 ,  G01N2015/1486 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2035/009 ,  G01N2035/00881

Abstract: An airborne biological particle monitoring device collects particles floating in air. The monitoring device includes a processor, a camera sensor, and a set of approximately monochromatic illumination sources that correspond to a set of spectral curves. The camera sensor captures images of the particles providing a spectral analysis of the particles. The processor analyzes the images to identify the collected particles.

公开(公告)号：US11692927B2

公开(公告)日：2023-07-04

申请号：US17295562

申请日：2019-11-20

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding

IPC: G01N33/543 ,  G01N15/14 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/1463 ,  G01N33/54306 ,  G01N2015/008 ,  G01N2015/0038 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2333/4737

Abstract: The present invention provides diagnostic devices and methods for quantifying the amounts of an acute phase reactant (e.g., C-reactive protein (CRP) or serum amyloid A (SAA)) in a body fluid sample and/or white blood cell counts in blood sample. In particular, the present invention provides a rapid assay to detect CRP, SAA, and/or white blood cells in blood with high sensitivity and specificity.

公开(公告)号：US20230152203A1

公开(公告)日：2023-05-18

申请号：US17984116

申请日：2022-11-09

Applicant: Iris International, Inc.

Inventor： Thomas H. Adams ,  Bart J. Wanders ,  John Roche ,  Harvey L. Kasdan

IPC: G01N15/14 ,  G01N33/50 ,  G01N15/06 ,  G01N21/53 ,  G02B7/36 ,  G01N33/80 ,  G01N1/30 ,  G01N33/49

CPC classification number: G01N15/1404 ,  G01N33/5094 ,  G01N15/06 ,  G01N15/1468 ,  G01N15/1434 ,  G01N15/147 ,  G01N15/1463 ,  G01N15/1475 ,  G01N21/53 ,  G01N15/1459 ,  G01N15/1429 ,  G01N15/1436 ,  G02B7/36 ,  G01N33/5091 ,  G01N33/80 ,  G01N1/30 ,  G01N33/49 ,  G01N33/4915 ,  G01N2015/1452 ,  G01N2015/0065

Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

公开(公告)号：US20180348196A1

公开(公告)日：2018-12-06

申请号：US16102036

申请日：2018-08-13

Applicant: Abbott Point of Care, Inc.

Inventor： Min Xie ,  Stephen C. Wardlaw

IPC: G01N33/49 ,  G01N15/14 ,  G06K9/00 ,  G01N15/02 ,  G01N21/64 ,  G01N33/483 ,  G01N15/00

CPC classification number: G01N33/49 ,  G01N15/0227 ,  G01N15/1463 ,  G01N21/6458 ,  G01N33/483 ,  G01N2015/0065 ,  G06K9/00127 ,  G06K9/00134 ,  G06K9/0014

Abstract: A method for analyzing a biologic fluid sample includes the steps of: a) providing a spatially mapped chamber; b) providing a predetermined repeatable non-uniform spatial distribution of one or more constituents within the sample, which distribution indicates the presence or absence of a statistically significant number of constituents within the sample in each chamber sub-region; c) selecting one or more image techniques for each sub-region based on the presence or absence of the statistically significant number of one or more constituents in that sub-region as indicated by the distribution; d) creating image data representative of the biologic fluid sample in each sub-region, using the one or more image techniques selected for that sub-region; and e) analyzing the sample.

公开(公告)号：US20180275043A1

公开(公告)日：2018-09-27

申请号：US15958480

申请日：2018-04-20

Applicant: EMD Millipore Corporation

Inventor： Philip Janmin Lee ,  Paul Ju-Sung Hung ,  Narendra Maheshri

IPC: G01N15/14 ,  B01L3/00 ,  G01N33/487 ,  G01N33/543 ,  G01N15/00

CPC classification number: G01N15/1484 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0867 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/147 ,  G01N15/1475 ,  G01N33/487 ,  G01N33/54366 ,  G01N2015/0065 ,  G01N2015/1493

Abstract: The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.