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    PLAQUE DETECTION METHOD FOR IMAGING OF CELLS
    3.
    发明公开
    PLAQUE DETECTION METHOD FOR IMAGING OF CELLS 审中-公开

    公开(公告)号：US20240095910A1

    公开(公告)日：2024-03-21

    申请号：US18275171

    申请日：2022-02-01

    申请人： Thrive Bioscience, Inc.

    发明人： Kenneth CHAPMAN ,  Frank EVANS

    IPC分类号： G06T7/00 ,  G06T7/11

    CPC分类号： G06T7/0012 ,  G06T7/11 ,  G06T2207/30024

    摘要： A plaque detection method and apparatus wherein at least one processor is programmed to receive above focus images to detect the presence of live cells without detecting the lysed cell materials, receive below focus images wherein virtual dark regions exist which are similar to cell shadows as seeds in a segmentation process and use contours around each resulting shape to obtain a subset that are more likely to be part of the cell population to define a cell map. A distance map is created in which each pixel value is the distance of that pixel from the nearest pixel of the cell map and the distance map is thresholded to create a first image of the places which are relatively far from the cells a second image with a smaller distance threshold to get an image that mimics the edges of the cells.

    LIQUID TRANSFER SYSTEM
    5.
    发明公开
    LIQUID TRANSFER SYSTEM 审中-公开

    公开(公告)号：US20230321647A1

    公开(公告)日：2023-10-12

    申请号：US18333495

    申请日：2023-06-12

    申请人： Thrive Bioscience, Inc.

    发明人： Alan Blanchard

    IPC分类号： B01L3/02 ,  C12M1/26 ,  C12M1/00 ,  C12M1/34

    CPC分类号： B01L3/0275 ,  C12M33/04 ,  C12M41/14 ,  C12M41/40 ,  B01L2200/0689 ,  B01L2300/123 ,  B01L2400/0481

    摘要： Aspects of the invention relate to liquid transfer systems including a pipette tip having a body defining an inner volume and having first and second ends, the first end arranged to transfer a volume of liquid into and out of the pipette tip and the second end arranged for attachment to a pipette, and a bladder sealingly attached to the body. In some embodiments, the bladder is disposable in the inner volume. The bladder may be defined by a membranous sac and/or a planar membrane. The bladder may be moveable in response to an applied pressure to transfer liquid. The bladder also may be stretchable to accommodate a volume of fluid. In some embodiments, the pipette tip is used in a cell culture incubator, with a manipulator including a pipette that is in fluid communication with the pipette tip.

    AUTOMATED APPARATUS AND METHOD FOR IN VITRO FERTILIZATION
    6.
    发明公开
    AUTOMATED APPARATUS AND METHOD FOR IN VITRO FERTILIZATION 审中-公开

    公开(公告)号：US20230303959A1

    公开(公告)日：2023-09-28

    申请号：US18326911

    申请日：2023-05-31

    申请人： Thrive Bioscience, Inc.

    发明人： Alan Blanchard

    IPC分类号： C12M1/00 ,  C12M1/34 ,  G01N15/14 ,  C12M1/36 ,  G01N35/00

    CPC分类号： C12M41/14 ,  C12M41/36 ,  C12M41/40 ,  C12M41/48 ,  G01N15/1463 ,  G01N35/00732 ,  G01N35/0099 ,  G01N2015/1006

    摘要： A method and apparatus for incubating sperm, eggs, and/or embryos for in vitro fertilization placing at least one of sperm, eggs, and embryos in at least one cell culture vessel in an incubator chamber having windows with filters to filter out ultraviolet light, wherein interior surfaces of the chamber comprises material that prevents the growth of fungus, and wherein the chamber includes sensors for regulating the levels of oxygen, carbon dioxide and nitrogen in the chamber, transporting the at least one cell culture vessel from a storage location in the chamber to an imager at an imaging location in the chamber using an elevator; and repeatedly imaging at least one of the sperm, eggs, and the embryos in the imager while maintaining the levels of oxygen, carbon dioxide and nitrogen throughout the chamber.

    Method and system for cell operations using a blockchain data network
    7.
    发明申请
    Method and system for cell operations using a blockchain data network 有权

    公开(公告)号：US20220382781A1

    公开(公告)日：2022-12-01

    申请号：US17684369

    申请日：2022-03-01

    申请人： Thrive Bioscience, Inc.

    发明人： Howard Cannon ,  Thomas Forest Farb

    IPC分类号： G06F16/27 ,  G06F21/62 ,  G06F16/907

    摘要： A method and system for performing operations on cells on an instrument comprises providing a peer to peer network of instruments for performing operations on cells, maintaining a distributed database in at least a plurality of the instruments in the peer to peer network, storing at least one protocol in the database for use by at least one instrument in the peer to peer network for performing operations on cells and storing results from the performance of the operations on cells by the at least one instrument in the distributed database. The results stored in the distributed database is then usable to later authenticate the results from the at least one instrument.

    AUTOMATED CELL CULTURE INCUBATOR
    8.
    发明申请
    AUTOMATED CELL CULTURE INCUBATOR 有权

    公开(公告)号：US20220259546A1

    公开(公告)日：2022-08-18

    申请号：US17688132

    申请日：2022-03-07

    申请人： Thrive Bioscience, Inc.

    发明人： Alan Blanchard

    IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/36

    摘要： Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.