公开(公告)号：US11319523B2

公开(公告)日：2022-05-03

申请号：US15563370

申请日：2016-03-31

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/36

摘要： Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.

公开(公告)号：US20180087020A1

公开(公告)日：2018-03-29

申请号：US15563370

申请日：2016-03-31

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/36

CPC分类号： C12M41/14 ,  C12M33/00 ,  C12M37/00 ,  C12M41/48

摘要： Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.

公开(公告)号：US20180079999A1

公开(公告)日：2018-03-22

申请号：US15563360

申请日：2016-03-31

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/12 ,  C12M1/00 ,  C12M3/06 ,  C12M1/04 ,  C12M1/36 ,  C12M1/34

CPC分类号： C12M37/04 ,  C12M23/06 ,  C12M23/16 ,  C12M23/24 ,  C12M23/28 ,  C12M23/44 ,  C12M23/50 ,  C12M29/00 ,  C12M33/00 ,  C12M37/00 ,  C12M37/02 ,  C12M41/14 ,  C12M41/36 ,  C12M41/46 ,  C12M41/48 ,  C12M47/04

摘要： In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.

公开(公告)号：US11879120B2

公开(公告)日：2024-01-23

申请号：US17490992

申请日：2021-09-30

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/12 ,  C12M3/06 ,  C12M1/04 ,  C12M3/00 ,  C12M1/26 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12M3/02

CPC分类号： C12M37/04 ,  C12M3/02 ,  C12M23/06 ,  C12M23/16 ,  C12M23/24 ,  C12M23/28 ,  C12M23/44 ,  C12M23/50 ,  C12M29/00 ,  C12M33/00 ,  C12M37/00 ,  C12M41/14 ,  C12M41/36 ,  C12M41/46 ,  C12M41/48 ,  C12M47/04

摘要： In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.

公开(公告)号：US20220403314A1

公开(公告)日：2022-12-22

申请号：US17890876

申请日：2022-08-18

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/00 ,  C12M1/06 ,  C12N5/078

摘要： Aspects of the invention relate to cell culture vessels and method for using the vessels to agitate and maintain cells in suspension. In some embodiments, the vessel has a body configured to hold a volume of liquid containing cells to be cultured, the vessel body having a deformable portion arranged to induce movement of the liquid sufficient to maintain the cells in suspension. In some embodiments, the deformable portion is in at least one of a base and sidewall of the vessel body. In some embodiments, the deformable portion is deformed according to a deformable pattern. In some embodiments, the deformable portion is deformed via a deformation plate having one or more movable members that contact the deformable portion.

公开(公告)号：US20210261899A1

公开(公告)日：2021-08-26

申请号：US17316672

申请日：2021-05-10

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/04 ,  C12M1/12 ,  C12M1/00 ,  C12M1/22 ,  C12M1/34 ,  C12M3/00

摘要： In some aspects, the invention relates to selectively permeable cell culture vessel storage containers and their methods of use. In some embodiments, the containers comprise a gas-permeable membrane that is selectively impermeable to water vapor.

公开(公告)号：US20210214665A1

公开(公告)日：2021-07-15

申请号：US16093129

申请日：2017-04-12

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/00 ,  C12M1/06 ,  C12N5/078

摘要： Aspects of the invention relate to cell culture vessels and method for using the vessels to agitate and maintain cells in suspension. In some embodiments, the vessel has a body configured to hold a volume of liquid containing cells to be cultured, the vessel body having a deformable portion arranged to induce movement of the liquid sufficient to maintain the cells in suspension. In some embodiments, the deformable portion is in at least one of a base and sidewall of the vessel body. In some embodiments, the deformable portion is deformed according to a deformable pattern. In some embodiments, the deformable portion is deformed via a deformation plate having one or more moveable members that contact the deformable portion.

公开(公告)号：US20240309308A1

公开(公告)日：2024-09-19

申请号：US18430569

申请日：2024-02-01

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  G01N15/10 ,  G01N15/1433 ,  G01N15/1434 ,  G01N35/00 ,  G01N35/04

CPC分类号： C12M41/14 ,  C12M41/36 ,  C12M41/40 ,  C12M41/48 ,  G01N15/1433 ,  G01N35/00732 ,  G01N35/0099 ,  G01N2015/1006 ,  G01N2015/1454 ,  G01N2035/00356 ,  G01N2035/0463

摘要： Aspects of the invention relate to automated cell culture incubators. In some embodiments, automated cell culture incubators comprise an integrated manipulation device having one or more cell scrapers.

公开(公告)号：US20240228936A1

公开(公告)日：2024-07-11

申请号：US18539249

申请日：2023-12-13

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： C12M1/12 ,  C12M1/00 ,  C12M1/04 ,  C12M1/26 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00 ,  C12M3/02 ,  C12M3/06

CPC分类号： C12M37/04 ,  C12M3/02 ,  C12M23/06 ,  C12M23/16 ,  C12M23/24 ,  C12M23/28 ,  C12M23/44 ,  C12M23/50 ,  C12M29/00 ,  C12M33/00 ,  C12M37/00 ,  C12M37/02 ,  C12M41/14 ,  C12M41/36 ,  C12M41/46 ,  C12M41/48 ,  C12M47/04

摘要： In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.

公开(公告)号：US20230321647A1

公开(公告)日：2023-10-12

申请号：US18333495

申请日：2023-06-12

申请人： Thrive Bioscience, Inc.

发明人： Alan Blanchard

IPC分类号： B01L3/02 ,  C12M1/26 ,  C12M1/00 ,  C12M1/34

CPC分类号： B01L3/0275 ,  C12M33/04 ,  C12M41/14 ,  C12M41/40 ,  B01L2200/0689 ,  B01L2300/123 ,  B01L2400/0481

摘要： Aspects of the invention relate to liquid transfer systems including a pipette tip having a body defining an inner volume and having first and second ends, the first end arranged to transfer a volume of liquid into and out of the pipette tip and the second end arranged for attachment to a pipette, and a bladder sealingly attached to the body. In some embodiments, the bladder is disposable in the inner volume. The bladder may be defined by a membranous sac and/or a planar membrane. The bladder may be moveable in response to an applied pressure to transfer liquid. The bladder also may be stretchable to accommodate a volume of fluid. In some embodiments, the pipette tip is used in a cell culture incubator, with a manipulator including a pipette that is in fluid communication with the pipette tip.