公开(公告)号：US20250035539A1

公开(公告)日：2025-01-30

申请号：US18919157

申请日：2024-10-17

Applicant: BECKMAN COULTER, INC.

Inventor： Michael KAPINSKY

IPC: G01N21/25 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1434

Abstract: Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.

公开(公告)号：US12210027B2

公开(公告)日：2025-01-28

申请号：US17671308

申请日：2022-02-14

Applicant: Beckman Coulter, Inc.

Inventor： Andras Guttman ,  Clarence Lew ,  Marton Szigeti ,  Csaba Varadi

IPC: G01N35/00 ,  C08B37/00

Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method using magnetic beads containing negatively charged carboxyl groups extending from the surface of the magnetic beads.

公开(公告)号：US12196745B2

公开(公告)日：2025-01-14

申请号：US17898910

申请日：2022-08-30

Applicant: Beckman Coulter, Inc.

Inventor： Jun Yang ,  Jon Tindel

IPC: G01N33/50 ,  G01N15/10 ,  G01N15/1404 ,  G01N15/1433 ,  G01N15/1434 ,  G01N33/96 ,  G06F3/048 ,  G06F16/50 ,  G06F18/22 ,  G06F18/40 ,  G06T5/77 ,  G06T7/00 ,  G06T11/00 ,  G06V10/44 ,  G06V10/75 ,  G06V10/94 ,  G06V20/69

Abstract: In some embodiments, a process and system are provided for generating a user interface for classification of a sample image of a cell that includes receiving a sample image of a sample particle from a biological sample and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity and the reference images can be selected based on the order. The first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.

公开(公告)号：US20250003524A1

公开(公告)日：2025-01-02

申请号：US18697864

申请日：2022-10-13

Applicant: Beckman Coulter, Inc.

Inventor： Masayuki Osako ,  Noriyuki Ito

IPC: F16K37/00 ,  G01N35/00

Abstract: Disclosed are systems and methods for detecting a malfunction in an automated analyzer. The systems and methods may include receiving a signal from a sensor (116), such as a Hall effect sensor located proximate a coil (104) of a solenoid valve (100). The signal from the sensor may be correlated to a magnetic flux or change in the magnetic flux generated as a plunger (102) of the solenoid valve is drawn into the coil when the coil is energized. Deviations in the signal from a reference may indicated a malfunction of the solenoid valve. Upon detecting a malfunction, a pre-failure status may be determined.

公开(公告)号：US20240418737A1

公开(公告)日：2024-12-19

申请号：US18817182

申请日：2024-08-27

Applicant: Beckman Coulter, Inc.

Inventor： Eric VARLET ,  Roland REICHLE

IPC: G01N35/00

Abstract: A computer-implemented method is provided. The method comprises: accessing, by a first computing device, sample-processing data, wherein the sample-processing data comprise information indicative of a set of procedures to be carried out on a biological sample, wherein each procedure comprises one or more actions; obtaining, by the first computing device, ALS1 state data, wherein the ALS1 state data comprise information indicative of a state of a first automated laboratory system-ALS1; obtaining, by the first computing device, ALS2 operation data, wherein the ALS2 operation data comprise information indicative of an ALS2 set of actions of at least a first procedure, wherein the ALS2 set of actions either has been carried out or is scheduled to be carried out by a second automated laboratory system-ALS2-on the biological sample; generating, by the first computing device, ALS1 processing data by using the sample-processing data, the ALS1 state data and the ALS2 operation data, wherein the ALS1 processing data comprise information indicative of an ALS1 set of actions of at least a second procedure of the sets of procedures; and initiating, by the first computing device, the generation of an ALS1 route plan for the first automated laboratory system, the ALS1 route plan being based on the ALS1 processing data.

公开(公告)号：US20240404302A1

公开(公告)日：2024-12-05

申请号：US18613413

申请日：2024-03-22

Applicant: Beckman Coulter, Inc.

Inventor： Joanna JOHNSON ,  Taylor GREGORY ,  Amit SAWHNEY ,  Takayuki MIZUTANI

IPC: G06V20/69 ,  G01N15/075 ,  G06T7/00 ,  G06V10/25

Abstract: The present disclosure provides a method (400) of evaluating a fluidic substance (10) having particles (11). The method (400) comprises capturing a reference image (202) of at least a portion of a container (102) that is in an empty state; determining a reference grayscale value (V1) of at least a portion of the reference image (202); aspirating a volume of the fluidic substance (10) into the container (102); capturing a test image (252) of the container (102) containing the aspirated volume of the fluidic substance (10); determining a test grayscale value (V2) of at least a portion of the test image (252); calibrating a universal calibration curve (56) relating particle concentration and grayscale value based on the reference and test grayscale values (V1, V2); and determining a particle concentration (P1) in the fluidic substance (10) based on the test grayscale value (V2) and the calibrated universal calibration curve (60).

公开(公告)号：US12135291B2

公开(公告)日：2024-11-05

申请号：US18225594

申请日：2023-07-24

Applicant: Beckman Coulter, Inc.

Inventor： Brian Kozicki ,  Creigh Thompson ,  Richard Wolf ,  Laura Holmes ,  David Sorrentino

IPC: G01N21/27 ,  G01J1/44 ,  G01N21/76

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

公开(公告)号：US20240361248A1

公开(公告)日：2024-10-31

申请号：US18661672

申请日：2024-05-12

Applicant: Beckman Coulter, Inc.

Inventor： Takayuki MIZUTANI ,  Amit SAWHNEY ,  Kevin Louis NOWAK ,  Laura Elizabeth Schilling HOLMES ,  Jessica Melissa Mattke TUBMAN

IPC: G01N21/65 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N21/658 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/1002 ,  G01N2035/00346 ,  G01N2201/06113

Abstract: The presently claimed and described technology provides systems and methods for determining concentration of an analyte of interest using Surface Enhanced Raman Spectroscopy (SERS). An automated SERS system can include a body for accepting a substrate, a fluid handling system, a light source, and a detector that collects and detects Raman scattered light.

公开(公告)号：US20240357232A1

公开(公告)日：2024-10-24

申请号：US18740301

申请日：2024-06-11

Applicant: Beckman Coulter, Inc.

Inventor： Jiuliu LU ,  Bian QIAN ,  John S. RILEY ,  Bart WANDERS ,  Ken GOOD

IPC: H04N23/67 ,  G01N15/01 ,  G01N15/1434 ,  G06T3/40 ,  G06T7/00

CPC classification number: H04N23/67 ,  G01N15/01 ,  G01N15/1436 ,  G06T3/40 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10148 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024

Abstract: A focusing distance (e.g., a distance between a focal plane of a camera used when n image was captured and the actual focal plane for an in-focus image) in a visual analysis system may be determined by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, an input may be subjected to one or more convolution filters, and the ultimate result of such convolution may be provided to a dense layer which can provide the focusing distance. This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).

公开(公告)号：US12106588B2

公开(公告)日：2024-10-01

申请号：US18594423

申请日：2024-03-04

Applicant: Beckman Coulter, Inc.

Inventor： Takayuki Mizutani ,  Katsuhiro Seo ,  Shigeru Fujii ,  Kazuki Umebara ,  MArie Willette ,  Leila Nazemi

IPC: G06V20/69 ,  C12M1/34 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50

CPC classification number: G06V20/69 ,  C12M41/46 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50 ,  G06T2207/10024 ,  G06T2207/30072

Abstract: Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.