公开(公告)号：US11505522B2

公开(公告)日：2022-11-22

申请号：US16894429

申请日：2020-06-05

申请人： Celgene Corporation

发明人： John F. Traverse ,  Michael J. Zacuto ,  Weihong Zhang ,  Kirsten Faye Johnson ,  Maryll E. Geherty ,  Christopher Marton

IPC分类号： C07C231/18 ,  C07C231/12 ,  C07C237/06 ,  C07D209/46 ,  C07C275/70 ,  C07C237/12 ,  C07C273/18 ,  C07C275/24 ,  C07C67/313 ,  C07C231/02

摘要： Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

公开(公告)号：US20220081385A1

公开(公告)日：2022-03-17

申请号：US17419939

申请日：2019-12-27

申请人： Lupin Limited

发明人： Navnath Ambadas Kadam ,  Rohidas Shivaji Sulake ,  Rajinder Singh Siyan ,  Nandu Baban Bhise ,  Girij Pal Singh ,  Rajesh Harishankar Vyas

IPC分类号： C07C67/313

摘要： The present invention relates to novel pharmaceutically acceptable salts of Bempedoic acid, novel intermediates of Bempedoic acid, novel crystalline form of Bempedoic acid and novel processes for the preparation of Bempedoic acid or its intermediates thereof.

公开(公告)号：US20210253510A1

公开(公告)日：2021-08-19

申请号：US16973134

申请日：2019-06-17

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Taku WATANABE

IPC分类号： C07C67/313

摘要： The present invention provides a method for producing a bifunctional compound having a norbornane skeleton, the method comprising a step of hydroformylating a compound having an olefin with carbon monoxide and hydrogen, wherein the molar ratio of the carbon monoxide to the hydrogen during the reaction is 55/45 or more and 95/5 or less in the hydroformylating step.

公开(公告)号：US20200299228A1

公开(公告)日：2020-09-24

申请号：US16894429

申请日：2020-06-05

申请人： Celgene Corporation

发明人： John F. Traverse ,  Michael J. Zacuto ,  Weihong Zhang ,  Kirsten Faye Johnson ,  Maryll E. Geherty ,  Christopher Marton

IPC分类号： C07C231/18 ,  C07C231/12 ,  C07C237/06 ,  C07D209/46 ,  C07C275/70 ,  C07C237/12 ,  C07C273/18 ,  C07C275/24 ,  C07C67/313 ,  C07C231/02

摘要： Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

公开(公告)号：US10544119B2

公开(公告)日：2020-01-28

申请号：US15309469

申请日：2014-08-04

申请人： Asymchem Laboratories (Tianjin) Co., Ltd. ,  Asymchem Life Science (Tianjin) Co., Ltd. ,  Tianjin Asymchem Pharmaceutical Co., Ltd. ,  Asymchem Laboratories (Fuxin) Co., Ltd. ,  Jilin Asymchem Laboratories Co., Ltd.

发明人： Hao Hong ,  Chaoyong Chen ,  Jiuyuan Li ,  Litao Shen ,  Lina Guo ,  Hongying Tian

IPC分类号： C07D319/06 ,  C12P7/62 ,  C07C51/367 ,  C07C67/30 ,  C07C67/313

摘要： The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, substitution, and asymmetric reduction. The preparation method provided in the present invention has a novel route of synthesis, allows an intermediate compound to be introduced conveniently into the chiral center of a glycol via enzyme reduction, and not only is low in costs, but also is reliable in quality. The route of synthesis provided in the present invention uses raw materials of low costs, has an easy to operate process, and provides a final product of great purity and high yield.

公开(公告)号：US10207984B2

公开(公告)日：2019-02-19

申请号：US15145323

申请日：2016-05-03

申请人： Emory University ,  Wake Forest University Health Sciences

发明人： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Thomas J. Martin ,  Steven R. Childers

IPC分类号： C07C229/46 ,  A61K31/195 ,  A61K45/06 ,  C07C227/16 ,  C07C67/313 ,  C07C69/757 ,  C07C227/04 ,  A61K31/216

摘要： The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.

公开(公告)号：US09732181B2

公开(公告)日：2017-08-15

申请号：US14964261

申请日：2015-12-09

申请人： International Business Machines Corporation

发明人： Scott B. King ,  Brandon M. Kobilka ,  Joseph Kuczynski ,  Jason T. Wertz

IPC分类号： C08G18/36 ,  C08G18/72 ,  C07C67/313 ,  C07C69/67 ,  G10K11/162 ,  C07C67/31 ,  C08G101/00

CPC分类号： C08G18/36 ,  C08G18/72 ,  C08G2101/00 ,  C08G2350/00 ,  C11C3/00 ,  G10K11/162

摘要： A process of forming a polyurethane material includes forming an alkyne-terminated triglyceride material from an unsaturated plant oil. The process also includes forming a hydroxyl-terminated polyol material from the alkyne-terminated triglyceride material. The process further includes polymerizing a mixture that includes the hydroxyl-terminated polyol material to form a polyurethane material.

公开(公告)号：US09561996B2

公开(公告)日：2017-02-07

申请号：US13378959

申请日：2010-06-21

申请人： Karla S. Colle ,  Jorg F. Weber ,  Allen D. Godwin

发明人： Karla S. Colle ,  Jorg F. Weber ,  Allen D. Godwin

IPC分类号： C07C45/68 ,  C07C51/235 ,  C07C67/03 ,  C07C67/08 ,  C07C67/313 ,  C07C67/343 ,  C08K5/10 ,  C08K5/101 ,  C07C45/72 ,  C07C49/78 ,  C07C49/86 ,  C07C65/34 ,  C07C69/76 ,  C07C69/738 ,  C07C69/82 ,  C08L27/06

CPC分类号： C07C67/03 ,  C07C45/68 ,  C07C45/72 ,  C07C49/78 ,  C07C49/86 ,  C07C51/235 ,  C07C65/34 ,  C07C67/08 ,  C07C67/313 ,  C07C67/343 ,  C07C69/738 ,  C07C69/76 ,  C07C69/82 ,  C08K5/10 ,  C08K5/101 ,  C08L27/06 ,  Y10T428/1334 ,  Y10T428/139 ,  Y10T442/2369

摘要： Resin plasticizers are produced by esterification of keto acids derived from acylation of aromatic compounds with cyclic anhydrides, and are particularly useful in making phthalate-free articles using PVC.

摘要翻译： 树脂增塑剂是通过芳族化合物与环状酸酐的酰化衍生的酮酸的酯化制得的，特别适用于使用PVC制造不含邻苯二甲酸酯的制品。

公开(公告)号：US09499469B2

公开(公告)日：2016-11-22

申请号：US14905645

申请日：2014-07-03

申请人： IHARA CHEMICAL INDUSTRY CO., LTD.

发明人： Shinki Tani ,  Minekazu Koga ,  Izumi Matsumoto

IPC分类号： C07C69/66 ,  C07C67/313

CPC分类号： C07C67/313 ,  C07C67/31 ,  C07C69/716 ,  C07C69/675

摘要： Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1) (in the formula, The each Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general formula (2) (in the formula, R has the same meaning as above), or a hydrate thereof.

公开(公告)号：US09428439B2

公开(公告)日：2016-08-30

申请号：US14149450

申请日：2014-01-07

申请人： Astex Therapeutics Ltd.

发明人： Martyn Frederickson ,  John Francis Lyons ,  Neil Thomas Thompson ,  Mladen Vinkovic ,  Brian John Williams ,  Andrew James Woodhead ,  Alison Jo-Anne Woolford

IPC分类号： C07D209/44 ,  C07C67/317 ,  C07C67/313 ,  C07C59/08 ,  C07C69/92 ,  C07C235/60

CPC分类号： C07C67/317 ,  C07C59/08 ,  C07C67/313 ,  C07C69/92 ,  C07C235/60 ,  C07D209/44

摘要： The invention provides an acid addition salt of a compound of the formula (1). Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogs thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analog.

摘要翻译： 本发明提供式（1）化合物的酸加成盐。 本发明还提供制备式（1）化合物及其烷基类似物的方法，用于该方法的新中间体和制备中间体的方法。 本发明还提供式（1）化合物及其乙基类似物的新的医学用途。