公开(公告)号：US20220081385A1

公开(公告)日：2022-03-17

申请号：US17419939

申请日：2019-12-27

申请人： Lupin Limited

发明人： Navnath Ambadas Kadam ,  Rohidas Shivaji Sulake ,  Rajinder Singh Siyan ,  Nandu Baban Bhise ,  Girij Pal Singh ,  Rajesh Harishankar Vyas

IPC分类号： C07C67/313

摘要： The present invention relates to novel pharmaceutically acceptable salts of Bempedoic acid, novel intermediates of Bempedoic acid, novel crystalline form of Bempedoic acid and novel processes for the preparation of Bempedoic acid or its intermediates thereof.

公开(公告)号：US10479776B2

公开(公告)日：2019-11-19

申请号：US15573082

申请日：2016-05-10

申请人： LUPIN LIMITED

发明人： Sachin Arun Sasane ,  Devendrakumar Paramsukh Varma ,  Rajesh Harishankar Vyas ,  Nandu Baban Bhise ,  Girij Pal Singh ,  Krishnat Hanmant Kumbhar

IPC分类号： C07D401/06

摘要： The present invention provides an improved process for the preparation of Efinaconazole in higher yield by the ring-opening addition reaction of epoxytriazole with 4-methylenepiperidine or its acid addition salt under mild conditions without using a large excess of 4-methylenepiperidine in the presence of an alkali or an alkaline earth metal halide.