- 专利标题： Process for the preparation of Efinaconazole
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申请号： US15573082申请日： 2016-05-10
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公开(公告)号： US10479776B2公开(公告)日： 2019-11-19
- 发明人: Sachin Arun Sasane , Devendrakumar Paramsukh Varma , Rajesh Harishankar Vyas , Nandu Baban Bhise , Girij Pal Singh , Krishnat Hanmant Kumbhar
- 申请人： LUPIN LIMITED
- 申请人地址： IN Mumbai
- 专利权人： LUPIN LIMITED
- 当前专利权人： LUPIN LIMITED
- 当前专利权人地址： IN Mumbai
- 代理机构： Merchant & Gould P.C.
- 优先权： IN1875/MUM/2015 20150512
- 国际申请： PCT/IB2016/052667 WO 20160510
- 国际公布： WO2016/181306 WO 20161117
- 主分类号： C07D401/06
- IPC分类号： C07D401/06
摘要：
The present invention provides an improved process for the preparation of Efinaconazole in higher yield by the ring-opening addition reaction of epoxytriazole with 4-methylenepiperidine or its acid addition salt under mild conditions without using a large excess of 4-methylenepiperidine in the presence of an alkali or an alkaline earth metal halide.
公开/授权文献
- US20180118714A1 PROCESS FOR THE PREPARATION OF EFINACONAZOLE 公开/授权日：2018-05-03
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