公开(公告)号：US20230202856A1

公开(公告)日：2023-06-29

申请号：US17919336

申请日：2021-04-20

申请人： PURAC BIOCHEM B.V.

发明人： Fesia Lestari LAKSMANA ,  Raymon FREDIANSYAH

IPC分类号： C01F5/10 ,  C07C59/08 ,  C07C51/02 ,  C12P7/56

CPC分类号： C01F5/10 ,  C07C59/08 ,  C07C51/02 ,  C12P7/56 ,  C01P2004/61 ,  C01P2004/62

摘要： A process for converting magnesium chloride into magnesium oxide having the steps of: subjecting a magnesium chloride solution to a spray drying step in a spray-drying apparatus at a temperature of 300-475° C., resulting in the formation of a spray-dried product having 10-80 wt. % magnesium oxide and 20-90 wt. % of the total of magnesium hydroxychloride and magnesium chloride, subjecting the product of the spray drying step to a roasting step in a roaster at a temperature of 600-900° C. in the presence of water, resulting in the formation of a product having at least 98 wt. % of MgO, and less than 2 wt. % of the total of magnesium hydroxychloride and magnesium chloride, wherein the percentages of MgO, magnesium hydroxychloride and magnesium chloride, are calculated on the total of MgO, magnesium hydroxychloride and magnesium chloride.

公开(公告)号：US20210030634A1

公开(公告)日：2021-02-04

申请号：US16882000

申请日：2020-05-22

申请人： Yale University

发明人： Yang Deng ,  Asiri Ediriwickrema ,  W. Mark Saltzman

IPC分类号： A61K8/02 ,  C08G83/00 ,  C07C59/06 ,  C07C59/08 ,  A61K31/4178 ,  A61K9/00 ,  A61K9/50 ,  A61K9/16 ,  A61K31/427 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/34 ,  A61K8/90 ,  A61Q17/04

摘要： Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

公开(公告)号：US10683254B2

公开(公告)日：2020-06-16

申请号：US13142062

申请日：2009-12-25

申请人： Kenji Sawai ,  Hideki Sawai ,  Takashi Mimitsuka ,  Ito Masateru ,  Katsushige Yamada ,  Kenji Kawamura ,  Shin-ichi Minegishi ,  Izumi Nakagawa ,  Tatsuya Nagano

发明人： Kenji Sawai ,  Hideki Sawai ,  Takashi Mimitsuka ,  Ito Masateru ,  Katsushige Yamada ,  Kenji Kawamura ,  Shin-ichi Minegishi ,  Izumi Nakagawa ,  Tatsuya Nagano

IPC分类号： C07C59/08 ,  B01D71/56 ,  C08G63/06 ,  C12P7/56 ,  C07C51/42 ,  B01D61/02

摘要： Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.

公开(公告)号：US10450548B2

公开(公告)日：2019-10-22

申请号：US14898948

申请日：2014-06-18

申请人： CALYSTA, INC.

发明人： Renee M. Saville ,  Sungwon Lee ,  Drew D. Regitsky ,  Sol M. Resnick ,  Joshua A. Silverman

IPC分类号： C12N1/20 ,  C12N9/04 ,  C12P7/56 ,  C07B59/00 ,  C07C59/08 ,  C12N15/74

摘要： The present disclosure provides non-naturally occurring c1 microorganisms useful for the production of lactate and related compositions, as well as methods for the biologically production of lactate. In specific embodiments, the present disclosure provides non-naturally occurring methanotrophic bacteria which are useful for producing lactate from c1 substrates.

公开(公告)号：US10272019B2

公开(公告)日：2019-04-30

申请号：US15309733

申请日：2015-05-11

申请人： Yale University

发明人： Yang Deng ,  Asiri Ediriwickrema ,  William M. Saltzman

IPC分类号： A61K8/02 ,  C08G83/00 ,  C07C59/06 ,  C07C59/08 ,  A61K9/50 ,  A61K31/4178 ,  A61K9/16 ,  A61K31/427 ,  A61K9/00 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/34 ,  A61K8/90 ,  A61Q17/04

摘要： Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (HPG). The HPG can be covalently bound to the one or more materials that form the core or coated thereon. The HPG coating can be modified to adjust the properties of the particles. For example, unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups on tissue or otherwise interact with tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HPG coated nanoparticles. In some embodiments, the particles include therapeutic, diagnostic, nutraceutical, and/or prophylactic agents such as those used as sunblock compositions.

公开(公告)号：US10160712B2

公开(公告)日：2018-12-25

申请号：US15548100

申请日：2016-12-07

申请人： CHINA UNIVERSITY OF MINING AND TECHNOLOGY

发明人： Jing Liang ,  Huihui Yang ,  Xianyong Wei ,  Zhimin Zong

IPC分类号： C07C51/21 ,  C07C65/21 ,  C07C55/02 ,  C07C55/14 ,  C07C57/03 ,  C07C59/01 ,  C07C59/08 ,  C07C63/06 ,  C07C63/307 ,  B01J31/04 ,  B01J31/02

摘要： A method of catalytic oxidation of a lignite using oxygen as an oxidant at atmospheric pressure is provided. The method includes the following steps, pulverizing the lignite to 200-mesh or less; drying the pulverized lignite at a temperature of 80° C. in vacuum for 10 h; weighing 0.5 g of the dried lignite and sequentially adding 10 ml of acetic acid, 0.5 mmol of a catalyst and 0.15-0.25 mmol of a cocatalyst into a round-bottom flask filled with the oxygen, keeping oxygen pressure at 0.1 MPa, reacting at a temperature of 80-120° C. for 4-12 h; using oxygen as the oxidant to catalytically oxidize the reacted lignite at an atmospheric pressure of 0.1 MPa; filtering after the reaction is finished; decompressing the filtrate to remove the acetic acid, adding a small amount of ethyl acetate to dissolve, and using an excess CH2N2/ether solution to esterify for 10 h at room temperature; and analyzing the esterified product through a gas chromatography-mass spectrometer.

公开(公告)号：US20180148400A1

公开(公告)日：2018-05-31

申请号：US15867975

申请日：2018-01-11

申请人： The Procter & Gamble Company

发明人： Jakob Albert ,  Peter Wasserscheid ,  Nicola Taccardi ,  Jens Nagengast ,  Matthias Kehrer ,  Julian Kadar ,  Dimitris Ioannis Collias

IPC分类号： C07C51/377 ,  C07C57/04 ,  C07C59/08 ,  C07C59/315

摘要： Methods for making acrylic acid, acrylic acid derivatives, or mixtures thereof by contacting a feed stream containing lactic acid, lactic acid derivatives, or mixtures thereof with a molten salt catalyst comprising an ionic liquid (IL) and an acid in liquid phase are provided.

公开(公告)号：US09777109B2

公开(公告)日：2017-10-03

申请号：US15102812

申请日：2014-12-09

申请人： FUTERRO S.A.

发明人： Christian Penu ,  Philippe Coszach ,  Marie-Astrid Feron ,  Arnaud Delrue

IPC分类号： C08G63/08 ,  C08G63/78 ,  C07C59/08

CPC分类号： C08G63/08 ,  C07C59/08 ,  C08G63/78

摘要： The present invention relates to an improved process for producing polylactide where the goal is to recover a maximum of useful matters in order to recycle without loss and so significantly improving the global yield of the production process of polylactide when starting from lactic acid.

公开(公告)号：US09604895B2

公开(公告)日：2017-03-28

申请号：US14912372

申请日：2014-09-05

申请人： PLAXICA LIMITED

发明人： Stephen Donegan ,  Philip James Goodier ,  Edward Leslie Marshall ,  Urvish Rameshchandra Pandya ,  Ajitkumar Mukundrai Patel

IPC分类号： C07C59/08 ,  C07C51/02 ,  C01B7/03 ,  C07C67/08 ,  C07C51/295 ,  C07C51/41 ,  C01D1/04 ,  C01D3/04 ,  A61K35/744 ,  A01N63/02

CPC分类号： C07C51/02 ,  A01N63/02 ,  A61K35/744 ,  C01B7/03 ,  C01D1/04 ,  C01D3/04 ,  C07C51/295 ,  C07C51/41 ,  C07C59/08 ,  C07C67/08 ,  C07C69/68

摘要： A process for producing lactic acid is provided. The process comprises (a) reacting a stream rich in saccharide with sodium hydroxide in the presence of water to produce a reaction mixture comprising sodium lactate; (b) reacting at least a portion of the sodium lactate with HCl to produce lactic acid and sodium chloride; (c) converting at least a portion of the sodium chloride to chlorine and sodium hydroxide; and (d) recycling at least a portion of the sodium hydroxide produced in step (c) to step (a). Also provided are processes for the production of alkyl lactate, oligomeric lactic acid, lactide, alkyl lactyllactate, poly-lactic acid, propylene glycol and acrylic acid.

公开(公告)号：US09120727B2

公开(公告)日：2015-09-01

申请号：US13699589

申请日：2011-05-23

申请人： Rosemarie Riedl ,  Werner Heilmayer ,  Lee Spence

发明人： Rosemarie Riedl ,  Werner Heilmayer ,  Lee Spence

IPC分类号： C07C205/00 ,  C07C229/00 ,  C07C319/20 ,  A61K31/215 ,  C07C53/10 ,  C07C57/145 ,  C07C59/08 ,  C07C319/14 ,  C07C323/41 ,  C07C323/43 ,  C07C323/52 ,  A01N37/00 ,  A61K31/21

CPC分类号： C07C319/20 ,  A61K31/215 ,  A61P17/00 ,  A61P31/00 ,  C07B2200/07 ,  C07B2200/13 ,  C07C53/10 ,  C07C57/145 ,  C07C59/08 ,  C07C319/14 ,  C07C323/41 ,  C07C323/43 ,  C07C323/52 ,  C07C2601/14 ,  C07C2603/82 ,  Y02P20/55

摘要： Process for the preparation of a compound of formula I in the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIa or in a mixture of a compound of formula IIa with a compound of formula IIb and isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.

摘要翻译： 用于制备结晶形式的单一立体异构体形式的式I化合物的方法，包括使式IIa化合物中的胺基或式IIa化合物与式IIb化合物的混合物脱保护并分离 来自反应混合物的式I化合物; 结晶形式的式I化合物的化合物和盐; 包含这些盐的药物组合物; 在制备式I化合物的方法中制备中间体和中间体的方法。