公开(公告)号：US20240327384A1

公开(公告)日：2024-10-03

申请号：US18580564

申请日：2022-07-21

申请人： Amgen Inc.

发明人： Tian WU ,  Prashant AGARWAL ,  Andreas R. ROTHELI ,  Hyunsoo PARK ,  Michael J. FROHN

IPC分类号： C07D401/14 ,  A61K31/506 ,  C07C15/06 ,  C07C31/02 ,  C07C31/04 ,  C07C31/08 ,  C07C43/04 ,  C07C43/18 ,  C07C49/08 ,  C07C55/02 ,  C07C55/22 ,  C07C69/003 ,  C07C233/05 ,  C07C255/03 ,  C07C275/06 ,  C07C309/04 ,  C07C309/65 ,  C07C309/73 ,  C07D211/90 ,  C07D275/06 ,  C07D307/06 ,  C07D319/12 ,  C07D487/04

CPC分类号： C07D401/14 ,  A61K31/506 ,  C07C15/06 ,  C07C31/02 ,  C07C31/04 ,  C07C31/08 ,  C07C43/046 ,  C07C43/18 ,  C07C49/08 ,  C07C55/02 ,  C07C55/22 ,  C07C69/003 ,  C07C233/05 ,  C07C255/03 ,  C07C275/06 ,  C07C309/04 ,  C07C309/65 ,  C07C309/73 ,  C07D211/90 ,  C07D275/06 ,  C07D307/06 ,  C07D319/12 ,  C07D487/04 ,  C07B2200/13 ,  C07C2601/08

摘要： Disclosed herein is a salt, a crystalline anhydrous form, a hydrate, a solvate, or a co-crystal of a free base compound 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[(2-hydroxyethanesulfonyl)amino]benzamide (Compound A); method of preparation, pharmaceutical compositions, and method of treating a disease mediated by a motor protein kinesin family member 18A (KIF18A) inhibition, wherein said disease is a neoplastic disease, including a cancer or a tumor.

公开(公告)号：US11971337B2

公开(公告)日：2024-04-30

申请号：US17493477

申请日：2021-10-04

申请人： Ventana Medical Systems, Inc.

发明人： James Grille ,  Brian D. Kelly ,  Jerome Kosmeder, II ,  Eric May ,  Noemi Sebastiao ,  Pamela Wirth

IPC分类号： G01N1/30 ,  A61K49/00 ,  C01B15/01 ,  C01B21/08 ,  C07C55/02 ,  C07C55/22 ,  C07C55/24 ,  C12N9/99 ,  G01N33/52

CPC分类号： G01N1/30 ,  C01B15/01 ,  C01B21/08 ,  C07C55/02 ,  C07C55/22 ,  C07C55/24 ,  C12N9/99 ,  G01N33/52 ,  A61K49/001 ,  G01N2001/302 ,  G01N2333/902 ,  G01N2333/908 ,  G01N2333/916

摘要： Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.

公开(公告)号：US20220169913A1

公开(公告)日：2022-06-02

申请号：US17524449

申请日：2021-11-11

申请人： PFP TECHNOLOGY, LLC ,  ASCEND PERFORMANCE MATERIALS OPERATIONS LLC

发明人： Aziz Hikem ,  Madhukar Chetty ,  Derek Vaughn ,  Prasad Taranekar ,  Jeffery W. Balko

IPC分类号： C09K8/575 ,  C09K8/86 ,  C07C19/01 ,  C07C22/04 ,  C07C55/02 ,  C07C55/22 ,  C07C211/09 ,  C07C211/13 ,  C07D303/08 ,  C09K8/60

摘要： Clay stabilization compositions include one or a plurality of triamino compounds and/or derivatives thereof, fluids containing an effective amount of the clay stabilization compositions and methods for making and using same.

公开(公告)号：US20220026319A1

公开(公告)日：2022-01-27

申请号：US17493477

申请日：2021-10-04

申请人： James Grille ,  Brian D. Kelly ,  Jerome Kosmeder, II ,  Eric May ,  Noemi Sebastiao ,  Pamela Wirth

发明人： James Grille ,  Brian D. Kelly ,  Jerome Kosmeder, II ,  Eric May ,  Noemi Sebastiao ,  Pamela Wirth

IPC分类号： G01N1/30 ,  G01N33/52 ,  C07C55/02 ,  C01B21/08 ,  C07C55/22 ,  C07C55/24 ,  C01B15/01

摘要： Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.

公开(公告)号：US20210395186A1

公开(公告)日：2021-12-23

申请号：US17285653

申请日：2019-10-16

申请人： Sandoz AG

发明人： Marijan Stefinovic ,  Dennis Dimo Enkelmann ,  Ulrich Griesser ,  Thomas Gelbrich

IPC分类号： C07C229/36 ,  C07C55/02

摘要： The present invention relates to co-crystals comprising levothyroxine and a dicarboxylic acid, preferably L-tartaric acid or oxalic acid, and processes for the preparation thereof. Furthermore, the invention relates to a pharmaceutical composition comprising a co-crystal of the present invention, preferably the co-crystal comprising levothyroxine and L-tartaric acid or oxalic acid, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment of hypothyroidism.

公开(公告)号：US20190337878A1

公开(公告)日：2019-11-07

申请号：US16389694

申请日：2019-04-19

申请人： KVI LLC

发明人： Alan Thomas Barker ,  Thomas P. Clement

IPC分类号： C07C55/22 ,  C07F9/06 ,  C07C55/02 ,  C07C53/00

摘要： A medical lubricant may comprise a base oil. The medical lubricant can be used on a surgical device.

公开(公告)号：US20190033009A1

公开(公告)日：2019-01-31

申请号：US16023073

申请日：2018-06-29

申请人： Elevance Renewable Sciences, Inc.

发明人： Paul Bertin

IPC分类号： F28D20/02 ,  C09K5/06 ,  C07C31/20 ,  C07C69/67 ,  C07C55/02

摘要： Aliphatic materials and their use in passive heating and cooling applications are generally disclosed. In some embodiments, dibasic acids and esters (diesters) thereof and their use in passive heating and cooling applications are disclosed. In some embodiments, C18 dibasic acids and esters thereof are disclosed, including their use in passive heating and cooling applications. In some embodiments, various olefins, including alkenes and olefinic acids and esters, are disclosed, including their use in passive heating and cooling applications.

公开(公告)号：US10160712B2

公开(公告)日：2018-12-25

申请号：US15548100

申请日：2016-12-07

申请人： CHINA UNIVERSITY OF MINING AND TECHNOLOGY

发明人： Jing Liang ,  Huihui Yang ,  Xianyong Wei ,  Zhimin Zong

IPC分类号： C07C51/21 ,  C07C65/21 ,  C07C55/02 ,  C07C55/14 ,  C07C57/03 ,  C07C59/01 ,  C07C59/08 ,  C07C63/06 ,  C07C63/307 ,  B01J31/04 ,  B01J31/02

摘要： A method of catalytic oxidation of a lignite using oxygen as an oxidant at atmospheric pressure is provided. The method includes the following steps, pulverizing the lignite to 200-mesh or less; drying the pulverized lignite at a temperature of 80° C. in vacuum for 10 h; weighing 0.5 g of the dried lignite and sequentially adding 10 ml of acetic acid, 0.5 mmol of a catalyst and 0.15-0.25 mmol of a cocatalyst into a round-bottom flask filled with the oxygen, keeping oxygen pressure at 0.1 MPa, reacting at a temperature of 80-120° C. for 4-12 h; using oxygen as the oxidant to catalytically oxidize the reacted lignite at an atmospheric pressure of 0.1 MPa; filtering after the reaction is finished; decompressing the filtrate to remove the acetic acid, adding a small amount of ethyl acetate to dissolve, and using an excess CH2N2/ether solution to esterify for 10 h at room temperature; and analyzing the esterified product through a gas chromatography-mass spectrometer.

公开(公告)号：US20180118999A1

公开(公告)日：2018-05-03

申请号：US15800424

申请日：2017-11-01

申请人： PfP TECHNOLOGY, LLC

发明人： Aziz Hikem ,  Madhukar Chetty ,  Derek Vaughn

IPC分类号： C09K8/575 ,  C09K8/60 ,  C07C211/09 ,  C07C211/13 ,  C07C55/02 ,  C07C55/22 ,  C07C22/04 ,  C07C19/01 ,  C07D303/08

CPC分类号： C09K8/575 ,  C07C19/01 ,  C07C22/04 ,  C07C55/02 ,  C07C55/22 ,  C07C211/09 ,  C07C211/13 ,  C07D303/08 ,  C09K8/607 ,  C09K8/86 ,  C09K2208/12

摘要： Clay stabilization compositions include one or a plurality of triamino compounds and/or derivatives thereof, fluids containing an effective amount of the clay stabilization compositions and methods for making and using same.

公开(公告)号：US09670432B2

公开(公告)日：2017-06-06

申请号：US14054148

申请日：2013-10-15

申请人： Saeed Mir Heidari

发明人： Saeed Mir Heidari ,  Atefeh Ebrahimian Kafshae ,  Shahed Abbasi Soha

IPC分类号： C10M169/04 ,  C07C55/02 ,  C10M129/40 ,  C10M129/32 ,  C10M129/34 ,  C10M173/00 ,  C10M129/58

CPC分类号： C10M129/40 ,  C10M129/32 ,  C10M129/34 ,  C10M129/48 ,  C10M129/58 ,  C10M159/02 ,  C10M173/00 ,  C10M2207/122 ,  C10M2207/123 ,  C10M2207/126 ,  C10M2207/16 ,  C10N2210/01 ,  C10N2230/06 ,  C10N2230/16 ,  C10N2230/24 ,  C10N2250/02 ,  C12N1/20

摘要： A method for preventing degradation of physical and chemical properties, and for increasing lubricity, of a hydrocarbon and water emulsion, comprising adding to the emulsion an effective amount of at least one copper salt of a carboxylic acid for enabling at least one bacterium species from Pseudomonas genus to become dominant in the emulsion.