公开(公告)号：US20140179936A1

公开(公告)日：2014-06-26

申请号：US14054063

申请日：2013-10-15

Applicant: AEL MINING SERVICES LIMITED

Inventor： Andre Pienaar ,  Laurence Justin Pienaar Wilson ,  Michael Stockenhuber

IPC: C06B49/00 ,  C07D301/12 ,  C07C201/10 ,  C07C273/18

CPC classification number: C06B49/00 ,  C07C29/36 ,  C07C201/02 ,  C07C201/10 ,  C07C273/18 ,  C07C273/1809 ,  C07C273/1863 ,  C07D301/12 ,  C07C31/24 ,  C07C275/50 ,  C07C275/06 ,  C07C203/04

Abstract: A method producing a surfactant from glycerol by converting glycerol, in a first step, to glycidol, polymerizing glycidol to an aliphatic alcohol and finally substituting a hydroxyl group with a substitute anion.

Abstract translation: 通过将甘油转化成缩水甘油，将缩水甘油聚合成脂肪族醇，最后用取代阴离子取代羟基，从甘油中转化甘油的方法。

公开(公告)号：US20120053342A1

公开(公告)日：2012-03-01

申请号：US13289582

申请日：2011-11-04

Applicant: Hatem Abdallah Belfadhel ,  Hans-Peter Brack ,  Ricardo Godoy-Lopez ,  Dennis James Patrick Maria Willemse

Inventor： Hatem Abdallah Belfadhel ,  Hans-Peter Brack ,  Ricardo Godoy-Lopez ,  Dennis James Patrick Maria Willemse

IPC: C07D265/18 ,  C07C275/28 ,  C07C275/24 ,  C07D263/58 ,  C07D233/34 ,  C07C275/06 ,  C07C271/44 ,  C07D263/22

CPC classification number: C07D233/34 ,  C07C263/04 ,  C07C263/06 ,  C07C269/04 ,  C07C271/58 ,  C07C273/1836 ,  C07D263/22 ,  C07D263/58 ,  C07D265/18 ,  C07C265/08 ,  C07C265/12 ,  C07C271/44 ,  C07C275/06 ,  C07C275/24 ,  C07C275/28

Abstract: The present invention provides methods of forming carbamates, ureas, and isocyanates. In certain embodiments these methods include the step of reacting an amine with an ester-substituted diaryl carbonate to form an activated carbamate which can be further derivatized to form non-activated carbamate or a urea. The urea or carbamate can be subjected to a pyrolysis reaction to form isocyanate.

Abstract translation: 本发明提供了形成氨基甲酸酯，脲和异氰酸酯的方法。 在某些实施方案中，这些方法包括使胺与酯取代的碳酸二芳酯反应以形成活化的氨基甲酸酯的步骤，其可进一步衍生化以形成未活化的氨基甲酸酯或脲。 可以对尿素或氨基甲酸酯进行热解反应以形成异氰酸酯。

公开(公告)号：US20100113819A1

公开(公告)日：2010-05-06

申请号：US12347131

申请日：2008-12-31

Applicant: Hatem Abdallah Belfadhel ,  Hans-Peter Brack ,  Ricardo Godoy-Lopez ,  Dennis James Patrick Maria Willemse

Inventor： Hatem Abdallah Belfadhel ,  Hans-Peter Brack ,  Ricardo Godoy-Lopez ,  Dennis James Patrick Maria Willemse

IPC: C07C263/00 ,  C07C273/00 ,  C07C261/00 ,  C07C269/00 ,  C07C271/40

CPC classification number: C07D233/34 ,  C07C263/04 ,  C07C263/06 ,  C07C269/04 ,  C07C271/58 ,  C07C273/1836 ,  C07D263/22 ,  C07D263/58 ,  C07D265/18 ,  C07C265/08 ,  C07C265/12 ,  C07C271/44 ,  C07C275/06 ,  C07C275/24 ,  C07C275/28

Abstract: The present invention provides methods of forming carbamates, ureas, and isocyanates. In certain embodiments these methods include the step of reacting an amine with an ester-substituted diaryl carbonate to form an activated carbamate which can be further derivitized to form non-activated carbamate or a urea. The urea or carbamate can be subjected to a pyrolysis reaction to form isocyanate.

Abstract translation: 本发明提供了形成氨基甲酸酯，脲和异氰酸酯的方法。 在某些实施方案中，这些方法包括使胺与酯取代的二芳基碳酸酯反应以形成活化的氨基甲酸酯的步骤，其可被进一步衍生以形成未活化的氨基甲酸酯或脲。 可以对尿素或氨基甲酸酯进行热解反应以形成异氰酸酯。

公开(公告)号：US07276613B1

公开(公告)日：2007-10-02

申请号：US10110862

申请日：2000-10-18

Applicant: Alexandros Makriyannis ,  Qian Liu ,  Andreas Goutopoulos

Inventor： Alexandros Makriyannis ,  Qian Liu ,  Andreas Goutopoulos

IPC: C07C231/00 ,  C07C233/00 ,  C07D265/30

CPC classification number: C07C233/05 ,  C07C233/65 ,  C07C235/06 ,  C07C271/12 ,  C07C275/06

Abstract: Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy, as well as suppression of the immune system, enhancement of appetite and in treatment of certain mental disorders.

Abstract translation: 提出了对大麻素CB1和/或CB2受体位点具有高亲和力的新型复方壬酰胺。 此外，大多数类似物表现出比花生四烯酰乙酰胺更高的代谢稳定性。 改善的受体亲和力和选择性和/或更高的代谢稳定性使得这些类似物在个体和动物中用作治疗疼痛，青光眼，癫痫，与化学疗法相关的恶心以及抑制免疫系统，增加食欲和 治疗某些精神障碍。

公开(公告)号：US07053244B2

公开(公告)日：2006-05-30

申请号：US10520402

申请日：2003-07-03

Applicant: Jochem Henkelmann ,  Theodor Weber ,  Thorsten Rohde ,  Ralph Busch

Inventor： Jochem Henkelmann ,  Theodor Weber ,  Thorsten Rohde ,  Ralph Busch

IPC: C07C273/18

CPC classification number: C07C273/1809 ,  C07C275/06

Abstract: The invention relates to a process for the preparation of tetrasubstituted ureas by reaction of the corresponding amines with phosgene in the presence of an aqueous inorganic base at a temperature in the range from 0 to 150° C., which comprises: feeding the corresponding amine, the phosgene and the aqueous inorganic base on average continuously to the reaction apparatus, forming a two-phase system in the reaction apparatus through the choice of the tetrasubstituted ureas to be prepared, through the mixing ratios of the substances and substance mixtures to be fed in, through the temperature during the reaction and, where appropriate, through the feed of an organic solvent which is not completely miscible with water, and discharging the reaction mixture on average continuously from the reaction apparatus.

Abstract translation: 本发明涉及通过在无机碱水溶液存在下，在0至150℃的温度范围内使相应的胺与光气反应来制备四取代的脲的方法，该方法包括：将相应的胺， 光气和水无机碱平均连续向反应装置中，通过选择要制备的四取代脲形成反应装置中的两相体系，通过待进料的物质和物质混合物的混合比例 通过反应期间的温度，并且在适当的情况下，通过进料与水不完全混溶的有机溶剂，并从反应装置中连续排出反应混合物。

公开(公告)号：US20040204599A1

公开(公告)日：2004-10-14

申请号：US10485103

申请日：2004-02-02

Inventor： Zhenhua Yang

IPC: C07C053/02

CPC classification number: C07D239/36 ,  C07C31/20 ,  C07C43/13 ,  C07C43/2055 ,  C07C49/185 ,  C07C49/258 ,  C07C53/126 ,  C07C53/19 ,  C07C57/03 ,  C07C59/01 ,  C07C59/185 ,  C07C59/52 ,  C07C69/30 ,  C07C69/84 ,  C07C69/92 ,  C07C211/52 ,  C07C229/08 ,  C07C243/14 ,  C07C251/08 ,  C07C251/38 ,  C07C275/06 ,  C07C275/68 ,  C07C309/08 ,  C07C311/16 ,  C07C323/52 ,  C07D233/32 ,  C07D233/70 ,  C07D239/42 ,  C07D239/54 ,  C07D473/30 ,  C07D473/34

Abstract: Compounds containing a specific saturated or unsaturated branched chain terminal group; a polar leading group; and a long-chain aliphatic, non-cyclic, saturated or unsaturated, substituted or unsubstituted, hydrocarbon group linking them; and having anti-cancer, immunosuppression alleviation, immune boosting and anti-inflammation activity.

Abstract translation: 含有特定饱和或不饱和支链端基的化合物; 极地领导小组; 和长链脂族，非环状，饱和或不饱和的取代或未取代的连接它们的烃基; 并具有抗癌，免疫抑制减轻，免疫增强和抗炎活性。

公开(公告)号：US20030186967A1

公开(公告)日：2003-10-02

申请号：US10068711

申请日：2002-02-06

Applicant: American Home Products Corporation

Inventor： Kenneth Lewis Kees ,  Lloyd M. Garrick ,  Ariamala Gopalsamy

IPC: A61K031/55 ,  A61K031/505 ,  A61K031/4168 ,  A61K031/24

CPC classification number: C07D239/42 ,  A61K31/24 ,  A61K31/4168 ,  A61K31/505 ,  A61K31/55 ,  C07C275/06 ,  C07C275/24 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C279/08 ,  C07D213/56 ,  C07D223/12 ,  C07D233/48 ,  C07D239/14 ,  C07D307/68 ,  C07D405/12

Abstract: Compounds of the formula 1 wherein R1, R2, R3, R4, R5 and n are as defined in the specification are useful in the treatment of various disorders including, but not limited to, cancer, angiogenesis, restenosis, inflammation, bone diseases, and as antiviral agents.

Abstract translation: 下式的化合物其中R 1，R 2，R 3，R 4，R 5和n如本说明书中所定义，可用于治疗各种疾病，包括但不限于 癌症，血管生成，再狭窄，炎症，骨骼疾病和抗病毒剂。

公开(公告)号：US4136164A

公开(公告)日：1979-01-23

申请号：US802371

申请日：1977-06-02

Applicant: David G. Rowsell ,  Roger Hems

Inventor： David G. Rowsell ,  Roger Hems

IPC: A61K8/02 ,  A61K8/42 ,  A61Q11/00 ,  A61Q19/00 ,  C07C275/06 ,  C07C275/26 ,  C07D207/06 ,  C07D295/215 ,  A61K7/22

CPC classification number: A61Q19/00 ,  A61K8/0208 ,  A61K8/42 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/005 ,  C07C275/06 ,  C07C275/26 ,  C07D207/06 ,  C07D295/215 ,  A61K2800/244 ,  A61Q1/06 ,  A61Q1/12 ,  A61Q13/00 ,  A61Q19/002 ,  A61Q19/10 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q9/02 ,  C07C2101/14

Abstract: Cyclic and acyclic amides, substituted ureas and sulphonamides are disclosed having the property of stimulating the cold receptors of the nervous system of the body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.

Abstract translation: 公开了环状和非环状酰胺，取代的脲和磺酰胺，其具有刺激身体的神经系统的冷受体以产生冷感的性质，并且用于各种可食用和局部制剂的目的。

公开(公告)号：US3597443A

公开(公告)日：1971-08-03

申请号：US3597443D

申请日：1968-04-08

Applicant: PROCTOR CHEMICAL CO INC

Inventor： CROWTHER MILTON

IPC: C07C273/18 ,  C07C275/06 ,  C07D233/34 ,  C07D233/70 ,  C07D49/34

CPC classification number: C07D233/34 ,  C07C273/1863 ,  C07C275/06

Abstract: ETHYLENE UREA SUBSTANTIALLY FREE OF WATER-INSOLUBLE BYPRODUCTS SUCH AS OCCUR IN CONVENTIONAL COMMERCIAL ETHYLENE UREA IS MADE BY ADDING ABOUT 1 TO 10% FORMALDEHYDE OR AN EQUIVALENT ALDEHYDE DONOR TO THE REACTION MASS OF UREA AND ETHYLENE DIAMINE AS THE MASS COOLS DOWN FROM MAXIMUM REACTION TEMPERATURE AROUND 270* C. AND BEFORE IT REACHES 200* C. THE PRODUCT IS USEFUL IN FORMING FORMALDEHYDE ADDUCTS USED IN CREASE-PROOFING OF TEXTILES.

公开(公告)号：US3297753A

公开(公告)日：1967-01-10

申请号：US46862465

申请日：1965-06-30

Applicant: ATLAS CHEM IND

Inventor： RUTLEDGE THOMAS F

IPC: C07C273/18 ,  C07C275/06

CPC classification number: C07C273/189 ,  C07C275/06