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公开(公告)号：US11740555B2
公开(公告)日：2023-08-29
申请号：US17175957
申请日：2021-02-15
发明人： Yukako Anryu , Satoshi Yamaguchi , Koji Ichikawa
IPC分类号： G03F7/004 , G03F7/38 , C08F220/18 , C07C69/84 , C07D309/12 , G03F7/038 , G03F7/039
CPC分类号： G03F7/0046 , C07C69/84 , C07D309/12 , C08F220/1808 , G03F7/0045 , G03F7/038 , G03F7/039 , G03F7/38
摘要： Disclosed is a resist composition including a compound represented by formula (I), a resin having an acid-labile group and an acid generator, the resin having an acid-labile group including at least one selected from the group consisting of a structural unit represented by formula (a1-1) and a structural unit represented by formula (a1-2):
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2.发明申请公开(公告)号：US20190192474A1
公开(公告)日：2019-06-27
申请号：US16292906
申请日：2019-03-05
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/255 , A61K31/095 , C07C69/017 , A61K31/235 , C07C309/42 , C07C65/19 , A61K45/06 , A61K31/222 , A61K31/216 , A61K31/192 , A61K31/185 , A61K31/10 , C07C65/03 , C07C57/44 , C07C309/75 , C07C309/24 , C07C309/68 , A61K31/225 , C07C59/68 , C07C69/84 , A61K9/00
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
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公开(公告)号：US20190023644A1
公开(公告)日：2019-01-24
申请号：US16065889
申请日：2016-06-03
发明人： Durgadas BOLIKAL , Joachim B. KOHN
IPC分类号： C07C69/732 , C08G64/10 , C07C69/734 , C07C233/51 , C07C69/84 , C08G64/38 , C08G64/06 , A61L31/18 , A61L31/14 , A61L31/16 , A61L31/06
CPC分类号： C07C69/732 , A61L31/06 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/604 , C07C69/36 , C07C69/40 , C07C69/734 , C07C69/736 , C07C69/84 , C07C233/47 , C07C233/51 , C08G64/06 , C08G64/10 , C08G64/12 , C08G64/38 , C08L69/00
摘要： Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
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公开(公告)号：US20180028484A1
公开(公告)日：2018-02-01
申请号：US15455844
申请日：2017-03-10
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/255 , A61K31/185 , A61K31/235 , C07C309/42 , C07C65/19 , A61K9/00 , C07C69/84 , C07C59/68 , A61K31/225 , C07C309/68 , C07C309/24 , C07C309/75 , C07C57/44 , C07C65/03 , A61K31/10 , A61K45/06 , A61K31/222 , A61K31/216 , A61K31/192 , A61K31/095 , C07C69/017
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
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5.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of rosacea 有权使用2,5-二羟基苯化合物和衍生物治疗酒渣鼻公开(公告)号：US09592216B2
公开(公告)日：2017-03-14
申请号：US14603784
申请日：2015-01-23
发明人： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/255 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K45/06 , A61K31/225 , C07C59/68 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K31/235 , C07C57/44 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , A61K31/10
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药用于治疗和/或预防酒渣肠炎的用途。
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6.发明授权Compounds and compositions for use a modulators of tau aggregation and alleviation of tauopathies 有权用于tau聚集和减轻tau蛋白病的调节剂的化合物和组合物公开(公告)号：US09469605B2
公开(公告)日：2016-10-18
申请号：US14300572
申请日：2014-06-10
申请人： PROTAMED, INC.
发明人： Alan D Snow , Qubai Hu , Thomas Lake , Judy Cam
IPC分类号： C07C235/56 , C07C275/34 , A61K31/167 , A61K31/17 , C07C311/29 , C07C235/38 , C07C237/22 , A61K31/05 , A61K31/164 , A61K31/18 , A61K31/415 , A61K31/4196 , C07D249/08 , C07C307/10 , C07D235/00 , C07C69/84 , C07C237/40
CPC分类号： C07C311/29 , A61K31/05 , A61K31/164 , A61K31/167 , A61K31/18 , A61K31/415 , A61K31/4196 , C07C69/84 , C07C235/38 , C07C235/64 , C07C235/76 , C07C237/22 , C07C237/40 , C07C275/34 , C07C307/10 , C07D235/00 , C07D249/08
摘要： This invention relates to the use of bis- and tris-dihydroxyaryl compounds as well as sulfonamides, heteroaryls, tricycloalkyl and their analogs and pharmaceutically acceptable salts, for modulating tau aggregation and alleviating tauopathies, such as Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and familial frontotemporal dementia/Parkinsonism linked to chromosome 17 (FTDP-17), amyotrophic lateral sclerosis/Parkinsonism-dementia complex, argyrophilic grain dementia, dementia pugilistic, diffuse neurofibrillary tangles with calcification, progressive subcortical gliosis and tangle only dementia.
摘要翻译： 本发明涉及双 - 和三 - 二羟基芳基化合物以及磺酰胺，杂芳基，三环烷基及其类似物和药学上可接受的盐用于调节tau聚集和减轻tau蛋白病如阿尔茨海默病（AD），皮克病（PiD） ），进行性核核麻痹（PSP），皮质基底变性（CBD）和与17号染色体（FTDP-17）相关的家族性额颞叶痴呆/帕金森综合征，肌萎缩性侧索硬化/帕金森综合征 - 痴呆综合征，嗜酸性粒细胞性痴呆，痴呆性痴呆，弥漫性神经原纤维缠结 钙化，进行性皮质下胶质增生，仅缠结痴呆。
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7.发明申请METHODS FOR DETECTING AND DETERMINING LEVELS OF MONOLIGNOL ESTER CONJUGATES INCORPORATED INTO LIGNIN AND COMPOUNDS RELATING THERETO 审中-公开用于检测和测定与其相关的葡萄糖和化合物的单烯醇酯共聚物的水平的方法公开(公告)号：US20160187345A1
公开(公告)日：2016-06-30
申请号：US14985720
申请日：2015-12-31
发明人： John Ralph , Steven D Karlen , Fachuang Lu , Dharshana Padmakshan
CPC分类号： C07C69/73 , C07B2200/05 , C07C69/007 , C07C69/16 , C07C69/732 , C07C69/734 , C07C69/84 , C07C69/86 , C07C69/92 , G01N33/50 , G01N2400/26 , G01N2458/15 , G01N2560/00
摘要： Described is a method of detecting and/or determining levels of incorporation of monolignol ferulate conjugate esters into lignin by derivatizing the lignin, reductively cleaving the lignin, labeling the cleavage products, and then detecting cleavage products derived from monolignol ester conjugates via differential attachment of the label.
摘要翻译： 描述了通过衍生木质素，还原性切割木质素，标记裂解产物，然后通过差异附着来检测衍生自单螺环酯酯缀合物的裂解产物，来检测和/或确定单胺阿魏酸酯偶联物酯掺入木质素中的水平的方法 标签。
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公开(公告)号：US20140194604A1
公开(公告)日：2014-07-10
申请号：US14149924
申请日：2014-01-08
IPC分类号： C07D209/48 , C07C45/28 , C07C67/29 , C07C245/24 , C07C303/30
CPC分类号： C07D209/48 , C07B41/06 , C07C45/28 , C07C51/373 , C07C67/29 , C07C67/313 , C07C201/12 , C07C231/12 , C07C247/04 , C07C303/30 , C07C303/40 , C07C2601/14 , C07C49/255 , C07C49/175 , C07C49/173 , C07C235/74 , C07C311/16 , C07C205/57 , C07C309/73 , C07C49/403 , C07C49/04 , C07C49/84 , C07C49/784 , C07C69/14 , C07C69/84 , C07C69/78 , C07C59/76 , C07C69/716
摘要： The present invention is directed to methods for oxidizing internal olefins to ketones. In various embodiments, each method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of (a) a biscationic palladium salt; and (b) an oxidizing agent; dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one C2-6 carbon nitrile and optionally at least one secondary alkyl amide, said method conducted under conditions sufficient to convert at least 50 mol % of the initial internal olefin to a ketone, said ketone positioned on a carbon of the initial internal olefin. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed oil derivatives and a bioactive natural product are described.
摘要翻译： 本发明涉及将内烯烃氧化成酮的方法。 在各种实施方案中，每种方法包括使具有初始内烯烃的有机基质与（a）双阳离子钯盐的混合物接触; 和（b）氧化剂; 溶解或分散在溶剂体系中以形成反应混合物，所述溶剂体系包含至少一种C 2-6碳腈和任选的至少一种仲烷基酰胺，所述方法在足以将至少50mol％的初始 内部烯烃与酮反应，所述酮位于初始内烯烃的碳上。 转化在室温下发生，显示出宽的底物范围。 描述了种子油衍生物和生物活性天然产物的氧化应用。
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9.发明授权Phenol compounds and positive photosensitive resin composition including the same 有权苯酚化合物和包含其的正型感光性树脂组合物公开(公告)号：US08697320B2
公开(公告)日：2014-04-15
申请号：US13242120
申请日：2011-09-23
申请人： Ji-Young Jeong , Min-Kook Chung , Hyun-Yong Cho , Yong-Sik Yoo , Jeong-Woo Lee , Jong-Hwa Lee , Hwan-Sung Cheon , Soo-Young Kim , Young-Ho Kim , Jae-Hyun Kim , Su-Min Park
发明人： Ji-Young Jeong , Min-Kook Chung , Hyun-Yong Cho , Yong-Sik Yoo , Jeong-Woo Lee , Jong-Hwa Lee , Hwan-Sung Cheon , Soo-Young Kim , Young-Ho Kim , Jae-Hyun Kim , Su-Min Park
CPC分类号： G03F7/0226 , C07C69/84 , G03F7/0233
摘要： Disclosed are a novel phenol compound comprising a compound represented by Chemical Formula 1, a compound represented by Chemical Formula 2, or a combination thereof, and a positive photosensitive resin composition including the same.
摘要翻译： 公开了包含由化学式1表示的化合物，由化学式2表示的化合物或其组合的新型酚化合物和包含其的正性感光性树脂组合物。
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10.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer 有权使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US08101660B2
公开(公告)日：2012-01-24
申请号：US11839522
申请日：2007-08-15
申请人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
发明人： Pedro Cuevas Sánchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Morgan , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC分类号： A61K31/222 , A61K31/12 , A61K31/10
CPC分类号： A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
摘要： The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
摘要翻译： 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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