公开(公告)号：US10480016B2

公开(公告)日：2019-11-19

申请号：US14435714

申请日：2013-10-15

Applicant: Calysta, Inc.

Inventor： Joshua A. Silverman ,  Drew D. Regitsky

IPC: C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12P7/04 ,  C12P7/16 ,  C12P17/02

Abstract: The present disclosure relates to genetically engineered microorganisms for biological oxidation of hydrocarbons, including production of alcohols from alkanes or epoxides from alkenes, and related methods and systems.

公开(公告)号：US10337043B2

公开(公告)日：2019-07-02

申请号：US15111733

申请日：2015-01-16

Applicant: CALYSTA, INC.

Inventor： Joshua A. Silverman ,  Lorraine Joan Giver ,  Jana Mueller ,  Renee M. Saville ,  Drew D. Regitsky

IPC: C12P19/18 ,  A23K10/12 ,  A23K50/00 ,  C12N9/00 ,  A23K20/163 ,  C12N9/10 ,  C12P19/04

Abstract: The present disclosure relates to recombinant microorganisms engineered for enhanced production of a desired carbohydrate, as well as related biomass, and compositions which are useful, inter alia, as animal feed ingredients. The present disclosure also provides related methods.

公开(公告)号：US10011840B2

公开(公告)日：2018-07-03

申请号：US15833890

申请日：2017-12-06

Applicant: CALYSTA, INC.

Inventor： Joshua A. Silverman ,  Effendi Leonard ,  Renee M. Saville

IPC: C12N15/52 ,  C12N1/20 ,  C12N9/12 ,  C12N9/00 ,  C12N9/04

CPC classification number: C12N15/52 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/93 ,  C12Y101/01008 ,  C12Y101/01027 ,  C12Y207/0103 ,  C12Y602/01001

Abstract: The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate (e.g., glycerol) as a primary or sole carbon source and methods for growing methanotrophic bacteria on the multi-carbon substrate.

公开(公告)号：US20170362562A1

公开(公告)日：2017-12-21

申请号：US15625858

申请日：2017-06-16

Applicant: Calysta, Inc.

Inventor： Luan Thanh NGUYEN ,  Arild Johannessen ,  Graham Ian Aylen ,  Joshua A. Silverman

IPC: C12M1/00 ,  C12M1/42 ,  C12M1/34 ,  C12N1/30

Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.

公开(公告)号：US09845474B2

公开(公告)日：2017-12-19

申请号：US14438537

申请日：2013-10-24

Applicant: Calysta, Inc.

Inventor： Joshua A. Silverman ,  Effendi Leonard ,  Renee M. Saville

IPC: C12N15/52 ,  C12N1/20 ,  C12N9/00 ,  C12N9/12 ,  C12N9/04

CPC classification number: C12N15/52 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/93 ,  C12Y101/01008 ,  C12Y101/01027 ,  C12Y207/0103 ,  C12Y602/01001

Abstract: The present disclosure relates to genetically engineered methanotrophic bacteria with the capability of growing on a multi-carbon substrate as a primary or sole carbon source and methods for growing methanotrophic bacteria on a multi-carbon substrate.

公开(公告)号：US20160333307A1

公开(公告)日：2016-11-17

申请号：US15111723

申请日：2015-01-16

Applicant: CALYSTA, INC.

Inventor： Howard Lam Ho Fong ,  John H Grate ,  Luan Nguyen ,  Joshua A. Silverman ,  Lisa Marie Newman ,  Lorraine Joan Giver ,  Drew D. Regitsky

IPC: C12N1/20 ,  A23N17/00 ,  C12R1/01 ,  C10L1/08 ,  C10G3/00 ,  C10L1/04 ,  C10L1/06 ,  A23K10/10 ,  C12N15/74

CPC classification number: C12N1/20 ,  A23K10/10 ,  A23N17/00 ,  B01D53/85 ,  B01D2251/95 ,  B01D2256/24 ,  B01D2256/245 ,  B01D2257/304 ,  B01D2258/05 ,  C10G3/00 ,  C10G2300/1025 ,  C10G2300/202 ,  C10G2400/02 ,  C10G2400/04 ,  C10G2400/08 ,  C10L1/04 ,  C10L1/06 ,  C10L1/08 ,  C10L3/102 ,  C10L2290/544 ,  C12N9/0051 ,  C12N9/0069 ,  C12N15/74 ,  C12P7/6463 ,  C12R1/01 ,  Y02A50/2359 ,  Y02P30/20

Abstract: The present disclosure provides compositions and methods for using recombinant C1 metabolizing microorganisms capable of metabolizing sulfur containing compounds and other contaminants to biologically convert sour or acidic natural gas into high-value molecules, and to allow recovery of stranded oil.

Abstract translation: 本公开提供使用能够代谢含硫化合物和其它污染物的重组C1代谢微生物的组合物和方法，以将酸性或酸性天然气生物转化为高价值分子，并允许回收绞股油。

公开(公告)号：US09410168B2

公开(公告)日：2016-08-09

申请号：US14813804

申请日：2015-07-30

Applicant: Calysta, Inc.

Inventor： Joshua A. Silverman ,  Sol M. Resnick ,  Michael Mendez ,  Renee M. Saville ,  Sungwon Lee ,  Luan Nguyen

IPC: C12P7/64 ,  C12N15/74 ,  C12P5/00 ,  C10L1/02 ,  C10L1/04 ,  C10G3/00 ,  C12N9/16 ,  C12N9/00 ,  C12N1/16 ,  C12N1/20 ,  C12N9/10 ,  C10G47/00

CPC classification number: C12P7/6409 ,  C10G3/00 ,  C10G3/50 ,  C10G47/00 ,  C10G2300/1014 ,  C10L1/02 ,  C10L1/04 ,  C10L2200/0469 ,  C10L2270/02 ,  C10L2270/04 ,  C10L2290/26 ,  C12N1/16 ,  C12N1/20 ,  C12N9/1029 ,  C12N9/16 ,  C12N9/93 ,  C12N15/52 ,  C12N15/74 ,  C12P5/00 ,  C12P7/6463 ,  C12P7/649 ,  C12R1/01 ,  C12Y203/01039 ,  C12Y301/02 ,  C12Y602/01003 ,  C12Y604/01002 ,  Y02E50/13 ,  Y02E50/343 ,  Y02P20/52 ,  Y02P30/20

Abstract: The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C1 metabolizing microorganism reactor system for converting C1 substrates, such as methane or methanol, into biomass and subsequently into biofuels, bioplastics, or the like.

Abstract translation: 本公开涉及用于生产生物燃料的生物工程方法，特别是使用C1代谢微生物反应器系统来将C1底物如甲烷或甲醇转化为生物质，随后转化为生物燃料，生物塑料等。

公开(公告)号：US12234445B2

公开(公告)日：2025-02-25

申请号：US17293832

申请日：2019-12-26

Applicant: Calysta, Inc.

Inventor： Renee M. Saville ,  Joshua A. Silverman ,  Vincent Tang ,  Eric G. Luning ,  Paloma Rueda ,  Megan Hsi ,  Yelena Stegantseva

IPC: C12N1/32 ,  C12N1/30 ,  C12N9/10 ,  C12N9/12 ,  C12N9/90 ,  C12P13/04 ,  C12P21/00

Abstract: The present disclosure provides methanotrophic bacteria that are modified to produce less glycogen, and methods of using the modified methanotrophic bacteria to produce a desired product, such as protein(s) or metabolite(s).

公开(公告)号：US12116563B2

公开(公告)日：2024-10-15

申请号：US17732263

申请日：2022-04-28

Applicant: Calysta, Inc.

Inventor： Luan Thanh Nguyen ,  Arild Johannessen ,  Graham Ian Aylen ,  Joshua A. Silverman

IPC: C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12N1/30

CPC classification number: C12M45/04 ,  C12M21/00 ,  C12M29/00 ,  C12M29/18 ,  C12M29/20 ,  C12M35/08 ,  C12M41/40 ,  C12N1/30 ,  C12M21/02

Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.

公开(公告)号：US11572539B2

公开(公告)日：2023-02-07

申请号：US17199981

申请日：2021-03-12

Applicant: Calysta, Inc.

Inventor： Luan Thanh Nguyen ,  Joshua A. Silverman ,  Graham Ian Aylen

IPC: B01D19/00 ,  C12M1/00 ,  C12M1/107 ,  C12M1/12

Abstract: Reactors, systems and processes for the production of biomass by culturing microorganisms in aqueous liquid culture medium circulating inner loop reactor which utilize nonvertical pressure reduction zones are described. Recovery and processing of the culture microorganisms to obtain products, such as proteins or hydrocarbons is described.