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公开(公告)号：US09637467B2
公开(公告)日：2017-05-02
申请号：US14846016
申请日：2015-09-04
Applicant: Allergan, Inc.
Inventor： Yariv Donde , Jeremiah H. Nguyen , Karen M. Kedzie , Daniel W. Gil , John E. Donello , Wha-Bin Im
IPC: C07D333/56 , A61K31/557 , A61K31/5575 , C07D333/62 , C07D409/08 , A61K31/559 , C07C59/90 , C07C69/732 , C07C57/26 , C07C57/48 , C07C69/738
CPC classification number: C07D333/56 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C57/26 , C07C57/48 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/62 , C07D409/08
Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
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2.发明申请公开(公告)号：US20150353582A1
公开(公告)日：2015-12-10
申请号：US14759063
申请日：2014-01-31
Applicant: PROMERUS, LLC
Inventor： ANDREW BELL , KEITARO SETO , STEPHEN WESTCOTT , ROBERT G POTTER
IPC: C07F5/02
CPC classification number: C07F5/027 , C07C17/093 , C07C17/361 , C07C29/03 , C07C41/03 , C07C51/15 , C07C303/28 , C07C2602/42 , C07C33/14 , C07C43/1786 , C07C57/26 , C07C309/66 , C07C22/02
Abstract: Embodiments of norbornenylhydrocarbylene dihydrocarbylboranes represented by the Formula (I), and methods of forming such norbornenylhydrocarbylene dihydrocarbylboranes are provided, where its is 0, 1 or 2, A is a C2 to C12 hydrocarbylene group; R1 and R2 are independently selected from a substituted or unsubstituted C1 to C12 hydrocarbyl, substituted or unsubstituted, monocyclic or bicyclic C5 to C7 rings, and R1 and R2, taken together with the boron atom to which they are attached, can form a monocyclic or bicyclic ring; wherein the norbornenylhydrocarbylene dihydrocarbylboranes of Formula (I) are subject to the proviso that 9-norbornenylethyl-9-borabicyclo[3.3.1]nonane is not included.
Abstract translation: 提供由式（I）表示的降冰片烯基亚烃基二烃基硼烷的实例，以及形成这样的降冰片烯基亚烃基二烃基硼烷的方法，其中其为0,1或2，A为C 2至C 12亚烃基; R 1和R 2独立地选自取代或未取代的C 1至C 12烃基，取代或未取代的单环或双环C 5至C 7环，并且R 1和R 2与它们所连接的硼原子一起可以形成单环或 双环; 其中式（I）的降冰片烯基亚烃基二烃基硼烷的条件是不包括9-降冰片烯乙基-9-硼双环[3.3.1]壬烷。
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公开(公告)号：US09156810B2
公开(公告)日：2015-10-13
申请号：US14268264
申请日：2014-05-02
Applicant: ALLERGAN, INC.
Inventor： Yariv Donde , Jeremiah H. Nguyen , Karen M. Kedzie , Daniel W. Gil , John E. Donello , Wha-Bin Im
IPC: C07D333/62 , A61K31/557 , A61K31/5575 , C07D333/56 , C07D409/08 , A61K31/559 , C07C59/90 , C07C69/732
CPC classification number: C07D333/56 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C57/26 , C07C57/48 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/62 , C07D409/08
Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
Abstract translation: 本文公开了一种方法，其包括向患有炎性肠病的哺乳动物施用化合物用于治疗所述疾病，所述化合物具有式I的结构，其中X，Y，B，R2，R3，R4，R5，R6 并且n具有本文找到的含义。
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公开(公告)号：US09056826B2
公开(公告)日：2015-06-16
申请号：US14130921
申请日：2012-06-28
Applicant: Anthony A. Birkbeck
Inventor： Anthony A. Birkbeck
IPC: C07C57/26 , C07C67/297 , C07C69/007 , C07C69/24 , C07C67/00 , C07C67/283 , C07C69/145 , C07C69/63 , C07C45/51 , C07C45/74 , C07C29/09
CPC classification number: C07C57/26 , C07C29/095 , C07C45/511 , C07C45/74 , C07C67/00 , C07C67/283 , C07C67/297 , C07C69/007 , C07C69/145 , C07C69/24 , C07C69/63 , C07C2602/42 , C07C69/78 , C07C47/225 , C07C33/14
Abstract: The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, and wherein R represents a C2-C10 group of formula CORa wherein Ra is an alkyl or alkenyl group optionally comprising one or two ether functional groups or is a phenyl or benzyl group optionally substituted by one to three alkyl, alkoxyl, carboxyl, acyl, amino or nitro groups or halogen atoms. The invention concerns also the use of compound (I) for the synthesis of β-santalol or of derivatives thereof.
Abstract translation: 本发明涉及制备其立体异构体或其混合物中任何一种形式的式（I）化合物的方法，其中R表示式CORa的C 2 -C 10基团，其中R a为烷基或链烯基 任选地包含一个或两个醚官能团，或者是任选被一至三个烷基，烷氧基，羧基，酰基，氨基或硝基或卤素原子取代的苯基或苄基。 本发明还涉及化合物（I）用于合成檀香醇或其衍生物的用途。
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公开(公告)号：US20150057351A1
公开(公告)日：2015-02-26
申请号：US14464232
申请日：2014-08-20
Applicant: SUCAMPO AG
Inventor： Ryuji UENO
IPC: C07C57/26 , C07C53/134
CPC classification number: C07C57/26 , A61K31/352 , C07C53/134
Abstract: A method for treating neuropathic pain in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative, is provided.
Abstract translation: 提供一种治疗哺乳动物受试者神经性疼痛的方法，其包括施用有效量的脂肪酸衍生物。
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Patent Agency Ranking
公开(公告)号：US08754122B2
公开(公告)日：2014-06-17
申请号：US12945013
申请日：2010-11-12
Applicant: Yariv Donde , Jeremiah H. Nguyen , Karen M. Kedzie , Daniel W. Gil , John E. Donello , Wha-Bin Im
Inventor： Yariv Donde , Jeremiah H. Nguyen , Karen M. Kedzie , Daniel W. Gil , John E. Donello , Wha-Bin Im
IPC: A61K31/557 , A61K31/5575 , A61K31/559
CPC classification number: C07D333/56 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C57/26 , C07C57/48 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/62 , C07D409/08
Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
Abstract translation: 本文公开了一种方法，其包括向患有炎性肠病的哺乳动物施用化合物用于治疗所述疾病，所述化合物具有式I的结构，其中X，Y，B，R2，R3，R4，R5，R6 并且n具有本文找到的含义。
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公开(公告)号：US20130344527A1
公开(公告)日：2013-12-26
申请号：US13868444
申请日：2013-04-23
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Nicholas J. Agard , Jennifer A. Prescher , Jeremy Michael Baskin , Ellen May Sletten
CPC classification number: A61K31/655 , C07C45/292 , C07C45/511 , C07C45/63 , C07C49/457 , C07C49/753 , C07C57/26 , C07C59/72 , C07C63/66 , C07C63/74 , C07C69/708 , C07C69/76 , C07C2601/18 , C07D207/416 , C07D207/452 , C07D249/16 , C07D495/04 , G01N33/531 , G01N33/6803 , G01N33/6842 , C07C49/573
Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
Abstract translation: 本发明提供改性环炔化合物; 以及这些化合物在修饰生物分子中的使用方法。 本发明的特征在于可以在生理条件下进行的环加成反应。 通常，本发明涉及使改性的环炔与靶生物分子上的叠氮化物部分反应，产生共价修饰的生物分子。 反应的选择性及其与水性环境的相容性使其在体内（例如，在细胞表面或细胞内）和体外（例如，肽和其它聚合物的合成，生物修饰（例如，标记的）氨基酸 ）。
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公开(公告)号：US20120022283A1
公开(公告)日：2012-01-26
申请号：US13138227
申请日：2010-01-22
Applicant: Johann Mulzer , Jürgen Ramharter , Steffen Hering , Sophia Khom
Inventor： Johann Mulzer , Jürgen Ramharter , Steffen Hering , Sophia Khom
IPC: C07C57/26 , C07C69/732
CPC classification number: C07C69/608 , A61K31/16 , C07C29/42 , C07C57/26 , C07C69/732 , C07C231/02 , C07C233/02 , C07C233/10 , C07C233/16 , C07C243/32 , C07C2602/24 , C07D307/93
Abstract: The present invention is directed to compounds, intermediates and methods for making valerenic acid and its derivatives as well as the use of such compounds as GABAA receptor ligands.
Abstract translation: 本发明涉及制备戊酰酸及其衍生物的化合物，中间体和方法以及这些化合物如GABA A受体配体的用途。
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公开(公告)号：US20110230669A1
公开(公告)日：2011-09-22
申请号：US12879241
申请日：2010-09-10
Applicant: VOLKER KRAFT , GERHARD KRETZSCHMAR , KAI ROSSEN
Inventor： VOLKER KRAFT , GERHARD KRETZSCHMAR , KAI ROSSEN
IPC: C07D493/18 , C07C51/36 , C07C67/303
CPC classification number: C07C51/36 , C07B2200/07 , C07C67/303 , C07C2602/28 , C07D493/18 , C07D493/20 , C07C57/26 , C07C69/608
Abstract: This application relates to a process for the production of (2R)-dihydroartemisinic acid or (2R)-dihydroartemisinic acid esters from artemisinic acid or artemisinic acid esters, respectively, by diimine hydrogenation of the exocyclic CC-double bond, and use of said process in the production of the antimalarial drug artemisinin.
Abstract translation: 本申请涉及分别通过外环CC-双键的二亚胺氢化从青蒿酸或青蒿酸酯制备（2R） - 二氢青蒿酸或（2R） - 二氢青蒿酸酯的方法，以及使用所述方法 在抗疟药物青蒿素的生产中。
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公开(公告)号：US20110172435A1
公开(公告)日：2011-07-14
申请号：US12945013
申请日：2010-11-12
Applicant: Yariv Donde , Jeremiah H. Nguyen , Karen M. Kedzie , Daniel W. Gil , John E. Donello , Wha-Bin Im
Inventor： Yariv Donde , Jeremiah H. Nguyen , Karen M. Kedzie , Daniel W. Gil , John E. Donello , Wha-Bin Im
IPC: C07D257/04 , C07D333/52 , C07C69/738 , C07C59/90
CPC classification number: C07D333/56 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C57/26 , C07C57/48 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/62 , C07D409/08
Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
Abstract translation: 本文公开了一种方法，其包括向患有炎性肠病的哺乳动物施用化合物用于治疗所述疾病，所述化合物具有式I的结构，其中X，Y，B，R2，R3，R4，R5，R6 并且n具有本文找到的含义。
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