公开(公告)号：US09988328B2

公开(公告)日：2018-06-05

申请号：US15520876

申请日：2015-10-22

申请人： DAIKIN INDUSTRIES, LTD.

发明人： Yuusuke Etou ,  Shingo Nakamura

IPC分类号： C07C19/08 ,  C07C43/12 ,  B01J27/12 ,  B01J21/04 ,  B01J23/26 ,  B01J23/06 ,  B01J21/06

CPC分类号： C07C19/08 ,  B01J21/04 ,  B01J21/063 ,  B01J23/06 ,  B01J23/26 ,  B01J27/12 ,  B01J35/1042 ,  C07C17/361 ,  C07C43/12

摘要： An object of the present invention is to extend the catalyst lifetime in a method for producing fluoromethane by pyrolyzing fluorine-containing methyl ether in the presence of a catalyst. The present invention provides a method for producing fluoromethane by pyrolyzing a fluorine-containing methyl ether represented by Formula (1) in a gas phase in the presence of a catalyst, the pyrolysis being conducted at a moisture concentration of 100 ppm or less, wherein R1 and R2 are identical or different, and each represents a substituted or unsubstituted straight or branched monovalent aliphatic hydrocarbon group, substituted or unsubstituted monovalent aromatic hydrocarbon group, substituted or unsubstituted monovalent cyclic aliphatic hydrocarbon group, hydrogen atom, or halogen atom.

公开(公告)号：US20180127447A1

公开(公告)日：2018-05-10

申请号：US15816816

申请日：2017-11-17

申请人： Trustees of Boston College ,  Massachusetts Institute of Technology

发明人： Amir H. Hoveyda ,  Hanmo Zhang ,  Ming Joo Koh ,  Richard Royce Schrock

IPC分类号： C07F11/00 ,  C07C17/361 ,  C07C17/266 ,  C07D333/54 ,  C07D209/10 ,  C07D209/48 ,  C07F5/02 ,  C07F7/18 ,  C07J9/00 ,  C07J51/00 ,  C07C17/10 ,  C07C41/30 ,  C07C67/333 ,  C07C67/307 ,  B01J31/22 ,  C07B37/04 ,  C07C17/14 ,  C07C17/278 ,  C07C17/275 ,  C07C17/269 ,  C07C17/02 ,  C07C21/19 ,  C07C21/14 ,  C07C21/04 ,  C07C25/24 ,  C07C21/18 ,  C07C22/04 ,  C07C22/08 ,  C07C25/28 ,  C07C43/225 ,  C07C43/192 ,  C07C43/17 ,  C07C69/65 ,  C07C69/63 ,  C07C69/753

CPC分类号： C07F11/00 ,  B01J31/2265 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07B37/04 ,  C07C17/02 ,  C07C17/10 ,  C07C17/14 ,  C07C17/266 ,  C07C17/269 ,  C07C17/275 ,  C07C17/278 ,  C07C17/361 ,  C07C21/14 ,  C07C21/18 ,  C07C22/08 ,  C07C37/62 ,  C07C41/30 ,  C07C45/63 ,  C07C67/307 ,  C07C67/333 ,  C07C69/753 ,  C07C2601/14 ,  C07C2603/26 ,  C07D209/10 ,  C07D209/48 ,  C07D333/54 ,  C07F5/025 ,  C07F7/1804 ,  C07J9/00 ,  C07J51/00 ,  C07C21/19 ,  C07C21/04 ,  C07C25/24 ,  C07C22/04 ,  C07C22/00 ,  C07C22/02 ,  C07C25/28 ,  C07C43/225 ,  C07C43/192 ,  C07C43/17 ,  C07C69/65 ,  C07C69/63

摘要： The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.

公开(公告)号：US09895454B2

公开(公告)日：2018-02-20

申请号：US15323046

申请日：2015-07-02

申请人： The Regents of the University of California

发明人： Maxim Sergeev ,  Federica Morgia ,  Robert Michael Van Dam ,  Mark Lazari

IPC分类号： A61K51/04 ,  C07B59/00 ,  C07D207/09 ,  C07C17/361 ,  C07H19/052 ,  C07D207/16 ,  C07D405/06 ,  C07C67/333 ,  C07C201/12 ,  C07C253/30 ,  C07D217/22 ,  C07D241/16 ,  C07D213/61 ,  B01J21/06

CPC分类号： A61K51/04 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0491 ,  B01J21/063 ,  C07B59/00 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C17/361 ,  C07C67/307 ,  C07C67/333 ,  C07C201/12 ,  C07C253/30 ,  C07C2601/14 ,  C07D207/09 ,  C07D207/16 ,  C07D213/61 ,  C07D215/18 ,  C07D217/22 ,  C07D241/16 ,  C07D405/04 ,  C07D405/06 ,  C07H19/052 ,  C07C69/76 ,  C07C205/12 ,  C07C255/50 ,  C07C25/13 ,  C07C22/08 ,  C07C25/22 ,  C07C19/08 ,  C07C23/10

摘要： Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.

公开(公告)号：US20180002257A1

公开(公告)日：2018-01-04

申请号：US15546724

申请日：2016-02-05

申请人： DAIKIN INDUSTRIES, LTD.

发明人： Shingo NAKAMURA ,  Yuusuke ETOU ,  Keisuke TANO ,  Yoshinori TANAKA

IPC分类号： C07C17/361 ,  C07C17/38 ,  F25J3/02

CPC分类号： C07C17/361 ,  C07C17/38 ,  C07C17/383 ,  F25J3/0219 ,  F25J2230/30 ,  F25J2290/12 ,  C07C19/08

摘要： A method for producing methyl fluoride, comprising the steps of: (1) pyrolyzing a starting compound in a gas phase to thereby obtain a mixed gas containing methyl fluoride and acid fluoride; and (2) rectifying the mixed gas obtained in step (1) to thereby obtain methyl fluoride.

公开(公告)号：US20170305820A1

公开(公告)日：2017-10-26

申请号：US15516124

申请日：2015-09-30

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： Tilman C. Zipplies ,  Klaus Hintzer ,  Monika A. Willert-Porada ,  Thorsten Gerdes ,  Jens Herdegen ,  Achim Schmidt-Rodenkirchen ,  Stephan Aschauer

IPC分类号： C07C17/361 ,  B01J19/12

CPC分类号： C07C17/361 ,  B01J19/088 ,  B01J19/126 ,  B01J2219/0875 ,  B01J2219/0896 ,  B01J2219/1206 ,  B01J2219/1293 ,  C07C17/23 ,  C07C21/185 ,  C07C21/18

摘要： Provided is a process for producing fluorinated alkenes by providing a microwave plasma in a reactor chamber, introducing a protective gas feed into the reactor chamber, and contacting a conversion feed comprising at least one fluorinated linear or branched alkane with the plasma. Also provided are an apparatus and the use of the process and the apparatus.

公开(公告)号：US20170291865A1

公开(公告)日：2017-10-12

申请号：US15512446

申请日：2015-09-18

申请人： UNIMATEC CO., LTD.

发明人： Takeshi FUKUSHIMA

IPC分类号： C07C21/18 ,  C07C69/63 ,  C07C67/293 ,  C07C17/363

CPC分类号： C07C21/18 ,  C07C17/361 ,  C07C17/363 ,  C07C67/293 ,  C07C69/14 ,  C07C69/63

摘要： A polyfluoroalkyl allyl compound represented by the general formula: CF3(CF2)n(CH2CF2)a(CF2CF2)bCH2CH═CH2  [I] (n: 0 to 5, a: 1 or 2, b: 0 to 3). The polyfluoroalkyl allyl compound is produced by reacting a carboxylic acid allyl adduct represented by the general formula: CF3(CF2)n(CH2CF2)a(CF2CF2)bCH2CHICH2OCOR′  [II] (n, a, and b are as defined above, and R′: a C1-C3 alkyl group) with a transition metal. This method for producing provides a polyfluoroalkyl allyl compound used as a synthetic intermediate for a fluorine-containing alkylsilane compound that can remove free iodine derived from the raw material compound, before a hydrosilylation reaction is performed, without using a metal reagent having a high environmental impact, and that has excellent handling properties.

公开(公告)号：US09738578B2

公开(公告)日：2017-08-22

申请号：US15116088

申请日：2015-02-09

申请人： ZEON CORPORATION

发明人： Tatsuya Sugimoto

IPC分类号： C07C17/361 ,  B01J31/14

CPC分类号： C07C17/361 ,  B01J31/146 ,  B01J2231/42 ,  C07C17/093 ,  C07C19/08

摘要： The present invention is a method for producing a fluorohydrocarbon represented by a structural formula (3) comprising bringing a secondary or tertiary ether compound represented by a structural formula (1) into contact with an acid fluoride represented by a structural formula (2) in a hydrocarbon-based solvent in the presence of a boron trifluoride complex. (In structural formulae (1) to (3), each of R1 and R2 represents an alkyl group having 1 to 3 carbon atoms, R3 represents a hydrogen atom, a methyl group, or an ethyl group, and each of R4 and R5 represents a methyl group or an ethyl group, provided that R1 and R2 are optionally bonded to each other to form a ring structure.)

公开(公告)号：US09624147B2

公开(公告)日：2017-04-18

申请号：US14922237

申请日：2015-10-26

申请人： THE CHEMOURS COMPANY FC LLC

发明人： Stephen James Getty ,  George Murray Volker ,  Pelin Hacarlioglu

IPC分类号： C07C17/361 ,  C07C19/16

CPC分类号： C07C17/361 ,  C07C19/16

摘要： An improved process for producing perfluoroalkyl iodides of formula (I) F(CF2CF2)n—I  (I) wherein n is an integer from 2 to 3, wherein the improvement comprises thermolyzing at least one perfluoroalkyl iodide of formula (II), optionally in the presence of perfluoroethyl iodide, formula (III) F(CF2CF2)m—I  (II) F(CF2CF2)p—I  (III) wherein m is an integer greater than or equal to 4, and p is 1, wherein a) the molar ratio of formula (III) to formula (II) is less than 1.0, b) the residence time is from about 0.1 to about 10 seconds, and c) the temperature is from about 450° C. to about 500° C.

公开(公告)号：US20160332877A1

公开(公告)日：2016-11-17

申请号：US15026349

申请日：2014-10-02

申请人： DAIKIN INDUSTRIES, LTD. ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： Shoji HARA ,  Yosuke KISHIKAWA ,  Atsushi SHIRAI ,  Takashi NAMIKAWA ,  Sumi ISHIHARA

IPC分类号： C01B7/24 ,  C07C67/333 ,  C07C67/307 ,  C07C231/12 ,  C07C45/67 ,  C07C45/63 ,  C07C41/22 ,  C07C319/20 ,  C07C209/74 ,  C07C17/361 ,  C07D309/10 ,  C07C17/354 ,  C07D493/04 ,  C07D209/10 ,  C01D3/02

CPC分类号： C01B7/24 ,  C01D3/02 ,  C01D13/00 ,  C07C17/354 ,  C07C17/361 ,  C07C41/22 ,  C07C45/63 ,  C07C45/673 ,  C07C67/307 ,  C07C67/333 ,  C07C209/74 ,  C07C231/12 ,  C07C319/20 ,  C07C2603/86 ,  C07D209/10 ,  C07D309/10 ,  C07D493/04

摘要： An object of the present invention is to provide a novel substance that has a high reactivity as a fluorinating agent, is effectively used in various fluorination reactions, and is safely handled even in air. As the solution for achieving this object, the present invention provides a complex obtained by reacting bromine trifluoride with at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals in a nonpolar solvent. This complex serves as a fluorinating agent that provides excellent fluorination performance and that is stable in air.

摘要翻译： 本发明的目的是提供作为氟化剂具有高反应性的新物质，有效地用于各种氟化反应中，并且即使在空气中也被安全地处理。 作为用于实现该目的的方案，本发明提供了一种通过在非极性溶剂中使三氟化硼与至少一种选自卤代金属和卤代氢金属的金属卤化物反应而获得的络合物。 该复合物用作提供优异的氟化性能并且在空气中稳定的氟化剂。

公开(公告)号：US09381508B2

公开(公告)日：2016-07-05

申请号：US14834420

申请日：2015-08-24

申请人： AbbVie Inc.

发明人： Shashank Shekhar ,  Thaddeus S. Franczyk ,  David M. Barnes ,  Travis B. Dunn ,  Anthony R. Haight ,  Vincent S. Chan

IPC分类号： B01J31/18 ,  B01J31/24 ,  C07C1/30 ,  C07C1/32 ,  C07C17/093 ,  C07C201/10 ,  C07C253/14 ,  C07C253/30 ,  C07C273/18 ,  C07C303/36 ,  C07C303/40 ,  C07C319/14 ,  C07C41/01 ,  C07C45/68 ,  C07C45/71 ,  C07D209/12 ,  C07D209/34 ,  C07D209/42 ,  C07D213/76 ,  C07D239/54 ,  C07D265/30 ,  C07D295/033 ,  C07F1/02 ,  C07F5/02 ,  C07F9/40 ,  C07F9/50 ,  C07F9/6568

CPC分类号： B01J31/2423 ,  B01J31/189 ,  B01J31/2419 ,  B01J31/2438 ,  B01J31/2466 ,  B01J31/2485 ,  B01J31/249 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4277 ,  B01J2231/4283 ,  B01J2231/4288 ,  B01J2231/4294 ,  B01J2231/44 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/0288 ,  B01J2531/824 ,  B01J2540/10 ,  B01J2540/40 ,  C07C1/26 ,  C07C1/30 ,  C07C1/321 ,  C07C17/093 ,  C07C17/2635 ,  C07C17/361 ,  C07C41/01 ,  C07C41/30 ,  C07C45/61 ,  C07C45/68 ,  C07C45/71 ,  C07C201/10 ,  C07C253/14 ,  C07C253/30 ,  C07C273/1854 ,  C07C273/1863 ,  C07C303/36 ,  C07C303/40 ,  C07C319/14 ,  C07C2531/24 ,  C07C2531/26 ,  C07D209/12 ,  C07D209/34 ,  C07D209/42 ,  C07D213/76 ,  C07D239/54 ,  C07D265/30 ,  C07D295/033 ,  C07F1/02 ,  C07F5/025 ,  C07F5/04 ,  C07F9/4021 ,  C07F9/4841 ,  C07F9/505 ,  C07F9/5072 ,  C07F9/509 ,  C07F9/572 ,  C07F9/65031 ,  C07F9/65583 ,  C07F9/65683 ,  C07F9/657163 ,  Y02P20/52 ,  C07C275/28 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C255/10 ,  C07C321/30 ,  C07C205/45 ,  C07C15/06 ,  C07C49/784

摘要： The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.