公开(公告)号：US20230100818A1

公开(公告)日：2023-03-30

申请号：US17785821

申请日：2020-12-18

Applicant: NICHIAS CORPORATION ,  KYOTO INSTITUTE OF TECHNOLOGY

Inventor： Tomoya SHIMIZU ,  Ayumi TOH ,  Tsutomu KONNO

IPC: C08K5/06 ,  C07C35/50 ,  C07C43/196 ,  C07C43/192 ,  C08L27/12 ,  C08K5/053

Abstract: The present invention provides a crosslinking agent which can improve crosslinked fluoroelastomer high-temperature vapor resistance and a crosslinked fluoroelastomer having improved high-temperature vapor resistance. The present invention provides a compound having a structure represented by the following formula (1) (in the formula, R1 to R6 are each a hydrogen atom, a substituent, or a leaving group, and two or more of R1 to R6 are leaving groups; Ra to Rc are each a hydrogen atom or a substituent; and n is an integer from 2 to 5).

公开(公告)号：US10857247B2

公开(公告)日：2020-12-08

申请号：US16555290

申请日：2019-08-29

Applicant: The General Hospital Corporation

Inventor： David R. Elmaleh ,  Timothy M. Shoup ,  Hongning Fu

IPC: A61K51/04 ,  C07D471/10 ,  C07H13/10 ,  C07H15/26 ,  C07C43/253 ,  C07H13/02 ,  C07C43/192 ,  C07C43/196

Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

公开(公告)号：US20180127447A1

公开(公告)日：2018-05-10

申请号：US15816816

申请日：2017-11-17

Applicant: Trustees of Boston College ,  Massachusetts Institute of Technology

Inventor： Amir H. Hoveyda ,  Hanmo Zhang ,  Ming Joo Koh ,  Richard Royce Schrock

IPC: C07F11/00 ,  C07C17/361 ,  C07C17/266 ,  C07D333/54 ,  C07D209/10 ,  C07D209/48 ,  C07F5/02 ,  C07F7/18 ,  C07J9/00 ,  C07J51/00 ,  C07C17/10 ,  C07C41/30 ,  C07C67/333 ,  C07C67/307 ,  B01J31/22 ,  C07B37/04 ,  C07C17/14 ,  C07C17/278 ,  C07C17/275 ,  C07C17/269 ,  C07C17/02 ,  C07C21/19 ,  C07C21/14 ,  C07C21/04 ,  C07C25/24 ,  C07C21/18 ,  C07C22/04 ,  C07C22/08 ,  C07C25/28 ,  C07C43/225 ,  C07C43/192 ,  C07C43/17 ,  C07C69/65 ,  C07C69/63 ,  C07C69/753

CPC classification number: C07F11/00 ,  B01J31/2265 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07B37/04 ,  C07C17/02 ,  C07C17/10 ,  C07C17/14 ,  C07C17/266 ,  C07C17/269 ,  C07C17/275 ,  C07C17/278 ,  C07C17/361 ,  C07C21/14 ,  C07C21/18 ,  C07C22/08 ,  C07C37/62 ,  C07C41/30 ,  C07C45/63 ,  C07C67/307 ,  C07C67/333 ,  C07C69/753 ,  C07C2601/14 ,  C07C2603/26 ,  C07D209/10 ,  C07D209/48 ,  C07D333/54 ,  C07F5/025 ,  C07F7/1804 ,  C07J9/00 ,  C07J51/00 ,  C07C21/19 ,  C07C21/04 ,  C07C25/24 ,  C07C22/04 ,  C07C22/00 ,  C07C22/02 ,  C07C25/28 ,  C07C43/225 ,  C07C43/192 ,  C07C43/17 ,  C07C69/65 ,  C07C69/63

Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.

公开(公告)号：US20170240809A1

公开(公告)日：2017-08-24

申请号：US15439680

申请日：2017-02-22

Applicant: JNC CORPORATION ,  JNC PETROCHEMICAL CORPORATION

Inventor： Yasuyuki GOTOH ,  Takahiro KUBO

IPC: C09K19/34 ,  C07C43/225 ,  C07C25/18 ,  C07C43/192 ,  C07C69/753 ,  C07C69/78 ,  C09K19/30 ,  C07C23/18

CPC classification number: C09K19/3402 ,  C07C13/28 ,  C07C22/04 ,  C07C23/18 ,  C07C25/18 ,  C07C43/192 ,  C07C43/225 ,  C07C69/75 ,  C07C69/753 ,  C07C69/76 ,  C07C69/78 ,  C07C69/92 ,  C07C2101/14 ,  C07C2601/12 ,  C07C2601/14 ,  C09K19/3001 ,  C09K19/3003 ,  C09K19/3066 ,  C09K19/3068 ,  C09K19/32 ,  C09K2019/0466 ,  C09K2019/122 ,  C09K2019/123 ,  C09K2019/3004 ,  C09K2019/3009 ,  C09K2019/301 ,  C09K2019/3016 ,  C09K2019/3019 ,  C09K2019/3022 ,  C09K2019/3077 ,  C09K2019/308 ,  C09K2019/3083 ,  C09K2019/3422 ,  C09K2019/3425

Abstract: The invention provides a liquid crystal compound satisfying at least one of physical properties such as a high stability to heat or light, a high clearing point (or a high maximum temperature), a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a small dielectric anisotropy, a suitable elastic constant and a good compatibility with other liquid crystal compounds, a liquid crystal composition including this compound, and a liquid crystal display device containing this composition. The invention provdes a compound represented by formula (1): where R1 and R2 is alkyl having 1 to 20 carbons or the like; one of L1 and L2 is both hydrogens, and the other is both fluorines; Z1 and Z2 are independently a single bond, —COO—, —OCO—, —OCH2—, —CH2O—, —CF2O—, —OCF2—, —CH2CH2—, —CH═CH—, —C≡C— or the like.

公开(公告)号：US09481618B2

公开(公告)日：2016-11-01

申请号：US14003512

申请日：2012-03-09

Applicant: Kenichiro Itami ,  Yasutomo Segawa ,  Akiko Yagi

Inventor： Kenichiro Itami ,  Yasutomo Segawa ,  Akiko Yagi

IPC: C07C15/20 ,  C07C1/28 ,  C07C41/30 ,  C07C43/188 ,  C07C1/22 ,  C07C2/64 ,  C07C39/12 ,  C07C43/20 ,  C07C35/52 ,  C07C43/192

CPC classification number: C07C15/20 ,  C07C1/22 ,  C07C1/28 ,  C07C2/64 ,  C07C35/52 ,  C07C39/12 ,  C07C41/30 ,  C07C43/188 ,  C07C43/192 ,  C07C43/20 ,  C07C2601/16 ,  C07C2602/10 ,  C07C2603/90 ,  C07C13/64

Abstract: A cyclopolyarylene compound represented by Formula (1): wherein k is the same or different, and each represents 0, 1 or 2; m is the same or different, and each represents 1, 2 or 3; and n represents 3, 4, 5 or 6.

公开(公告)号：US20080051596A1

公开(公告)日：2008-02-28

申请号：US11906973

申请日：2007-10-04

Applicant: Terry Balko ,  John Daeuble ,  Paul Schmitzer ,  Carla Yerkes ,  Thomas Siddall

Inventor： Terry Balko ,  John Daeuble ,  Paul Schmitzer ,  Carla Yerkes ,  Thomas Siddall

IPC: C07C25/24 ,  C07C211/45 ,  C07C255/50 ,  C07C33/46 ,  C07C381/00 ,  C07C43/192 ,  C07C47/14

CPC classification number: C07D213/79 ,  A01N43/40 ,  C07C25/13 ,  C07C39/26 ,  C07C39/27 ,  C07C43/225 ,  C07C47/55 ,  C07C47/575 ,  C07C49/80 ,  C07C211/52 ,  C07C217/84 ,  C07C233/25 ,  C07C233/65 ,  C07C255/50 ,  C07C255/54 ,  C07C323/09 ,  C07F1/02 ,  C07F1/08 ,  C07F3/00 ,  C07F3/02 ,  C07F5/025 ,  C07F7/2208 ,  A01N25/32

Abstract: 4-Aminopicolinic acids having tri- and tetra-substituted aryl substituents in the 6-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

公开(公告)号：US07270856B2

公开(公告)日：2007-09-18

申请号：US10537026

申请日：2003-11-05

Applicant: Andreas Taugerbeck ,  Michael Heckmeier ,  Peer Kirsch ,  Georg Luessem ,  Eike Poetsch

Inventor： Andreas Taugerbeck ,  Michael Heckmeier ,  Peer Kirsch ,  Georg Luessem ,  Eike Poetsch

IPC: C09K19/30 ,  C09K19/34 ,  C09K19/32 ,  C07D319/06 ,  C07D309/02 ,  C07C43/192 ,  C07C25/13

CPC classification number: C09K19/3402 ,  C09K19/32 ,  C09K2019/327 ,  C09K2019/3422 ,  Y10T428/10

Abstract: The invention relates to novel cyclobutane derivatives of the formula (I), in which R1, R2, A, Z, m, n and o have the meaning indicated in claim 1, to the use thereof as components of liquid-crystalline media, and to liquid-crystal and electro-optical display elements which contain the liquid-crystalline media according to the invention

Abstract translation: 本发明涉及式（I）的新型环丁烷衍生物，其中R 1，R 2，A，Z，m，n和o具有以下含义： 权利要求1，其作为液晶介质的组分的用途，以及含有根据本发明的液晶介质的液晶和电光显示元件

公开(公告)号：US6051522A

公开(公告)日：2000-04-18

申请号：US464459

申请日：1995-06-05

Applicant: Jurgen Rohrmann ,  Frank Kuber

Inventor： Jurgen Rohrmann ,  Frank Kuber

IPC: C07B61/00 ,  C07C1/207 ,  C07C1/24 ,  C07C13/465 ,  C07C13/547 ,  C07C13/66 ,  C07C17/00 ,  C07C17/361 ,  C07C22/08 ,  C07C23/34 ,  C07C25/22 ,  C07C41/30 ,  C07C43/188 ,  C07C43/192 ,  C07C43/20 ,  C07C43/215 ,  C07C43/225 ,  C07C45/46 ,  C07C45/67 ,  C07C49/665 ,  C07C49/67 ,  C07C49/675 ,  C07F7/08 ,  C07F9/00 ,  C07F17/00 ,  C07F19/00 ,  C08F4/42 ,  C08F4/602 ,  C08F4/639 ,  C08F4/6392 ,  C08F4/64 ,  C08F4/655 ,  C08F4/659 ,  C08F4/76 ,  C08F10/00 ,  C08F110/06 ,  B01J31/00 ,  B01J37/00 ,  C08F4/02 ,  C08F4/60

CPC classification number: C08F10/00 ,  C07C13/465 ,  C07C13/547 ,  C07C45/46 ,  C07C45/67 ,  C07C49/665 ,  C07C49/67 ,  C07C49/675 ,  C07F17/00 ,  C07F7/0809 ,  C07C2102/08 ,  C07C2103/20 ,  C08F110/06 ,  C08F4/63912 ,  C08F4/63927 ,  C08F4/65912 ,  Y10S526/943

Abstract: A catalyst containing the combination which comprises:(a) an aluminoxane, a compound of the formula R.sub.x NH.sub.4-x, BR'.sub.4, R.sub.x PH.sub.4-x, BR'.sub.4, R.sub.3 CBR'.sub.4 or BR'.sub.3, or a mixture thereof wherein X is an integer from 1 to 4 and the radicals R are identical or different and are a C.sub.1 -C.sub.10 -alkyl or a C.sub.6 -C.sub.18 -aryl or 2 radicals R together with the atom joining them form a ring, and the radicals R' are identical or different and are a C.sub.6 -C.sub.18 -aryl which optionally are substituted by alkyl, haloalkyl or fluorine, and(b) a metallocene of the formula VI ##STR1## in which M.sup.1 is titanium, zirconium, hafnium, vanadium, niobium or tantalum,R.sup.1 is (C.sub.3 -C.sub.20)alkyl, (C.sub.6 -C.sub.14)aryl, (C.sub.4 -C.sub.10)alkoxy, (C.sub.2 -C.sub.10)alkenyl, (C.sub.7 -C.sub.20)arylalkyl, (C.sub.7 -C.sub.20)alkylaryl, (C.sub.6 -C.sub.10)aryloxy, (C.sub.1 -C.sub.10)fluoroalkyl, (C.sub.6 -C.sub.10)halogenoaryl, (C.sub.2 -C.sub.10)alkynyl; a radical --SiR.sup.6.sub.3, in which R.sup.6 is (C.sub.1 -C.sub.10)alkyl; a halogen atom; or an aromatic radical having 5 or 6 ring members in the ring, at lease one of which is a heteroatom,R.sup.2, R.sup.3 and R.sup.4 are identical or different and are hydrogen; (C.sub.1 -C.sub.20)alkyl, (C.sub.6 -C.sub.14)aryl, (C.sub.1 -C.sub.10)alkoxy, (C.sub.2 -C.sub.10)alkenyl, (C.sub.7 -C.sub.20)arylalkyl, (C.sub.7 -C.sub.20)alkylaryl, (C.sub.6 -C.sub.10)aryloxy, (C.sub.1 -C.sub.10)fluoroalkyl, (C.sub.6 -C.sub.10)halogenoaryl, (C.sub.2 -C.sub.10)alkynyl; a radical --SiR.sup.6.sub.3, in which R.sup.6 is (C.sub.1 -C.sub.10)alkyl, a halogen atom, or a heteroaromatic radical which has 5 or 6 ring members and can contain one or more heteroatoms, or adjacent radicals R.sup.1 -R.sup.4 ; with the atoms joining them, form one or more rings,R.sup.5 is hydrogen,R.sup.7 is a radical ##STR2## in which M.sup.2 is carbon, silicon, germanium or tin.

Abstract translation: 含有该组合的催化剂包括：（a）铝氧烷，式RxNH4-x，BR'4，RxPH4-x，BR'4，R3CBR'4或BR'3的化合物或其混合物，其中X为 1〜4的整数，基团R相同或不同，为C1-C10-烷基或C6-C18-芳基或2个基团R与连接的原子一起形成环，基团R'相同 或不同的并且是任选被烷基，卤代烷基或氟取代的C 6 -C 18 - 芳基，和（b）式VI的茂金属，其中M 1是钛，锆，铪，钒，铌或钽，R 1是（ （C 1 -C 10）烷基，（C 6 -C 10）芳基，（C 1 -C 10）芳氧基，（C 1 -C 10） -C 10）氟代烷基，（C 6 -C 10）卤代芳基，（C 2 -C 10）炔基; 基团-SiR 63，其中R 6是（C 1 -C 10）烷基; 卤素原子; 或在环中具有5或6个环成员的芳族基团，其中至少一个为杂原子，R 2，R 3和R 4相同或不同，为氢; （C 1 -C 10）烷基，（C 6 -C 10）芳基，（C 1 -C 10）芳氧基，（C 1 -C 10） C1-C10）氟烷基，（C6-C10）卤代芳基，（C2-C10）炔基; 基团-SiR 63，其中R 6是（C 1 -C 10）烷基，卤素原子或具有5或6个环成员并且可以含有一个或多个杂原子或相邻基团R 1 -R 4的杂芳族基团; 原子连接它们，形成一个或多个环，R 5是氢，R 7是其中M 2是碳，硅，锗或锡的基团。

公开(公告)号：US5969074A

公开(公告)日：1999-10-19

申请号：US64575

申请日：1993-05-21

Applicant: William Brown Farnham ,  Mario Joseph Nappa

Inventor： William Brown Farnham ,  Mario Joseph Nappa

IPC: C07C43/13 ,  C07C43/17 ,  C07C43/192 ,  C07C43/247 ,  C07D323/00 ,  C07F7/18 ,  C08F20/14 ,  C08F214/18 ,  C08G65/00 ,  C08G65/336 ,  C08G65/34 ,  C08G67/00 ,  C07D317/16 ,  C07D321/00 ,  C07D319/12

CPC classification number: C07C43/17 ,  C07C43/137 ,  C07C43/192 ,  C07C43/247 ,  C07D323/00 ,  C07F7/1852 ,  C08F20/14 ,  C08F214/186 ,  C08G65/007 ,  C08G65/336 ,  C08G65/34 ,  C07C2101/04 ,  C07C2101/06

Abstract: A reaction of perfluoroolefins with bis(silyl) ethers to produce novel partially fluorinated and perfluorinated copolymers and macrocyclic compounds is disclosed.

Abstract translation: 公开了全氟烯烃与双（甲硅烷基）醚的反应以产生新的部分氟化和全氟化的共聚物和大环化合物。

公开(公告)号：US5929264A

公开(公告)日：1999-07-27

申请号：US890942

申请日：1997-07-10

Applicant: Jurgen Rohrmann ,  Frank Kuber

Inventor： Jurgen Rohrmann ,  Frank Kuber

IPC: C07B61/00 ,  C07C1/207 ,  C07C1/24 ,  C07C13/465 ,  C07C13/547 ,  C07C13/66 ,  C07C17/00 ,  C07C17/361 ,  C07C22/08 ,  C07C23/34 ,  C07C25/22 ,  C07C41/30 ,  C07C43/188 ,  C07C43/192 ,  C07C43/20 ,  C07C43/215 ,  C07C43/225 ,  C07C45/46 ,  C07C45/67 ,  C07C49/665 ,  C07C49/67 ,  C07C49/675 ,  C07F7/08 ,  C07F9/00 ,  C07F17/00 ,  C07F19/00 ,  C08F4/42 ,  C08F4/602 ,  C08F4/639 ,  C08F4/6392 ,  C08F4/64 ,  C08F4/655 ,  C08F4/659 ,  C08F4/76 ,  C08F10/00 ,  C08F110/06 ,  C07F7/28 ,  C07F11/00

CPC classification number: C08F10/00 ,  C07C13/465 ,  C07C13/547 ,  C07C45/46 ,  C07C45/67 ,  C07C49/665 ,  C07C49/67 ,  C07C49/675 ,  C07F17/00 ,  C07F7/0809 ,  C07C2102/08 ,  C07C2103/20 ,  C08F110/06 ,  C08F4/63912 ,  C08F4/63927 ,  C08F4/65912 ,  Y10S526/943

Abstract: The invention relates to a process for the preparation of a compound of the formula IV or IVa ##STR1## in which R.sup.1 -R.sup.5 are preferably hydrogen or alkyl, which comprises reacting a compound I ##STR2## with a compound II ##STR3## in which X.sup.1 and X.sup.2 are preferably halogen, to give the corresponding indanones, which are converted into the compounds IV and IVa by reduction and dehydration. The compounds IV and IVa are important intermediate products for the preparation of chiral metallocene complexes which are suitable catalyst components for olefin polymerization.

Abstract translation: 本发明涉及制备式IV或IVa化合物的方法，其中R 1 -R 5优选为氢或烷基，其包括使化合物I与其中X 1和X 2优选为卤素的化合物II反应，得到 相应的茚满酮，通过还原和脱水转化成化合物IV和IVa。 化合物IV和IVa是制备用于烯烃聚合的合适的催化剂组分的手性茂金属络合物的重要中间产物。