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公开(公告)号：US20190177256A1
公开(公告)日：2019-06-13
申请号：US16324159
申请日：2017-08-07
Applicant: Bayer CropScience Aktiengesellschaft
Inventor： Daniel GALLENKAMP , Mark James FORD
IPC: C07C37/00
CPC classification number: C07C37/002 , A01N31/08 , C07C33/28 , C07C37/00 , C07C37/001 , C07C37/06 , C07C39/20 , C07C39/373 , C07C309/66 , C07C309/73 , C07C39/27 , C07C39/28
Abstract: The present invention relates to a method for preparing substituted styrene derivatives.
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公开(公告)号：US09193659B2
公开(公告)日：2015-11-24
申请号：US12918001
申请日：2009-02-16
Applicant: Giovanni Battista Giovenzana , Camilla Cavallotti , Luciano Lattuada , Fulvio Uggeri
Inventor： Giovanni Battista Giovenzana , Camilla Cavallotti , Luciano Lattuada , Fulvio Uggeri
IPC: C07C221/00 , C07C51/363 , C07B39/00 , C07C37/62 , C07C67/307 , C07C231/12 , C07C237/46 , C25B3/06
CPC classification number: C07C51/363 , C07B39/00 , C07C37/62 , C07C67/307 , C07C231/12 , C07C237/46 , C25B3/06 , C07C65/03 , C07C69/88 , C07C235/48 , C07C39/27
Abstract: The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).
Abstract translation: 本发明涉及一种制备碘化酚的方法，特别涉及一种方法，其包括将式（1）的3,5-二取代的酚电化学碘化为相应的3,5-二取代的-2， 式（2）的4,6-三碘苯酚，其是用于合成x射线造影剂的有用的中间体，以及造影剂本身的制备。 此外，本发明包括将式（6）的3,5-二取代的苯胺电化学碘化为相应的式（7）的3,5-二取代-2,4,6-三碘苯胺。
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公开(公告)号：US20150148430A1
公开(公告)日：2015-05-28
申请号：US14551306
申请日：2014-11-24
Applicant: Tansna Therapeutics Inc.
Inventor： Max Baker , Rajesh Kumar Mishra , John J. Talley , Eduardo J. Martinez
CPC classification number: C07C43/23 , A61K31/05 , A61K31/255 , A61K31/4365 , A61K31/661 , A61K31/7004 , C07C39/06 , C07C39/07 , C07C39/17 , C07C39/24 , C07C39/26 , C07C39/27 , C07C39/28 , C07C39/42 , C07C2601/02 , C07C2601/08
Abstract: The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, & R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
Abstract translation: 本公开提供了可用于治疗具有式（I）的结构的神经系统疾病如惊厥和震颤的酚类化合物：其中R2，R4和R5如详细描述中所定义; 包含至少一种化合物的药物组合物; 和治疗神经病症的方法。
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公开(公告)号：US08648223B2
公开(公告)日：2014-02-11
申请号：US13753628
申请日：2013-01-30
Inventor： Junichi Yoshida , Seiji Suga , Kazuhide Kataoka , Koji Midorikawa , Yuji Hagiwara
IPC: C07C22/00
CPC classification number: C07C17/02 , C07B39/00 , C07C17/12 , C07C37/62 , C07C41/22 , C07C209/74 , C07C253/30 , C25B1/24 , C25B3/06 , C07C25/18 , C07C25/22 , C07C211/52 , C07C255/50 , C07C39/27 , C07C43/225
Abstract: A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.
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公开(公告)号：US08242315B2
公开(公告)日：2012-08-14
申请号：US13274172
申请日：2011-10-14
Applicant: Thomas E. Jenkins
Inventor： Thomas E. Jenkins
CPC classification number: C07C39/06 , C07B2200/07 , C07C37/0555 , C07C39/27 , C07C271/44
Abstract: A (+)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.
Abstract translation: 式（I）的（+） - 立体异构体：其中X是H或F; 或其药学上可接受的盐或前药，用作麻醉剂。
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Patent Agency Ranking
公开(公告)号：US08173849B2
公开(公告)日：2012-05-08
申请号：US12596711
申请日：2008-05-08
Applicant: Thomas E. Jenkins
Inventor： Thomas E. Jenkins
IPC: C07C39/24 , C07C39/06 , C07C261/00 , A61K31/05
CPC classification number: C07C39/06 , A61K9/0019 , C07B2200/07 , C07C37/003 , C07C37/045 , C07C37/055 , C07C37/86 , C07C39/27 , C07C245/20 , C07C271/44 , C07C39/19
Abstract: A (−)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic.
Abstract translation: 式（I）的（ - ） - 立体异构体：（式I），其中X是H或F; 或其药学上可接受的盐或前药可用作麻醉剂。
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公开(公告)号：US08143271B2
公开(公告)日：2012-03-27
申请号：US13216200
申请日：2011-08-23
Applicant: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
Inventor： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
IPC: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC classification number: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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公开(公告)号：US20120035271A1
公开(公告)日：2012-02-09
申请号：US13274172
申请日：2011-10-14
Applicant: Thomas E. Jenkins
Inventor： Thomas E. Jenkins
CPC classification number: C07C39/06 , C07B2200/07 , C07C37/0555 , C07C39/27 , C07C271/44
Abstract: A (−)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.
Abstract translation: 式（I）的（ - ） - 立体异构体：[其中X为H或F的式（I） 或其药学上可接受的盐或前药，用作麻醉剂。
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公开(公告)号：US07973185B2
公开(公告)日：2011-07-05
申请号：US11577434
申请日：2005-12-07
Applicant: András Vass , József Dudás , László Borbély , Ferenc Haász , Péter Jekkel
Inventor： András Vass , József Dudás , László Borbély , Ferenc Haász , Péter Jekkel
IPC: C07J1/00
CPC classification number: C07C37/055 , C07C45/673 , C07C49/755 , C07C49/84 , C07C51/367 , C07C201/12 , C07C2602/10 , C07J1/0059 , C07J1/0074 , C07C65/03 , C07C65/10 , C07C39/04 , C07C39/14 , C07C39/07 , C07C39/28 , C07C39/27 , C07C39/08 , C07C39/17 , C07C205/22
Abstract: The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae R1 stands for straight chain or branched C1-6 alkyl group; R2, R3 , R4 , R5, and R6 have the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, C1-6 alkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or R2 and R3 together stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or C1-6 alkylcarbonyloxy group in the 17 position.
Abstract translation: 本发明涉及一种制备通式（I）的酚羟基取代的化合物的方法，该方法通过在所述的硫脲/氯化铝试剂对中用硫脲/氯化铝试剂对进行脱烷基处理来制备通式（Ⅱ）的烷基芳基醚 通式R1代表直链或支链C 1-6烷基; R2，R3，R4，R5和R6具有相同或不同的含义，代表氢或卤素原子，羟基，羧基，硝基，氧代，C1-6烷基羰基，直链或支链烷基或 - 烷氧基或芳基， 或R 2和R 3一起代表5-7元环或稠环体系; 所述5-7元环可以是任选被氧代基取代的部分饱和的环，或者可以是不饱和环; 或所述稠环体系可以与第一环一起构成类固醇，优选在17位任选被氧代或C 1-6烷基羰基氧基取代的雌三烯衍生物。
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公开(公告)号：US20100331567A1
公开(公告)日：2010-12-30
申请号：US12918001
申请日：2009-02-16
Applicant: Giovanni Battista Giovenzana , Camilla Cavallotti , Luciano Lattuada , Fulvio Uggeri
Inventor： Giovanni Battista Giovenzana , Camilla Cavallotti , Luciano Lattuada , Fulvio Uggeri
IPC: C07C69/88 , C07C235/60
CPC classification number: C07C51/363 , C07B39/00 , C07C37/62 , C07C67/307 , C07C231/12 , C07C237/46 , C25B3/06 , C07C65/03 , C07C69/88 , C07C235/48 , C07C39/27
Abstract: The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2,4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3,5-disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).
Abstract translation: 本发明涉及一种制备碘化酚的方法，特别涉及一种方法，其包括将式（1）的3,5-二取代的酚电化学碘化为相应的3,5-二取代的-2， 式（2）的4,6-三碘苯酚，其是用于合成x射线造影剂的有用的中间体，以及造影剂本身的制备。 此外，本发明包括式（6）的3,5-二取代的苯胺与式（7）的相应3,5-二取代-2,4,6-三碘苯胺的电化学碘化。
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