公开(公告)号：US20220177507A1

公开(公告)日：2022-06-09

申请号：US17599234

申请日：2020-02-07

申请人： NAGASE & CO., LTD. ,  THE KITASATO INSTITUTE

发明人： Wanjiao ZHANG ,  Kunio KOSAKA ,  Keisuke MATSUYAMA ,  Mami TANAKA ,  Masahiro SOTA

IPC分类号： C07H13/02 ,  A61K8/60 ,  A61Q19/00 ,  C12P19/12

摘要： It is an object of the present invention to provide a novel compound having an antioxidant effect and a technique of using the novel compound. The above object is achieved by providing a compound represented by the following formula (1): wherein any one of R1 to R3 is hydrogen, an acetyl group, a 2-butenoyl group, or a 2-methyl-2-pentenoyl group, each of the other two of R1 to R3 is hydrogen, any one of R4 to R6 is a 2-methyl-2-butenoyl group, and each of the other two of R4 to R6 is hydrogen.

公开(公告)号：US10364298B2

公开(公告)日：2019-07-30

申请号：US14358927

申请日：2012-11-16

申请人： National Research Council of Canada

发明人： Christopher Reid ,  Susan M. Logan ,  Evguenii Vinogradov ,  Andrew Cox ,  Jean-Robert Brisson

IPC分类号： C08B37/00 ,  A61K39/08 ,  C07H11/04 ,  C07H13/02 ,  C07H15/04 ,  C12Q1/04 ,  A61P31/04 ,  A61K39/00

摘要： A novel lipoteichoic acid (LTA) was isolated from C. difficile, the structure of which is illustrated below wherein n is an integer between 1 and 20, R3 and R4 are independently selected from C 14:0, C 16:0, C 16:1, C 18:0 or C18:1 fatty acid or any combination thereof wherein one of COR3 or COR4 may be replaced by H. Further described are conjugates comprising the novel LTA and vaccines produced using the isolated LTA and the LTA conjugates. The invention also encompasses methods of conferring immunity against C. difficile comprising administering a vaccine of the invention, and methods of detecting C. difficile using the isolated LTA of the invention.

公开(公告)号：US09005578B2

公开(公告)日：2015-04-14

申请号：US13903362

申请日：2013-05-28

申请人： The General Hospital Corporation ,  Fluoropharma, Inc.

发明人： David R. Elmaleh ,  Timothy M. Shoup ,  Hongning Fu

IPC分类号： A61K51/04 ,  C07C43/253 ,  C07D471/10 ,  C07H13/02 ,  C07H13/10 ,  C07H15/26

CPC分类号： A61K51/0497 ,  C07C43/192 ,  C07C43/196 ,  C07C43/253 ,  C07D471/10 ,  C07H13/02 ,  C07H13/10 ,  C07H15/26

摘要： One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

摘要翻译： 本发明的一个方面涉及用于诊断和/或治疗患有淀粉样变性相关病理状况的受试者的化合物，组合物和方法。 在某些实施方案中，本发明的成像和/或治疗剂可以施用于受试者以鉴定和/或治疗淀粉样沉积物。 具体的成像方法通过对受试者施用成像剂并检测试剂的空间分布来检测淀粉样蛋白沉积物。 药剂的差异积累是AD或淀粉样变性相关病理状态的指示，并且可以通过使用PET或SPECT照相机进行监测。

公开(公告)号：US20130315827A1

公开(公告)日：2013-11-28

申请号：US13903362

申请日：2013-05-28

申请人： Fluoropharma, Inc. ,  The General Hospital Corporation

发明人： David R. Elmaleh ,  Timothy M. Shoup ,  Hongning Fu

IPC分类号： A61K51/04 ,  C07C43/253 ,  C07D471/10 ,  C07H13/02

CPC分类号： A61K51/0497 ,  C07C43/192 ,  C07C43/196 ,  C07C43/253 ,  C07D471/10 ,  C07H13/02 ,  C07H13/10 ,  C07H15/26

摘要： One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

公开(公告)号：US20120272976A1

公开(公告)日：2012-11-01

申请号：US13095277

申请日：2011-04-27

申请人： Crystal Dawn Hege Byrd ,  Anthony Richard Gerardi ,  Michael Francis Dube

发明人： Crystal Dawn Hege Byrd ,  Anthony Richard Gerardi ,  Michael Francis Dube

IPC分类号： A24B15/34 ,  C07H13/02 ,  A24B15/26

CPC分类号： A24B15/241 ,  A24B13/00 ,  A24B15/24 ,  A24B15/26 ,  A24B15/30 ,  C07C35/02 ,  C07C35/21 ,  C07C35/36 ,  C07H1/08 ,  C07H3/04

摘要： The invention provides a method of extracting and isolating certain compounds from tobacco. The resulting isolate can include more than 90% by weight of a given compound and can be used as a flavor component for tobacco material used in smoking articles and smokeless tobacco compositions. Exemplary compounds that may be present in the isolate according to the invention include, but are not limited to, solanone, neophytadiene, megastigmatrienone, β-damascenone, norsolanadione, cis-abienol, α-cembratrienediol, β-cembratrienediol, sucrose esters, and lutein.

摘要翻译： 本发明提供从烟草中提取和分离某些化合物的方法。 所得到的分离物可以包含超过90重量％的给定化合物，并且可以用作用于吸烟制品和无烟烟草组合物的烟草材料的风味成分。 可存在于根据本发明的分离物中的示例性化合物包括但不限于：soloneone，neophytadiene，megastigmatrienone，＆amp; dascascenone，norsolanadione，cis-abienol，α-cembratrienediol，＆bgr。-cembratrienediol，蔗糖酯， 和叶黄素

公开(公告)号：US20110245196A1

公开(公告)日：2011-10-06

申请号：US12738552

申请日：2008-10-16

申请人： Vito Ferro ,  Karoli Tomislav ,  Liu Ligong ,  Handley Paul Newton ,  Johnstone Kenneth David ,  Norbert Wimmer ,  Hammond Edward Timothy

发明人： Vito Ferro ,  Karoli Tomislav ,  Liu Ligong ,  Handley Paul Newton ,  Johnstone Kenneth David ,  Norbert Wimmer ,  Hammond Edward Timothy

IPC分类号： A61K31/7016 ,  C07H13/02 ,  C07H13/00 ,  C07J31/00 ,  A61K31/7024 ,  A61K31/702 ,  A61P35/04 ,  A61P35/00 ,  A61P29/00 ,  A61P7/02 ,  A61P9/00 ,  A61P31/00 ,  A61P3/06

CPC分类号： C07J43/003 ,  C07H3/04 ,  C07H3/06 ,  C07H5/02 ,  C07H5/04 ,  C07H5/06 ,  C07H11/00 ,  C07H15/04 ,  C07H15/207 ,  C07H15/24 ,  C07H15/26 ,  C07H17/02 ,  C07J17/005 ,  C07J31/006 ,  C07J41/0088 ,  C07J41/0094

摘要： The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.

摘要翻译： 本发明涉及可用作硫酸乙酰肝素结合蛋白的抑制剂的新型化合物; 包含该化合物的组合物，以及该化合物及其组合物用于哺乳动物受试者的抗血管生成，抗转移，抗炎，抗微血管和/或抗血栓形成治疗的用途。

公开(公告)号：US07960351B2

公开(公告)日：2011-06-14

申请号：US12416803

申请日：2009-04-01

申请人： Markwart Kunz ,  Mohammad Munir ,  Manfred Vogel

发明人： Markwart Kunz ,  Mohammad Munir ,  Manfred Vogel

IPC分类号： A61K31/70 ,  C07H13/02

CPC分类号： C12Y301/01011 ,  A23L29/231 ,  A61K31/732 ,  C08B37/0045 ,  C12P19/04 ,  C12Y302/01015 ,  C12Y402/0201

摘要： Methods for the production of pectin hydrolysis products, the pectin hydrolysis products produced in this manner, as well as their use are described.

摘要翻译： 生产果胶水解产物的方法，以这种方式生产的果胶水解产物及其用途进行了描述。

公开(公告)号：US20110123768A1

公开(公告)日：2011-05-26

申请号：US12954041

申请日：2010-11-24

申请人： Jun TAKEDA ,  Keiji Mihayashi

发明人： Jun TAKEDA ,  Keiji Mihayashi

IPC分类号： B32B3/30 ,  C07H13/02 ,  C08L1/10 ,  B32B23/20 ,  B29D7/01

CPC分类号： B29C41/24 ,  B29C41/32 ,  B29C55/08 ,  B29K2001/00 ,  B29K2001/12 ,  B29K2105/16 ,  B29K2995/0026 ,  B29K2995/0034 ,  B32B23/20 ,  C08B3/00 ,  C08B3/06 ,  C08L1/10 ,  C08L1/12 ,  Y10T428/24355 ,  Y10T428/31986

摘要： A plastic film having an internal haze of at most 0.08 and a total haze of at least 0.41 is, when attached to a polarizer and incorporated in a display device as a retardation film therein, effective for bettering the contrast of the device, and has good film handling characteristics during transport.

摘要翻译： 具有至多0.08的内部雾度和至少0.41的总雾度的塑料膜当附接到偏振器并且结合在作为其中的相位差膜的显示装置中时，有效地改善了装置的对比度，并且具有良好的 运输过程中的胶片处理特性。

公开(公告)号：US20110065656A1

公开(公告)日：2011-03-17

申请号：US12888222

申请日：2010-09-22

申请人： Keith Frank Martin ,  David John Heal

发明人： Keith Frank Martin ,  David John Heal

IPC分类号： A61K31/7024 ,  A61K31/19 ,  C07C59/01 ,  C07C59/195 ,  A61K31/20 ,  C07C57/02 ,  C07C31/20 ,  A61K31/047 ,  C07H13/02 ,  A61P25/16

CPC分类号： A61K31/19 ,  A61K31/047 ,  A61K31/192 ,  A61K31/20 ,  A61K31/22 ,  A61K31/23 ,  A61K45/06

摘要： A method is described for providing acute symptomatic relief to a subject with Parkinson's Disease (PD) or other CNS disorders resulting from dopamine deficiency in the brain comprising administering to said subject an amount of a ketogenic material sufficient to produce a ketosis in the subject sufficient to provide therapeutic benefit in such neurological disorders. Preferred materials produce a ketosis is such that the total concentration of acetoacetate and (R)-3-hydroxybutyrate in the blood of the subject is raised to between 0.1 and 30 mM.

摘要翻译： 描述了一种用于向患有帕金森病（PD）或由脑中多巴胺缺乏引起的其他CNS障碍的受试者提供急性症状缓解的方法，包括向所述受试者施用足以产生足以在受试者中产生酮症的量的酮生成物质 在这种神经障碍中提供治疗益处。 优选的材料产生酮症使得受试者血液中乙酰乙酸酯和（R）-3-羟基丁酸酯的总浓度升高至0.1至30mM。

公开(公告)号：US20070293439A1

公开(公告)日：2007-12-20

申请号：US11575938

申请日：2005-09-23

申请人： Xiazhuo Chen ,  Klaus Himmeldirk ,  Yulin Ren

发明人： Xiazhuo Chen ,  Klaus Himmeldirk ,  Yulin Ren

IPC分类号： A61K31/70 ,  A61P3/00 ,  C07H13/02

CPC分类号： C07H13/08

摘要： Methods of treating hyperglycemic, hyperlipidemic, and hyperinsulinemic disorders are provided. Compositions for treating such disorders are also provided. The compositions can include hexose and pentose variants having acid moieties and a substituent Y linked to the six position of a hexose or the five position of the pentose.

摘要翻译： 提供了治疗高血糖，高脂血症和高胰岛素血症的方法。 还提供了用于治疗这种疾病的组合物。 组合物可以包括具有酸部分的己糖和戊糖变体以及连接到己糖的六个位置或戊糖的五个位置的取代基Y。