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公开(公告)号：US20220202837A1
公开(公告)日：2022-06-30
申请号：US17672508
申请日：2022-02-15
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Nicholas J. Agard , Jennifer A. Prescher , Jeremy Michael Baskin , Ellen May Sletten
IPC: A61K31/655 , C07C45/29 , C07C45/51 , C07C45/63 , C07C49/457 , C07C49/753 , C07C59/72 , C07C63/66 , C07C69/708 , C07C69/76 , C07D207/416 , C07D207/452 , C07D249/16 , C07D495/04 , G01N33/531 , G01N33/68 , C07C63/74 , C07C57/26
Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
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公开(公告)号：US10010629B2
公开(公告)日：2018-07-03
申请号：US14806207
申请日：2015-07-22
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Andreas Stahl , Amy Helene Fluitt , Elena A. Dubikovskaya , Allison Cohen
IPC: A61K49/00 , A61K51/04 , C07D257/02 , C07D277/28 , C07D277/64 , C07D417/04 , C07D487/04 , C12Q1/66
CPC classification number: A61K49/0052 , A61K51/0453 , A61K51/0482 , C07D257/02 , C07D277/28 , C07D277/64 , C07D417/04 , C07D487/04 , C12Q1/66
Abstract: The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
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公开(公告)号：US20150343094A1
公开(公告)日：2015-12-03
申请号：US14806207
申请日：2015-07-22
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Andreas Stahl , Amy Helene Henkin , Elena A. Dubikovskaya , Allison Cohen
IPC: A61K49/00 , C12Q1/66 , C07D277/64 , C07D257/02 , A61K51/04
CPC classification number: A61K49/0052 , A61K51/0453 , A61K51/0482 , C07D257/02 , C07D277/28 , C07D277/64 , C07D417/04 , C07D487/04 , C12Q1/66
Abstract: The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
Abstract translation: 本公开提供了脂质 - 探针化合物和包含该化合物的组合物。 主题脂质 - 探针化合物对于也提供的各种成像应用是有用的。
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公开(公告)号：US20130344527A1
公开(公告)日：2013-12-26
申请号：US13868444
申请日：2013-04-23
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Nicholas J. Agard , Jennifer A. Prescher , Jeremy Michael Baskin , Ellen May Sletten
CPC classification number: A61K31/655 , C07C45/292 , C07C45/511 , C07C45/63 , C07C49/457 , C07C49/753 , C07C57/26 , C07C59/72 , C07C63/66 , C07C63/74 , C07C69/708 , C07C69/76 , C07C2601/18 , C07D207/416 , C07D207/452 , C07D249/16 , C07D495/04 , G01N33/531 , G01N33/6803 , G01N33/6842 , C07C49/573
Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
Abstract translation: 本发明提供改性环炔化合物; 以及这些化合物在修饰生物分子中的使用方法。 本发明的特征在于可以在生理条件下进行的环加成反应。 通常，本发明涉及使改性的环炔与靶生物分子上的叠氮化物部分反应，产生共价修饰的生物分子。 反应的选择性及其与水性环境的相容性使其在体内（例如，在细胞表面或细胞内）和体外（例如，肽和其它聚合物的合成，生物修饰（例如，标记的）氨基酸 ）。
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公开(公告)号：US12048710B2
公开(公告)日：2024-07-30
申请号：US17672508
申请日：2022-02-15
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Nicholas J. Agard , Jennifer A. Prescher , Jeremy Michael Baskin , Ellen May Sletten
IPC: G01N33/531 , A61K31/655 , C07C45/29 , C07C45/51 , C07C45/63 , C07C49/457 , C07C49/753 , C07C57/26 , C07C59/72 , C07C63/66 , C07C63/74 , C07C69/708 , C07C69/76 , C07D207/416 , C07D207/452 , C07D225/02 , C07D249/16 , C07D495/04 , G01N33/68
CPC classification number: A61K31/655 , C07C45/292 , C07C45/511 , C07C45/63 , C07C49/457 , C07C49/753 , C07C57/26 , C07C59/72 , C07C63/66 , C07C63/74 , C07C69/708 , C07C69/76 , C07D207/416 , C07D207/452 , C07D225/02 , C07D249/16 , C07D495/04 , G01N33/531 , G01N33/6803 , G01N33/6842 , C07C2601/18 , C07C45/292 , C07C49/753 , C07C45/511 , C07C49/457 , C07C45/511 , C07C49/753 , C07C45/511 , C07C49/573 , C07C45/63 , C07C49/457
Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
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Patent Agency Ranking
公开(公告)号：US20210024614A1
公开(公告)日：2021-01-28
申请号：US16927641
申请日：2020-07-13
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
IPC: C07K16/00 , C07K1/00 , C07K1/13 , C12P21/00 , C07K1/107 , C07K14/00 , C07K16/46 , C12N9/96 , C07K14/35 , C07K14/565 , C12N9/10 , A61K38/18 , A61K38/21 , A61K38/37 , A61K38/45 , A61K39/00
Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
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公开(公告)号：US20200046742A1
公开(公告)日：2020-02-13
申请号：US16595002
申请日：2019-10-07
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Nicholas J. Agard , Jennifer A. Prescher , Jeremy Michael Baskin , Ellen May Sletten
IPC: A61K31/655 , C07C45/29 , C07C45/51 , C07C45/63 , C07C49/457 , C07C49/753 , C07C59/72 , C07C63/66 , C07C69/708 , C07C69/76 , C07D207/416 , C07D207/452 , C07D249/16 , C07D495/04 , G01N33/531 , G01N33/68 , C07C63/74 , C07C57/26
Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
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公开(公告)号：US20170121389A1
公开(公告)日：2017-05-04
申请号：US15238158
申请日：2016-08-16
Applicant: The Regents of the University of California
Inventor： Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Ruth Bertozzi
CPC classification number: C07K16/00 , A61K38/1825 , A61K38/215 , A61K38/37 , A61K38/45 , A61K39/00 , C07K1/006 , C07K1/1072 , C07K1/13 , C07K14/00 , C07K14/35 , C07K14/565 , C07K16/46 , C07K2317/24 , C07K2317/40 , C07K2317/52 , C07K2317/622 , C12N9/13 , C12N9/96 , C12P21/00 , C12P21/005 , C12Y208/02
Abstract: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
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公开(公告)号：US11278554B2
公开(公告)日：2022-03-22
申请号：US16595002
申请日：2019-10-07
Applicant: The Regents of the University of California
Inventor： Carolyn Ruth Bertozzi , Nicholas J. Agard , Jennifer A. Prescher , Jeremy Michael Baskin , Ellen May Sletten
IPC: A61K31/655 , G01N33/531 , G01N33/68 , C07C45/29 , C07C45/51 , C07C45/63 , C07C49/457 , C07C49/753 , C07C59/72 , C07C63/66 , C07C69/708 , C07C69/76 , C07D207/416 , C07D207/452 , C07D249/16 , C07D495/04 , C07C63/74 , C07C57/26
Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
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公开(公告)号：US20190389817A1
公开(公告)日：2019-12-26
申请号：US16422687
申请日：2019-05-24
Applicant: The Regents of the University of California
Inventor： Ellen May Sletten , Carolyn Ruth Bertozzi
IPC: C07D249/12 , C07D495/04 , C07F15/04 , C07C245/04 , C07C69/76 , C07D339/06 , C07C49/04 , C07C49/76 , C07C69/013 , C12N5/071 , G01N33/50 , C07D225/02 , C07D249/04 , C07C271/42 , C07C69/96 , C07C323/16 , C07C323/56 , C07C323/64 , C07C255/46 , C07D405/12
Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.
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