公开(公告)号：US20120196939A1

公开(公告)日：2012-08-02

申请号：US13437802

申请日：2012-04-02

Applicant: Thomas E. Jenkins

Inventor： Thomas E. Jenkins

IPC: A61K31/05 ,  A61P25/20 ,  C07C271/42 ,  C07C39/06 ,  C07C39/27

CPC classification number: C07C39/06 ,  A61K9/0019 ,  C07B2200/07 ,  C07C37/003 ,  C07C37/045 ,  C07C37/055 ,  C07C37/86 ,  C07C39/27 ,  C07C245/20 ,  C07C271/44 ,  C07C39/19

Abstract: A (−)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or pro drug thereof, is useful as an anesthetic.

Abstract translation: 式（I）的（ - ） - 立体异构体：（式I），其中X是H或F; 或其药学上可接受的盐或其前药可用作麻醉剂。

公开(公告)号：US20050096387A1

公开(公告)日：2005-05-05

申请号：US10969796

申请日：2004-10-19

Applicant: Jeroen Verheijen ,  ShouCheng Du

Inventor： Jeroen Verheijen ,  ShouCheng Du

IPC: C07C271/40 ,  C07C271/42 ,  C07C271/44 ,  C07C271/48 ,  C07D213/64 ,  C07D487/04 ,  C07D519/00 ,  A61K31/325

CPC classification number: C07C271/42 ,  C07C271/44 ,  C07C271/48 ,  C07D213/64 ,  C07D487/04

Abstract: Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: wherein A is selected from the group consisting of an unsubstituted aryl, a substituted aryl, an unsubstituted heteroaryl and a substituted heteroaryl. The carbamoyl esters are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the carbamoyl esters can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.

Abstract translation: 氨基甲酰酯抑制胆碱酯酶活性，并且在水解时释放药理活性剂。 在一个实施方案中，氨基甲酰酯具有以下结构：其中A选自未取代的芳基，取代的芳基，未取代的杂芳基和取代的杂芳基。 氨基甲酰酯用于治疗个体的方法。 通过水解氨基甲酰酯获得的药理学活性剂可以治疗例如神经系统状况，胆碱能缺乏以及与药理活性剂如乙酰胆碱缺乏相关的病症或疾病。

公开(公告)号：US5925674A

公开(公告)日：1999-07-20

申请号：US548403

申请日：1995-10-26

Applicant: Bernd-Wieland Krueger ,  Klaus Sasse ,  Thomas Schenke ,  Michael Negele ,  Heinz-Wilhelm Dehne

Inventor： Bernd-Wieland Krueger ,  Klaus Sasse ,  Thomas Schenke ,  Michael Negele ,  Heinz-Wilhelm Dehne

IPC: A01N37/24 ,  A01N47/06 ,  A01N47/22 ,  C07C233/60 ,  C07C271/48 ,  C07C323/18 ,  C07C323/31 ,  C07C329/06 ,  A01N47/10 ,  C07C271/42

CPC classification number: C07C233/60 ,  A01N37/24 ,  A01N47/06 ,  A01N47/22 ,  C07C271/48 ,  C07C329/06 ,  C07C2101/08 ,  C07C2101/14

Abstract: This invention relates to cycloalkylcarboxanilides of the formula ##STR1## which are used to combat pests.

Abstract translation: 本发明涉及用于防治害虫的下式的环烷基甲酰苯胺。

公开(公告)号：US5658944A

公开(公告)日：1997-08-19

申请号：US421997

申请日：1995-04-14

Applicant: James Mood Chapman, Jr. ,  Roy Lee Hawke ,  Karl Witold Franzmann ,  Kevin Julian O'Connor

Inventor： James Mood Chapman, Jr. ,  Roy Lee Hawke ,  Karl Witold Franzmann ,  Kevin Julian O'Connor

IPC: A61K31/12 ,  A61K31/00 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07C49/20 ,  C07C59/125 ,  C07C69/712 ,  C07C69/716 ,  C07C229/14 ,  C07C233/29 ,  C07C235/34 ,  C07C271/42 ,  C07C273/18 ,  C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C323/18 ,  C07C323/31 ,  C07C323/62 ,  C12N9/99 ,  A61K31/27 ,  C07C229/00 ,  C07C233/01 ,  C07C275/02

CPC classification number: C07C275/28 ,  C07C275/30 ,  C07C275/34

Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein Ar is a mono- or bicyclic aromatic group optionally containing one or two heteroatoms independently selected from nitrogen, oxygen and sulphur, said group being optionally substituted by one or more atoms or groups independently selected from halogen, nitro, amino, --NRR.sup.1 where R and R.sup.1 are independently selected from hydrogen, C.sub.1-8 alkyl and C.sub.1-8 alkanoyl, cyano, carboxyalkoxy, alkoxycarbonylalkoxy, C.sub.1-8 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.1-8 alkoxy (including cycloalkoxy and cycloalkylalkoxy), C.sub.1-8 thioalkyl, said alkyl, alkoxy and/or thioalkyl group(s) being optionally substituted by one or more halogen atoms, aryl, aryloxy, aralkyl and aralkyloxy, said aryl, aryloxy, aralkyl and/or aralkyloxy group(s) being optionally substituted by one or more atoms or groups independently selected from halogen, alkyl, alkoxy, alkanoyl, hydroxyalkyl, perfluoroalkyl, perfluoroalkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, and C.sub.3-8 polyether groups containing from one to three oxygen atoms;D is --CH.sub.2 --, --NH--, or --O--;E is --N

公开(公告)号：US5349048A

公开(公告)日：1994-09-20

申请号：US173233

申请日：1993-12-27

Applicant: William D. McGhee ,  Dennis P. Riley

Inventor： William D. McGhee ,  Dennis P. Riley

IPC: C07C68/04 ,  C07C69/96 ,  C07C269/04 ,  C07C271/06 ,  C07C271/12 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07C271/38 ,  C07C271/42 ,  C07D295/20 ,  C08G64/32 ,  C08G71/04 ,  C08G65/34 ,  C08G67/02

CPC classification number: C07C269/04 ,  C07C68/04 ,  C08G64/323 ,  C08G71/04

Abstract: The present invention provides a process for preparing urethanes and carbonates from an amine or an alcohol, carbon dioxide and a hydrocarbyl halide. The amine or alcohol is reacted with carbon dioxide in a suitable solvent system and in the presence of an amidine or guanidine base, to form the ammonium carbamate or carbonate salt which is then reacted in a polar aprotic solvent with a hydrocarbyl halide. Polymer products can also be prepared utilizing this process or utilizing the resulting urethanes and carbonates under standard polymerization conditions.

Abstract translation: 本发明提供了由胺或醇，二氧化碳和烃基卤化物制备氨基甲酸酯和碳酸酯的方法。 胺或醇在合适的溶剂体系中和在脒或胍碱的存在下与二氧化碳反应，形成氨基甲酸铵或碳酸盐，然后在极性非质子溶剂中与烃基卤化物反应。 也可以使用该方法制备聚合物产物，或者在标准聚合条件下利用所得的聚氨酯和碳酸酯。

公开(公告)号：US4396418A

公开(公告)日：1983-08-02

申请号：US259543

申请日：1981-05-01

Applicant: Ulrich Schirmer ,  Rainer Becker ,  Bruno Wuerzer ,  Guenter Retzlaff

Inventor： Ulrich Schirmer ,  Rainer Becker ,  Bruno Wuerzer ,  Guenter Retzlaff

IPC: A01N47/20 ,  A01P13/00 ,  C07C67/00 ,  C07C239/00 ,  C07C271/28 ,  C07C271/42 ,  C07C271/48 ,  C07C313/00 ,  C07C315/04 ,  C07C317/22 ,  C07C317/42 ,  C07C323/43 ,  C07C325/00 ,  C07C333/08 ,  C07C155/02 ,  A01N31/14 ,  A01N37/44 ,  C07C125/06

CPC classification number: A01N47/20

Abstract: N-aryl(thiol)carbamates of the formula ##STR1## where X denotes hydrogen, fluorine, bromine, iodine, alkyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenyl or benzyloxy, Y denotes hydrogen, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenyl or benzyloxy, n denotes one of the integers 1 and 2, Z denotes hydrogen, halogen or trifluoromethyl, A denotes oxygen, sulfur, sulfinyl or sulfonyl, and Q denotes oxygen or sulfur, and their use for combating unwanted plant growth.

Abstract translation: 式（I）的N-芳基（硫醇）氨基甲酸酯，其中X表示1至6个碳原子的氢，氟，溴，碘，烷基，烷氧基，卤代烷基，卤代烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基， 苯基或苄氧基，Y表示氢，卤素，烷基，烷氧基，卤代烷基，卤代烷氧基，烷硫基，烷基亚磺酰基或具有1至6个碳原子的烷基磺酰基，3至6个碳原子的环烷基，苯基或苄氧基，n表示一个 的整数1和2，Z表示氢，卤素或三氟甲基，A表示氧，硫，亚磺酰基或磺酰基，Q表示氧或硫，以及它们用于抵抗不想要的植物生长的用途。

公开(公告)号：US20190389817A1

公开(公告)日：2019-12-26

申请号：US16422687

申请日：2019-05-24

Applicant: The Regents of the University of California

Inventor： Ellen May Sletten ,  Carolyn Ruth Bertozzi

IPC: C07D249/12 ,  C07D495/04 ,  C07F15/04 ,  C07C245/04 ,  C07C69/76 ,  C07D339/06 ,  C07C49/04 ,  C07C49/76 ,  C07C69/013 ,  C12N5/071 ,  G01N33/50 ,  C07D225/02 ,  C07D249/04 ,  C07C271/42 ,  C07C69/96 ,  C07C323/16 ,  C07C323/56 ,  C07C323/64 ,  C07C255/46 ,  C07D405/12

Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.

公开(公告)号：US10301270B2

公开(公告)日：2019-05-28

申请号：US15409354

申请日：2017-01-18

Applicant: The Regents of the University of California

Inventor： Ellen May Sletten ,  Carolyn Ruth Bertozzi

IPC: C07C69/96 ,  C07C271/42 ,  C07C49/04 ,  C07C49/76 ,  C07C69/76 ,  C07F15/04 ,  C12N5/071 ,  G01N33/50 ,  C07C245/04 ,  C07C255/46 ,  C07C323/16 ,  C07C323/56 ,  C07C323/64 ,  C07C69/013 ,  C07D225/02 ,  C07D249/04 ,  C07D249/12 ,  C07D339/06 ,  C07D405/12 ,  C07D495/04

Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.

公开(公告)号：US10081701B2

公开(公告)日：2018-09-25

申请号：US14472663

申请日：2014-08-29

Applicant: FUJIFILM Corporation

Inventor： Toshihide Aoshima ,  Kazutoshi Katayama

IPC: C08G18/32 ,  C08G18/76 ,  C08G18/80 ,  C08G18/75 ,  C08G18/72 ,  G11B5/702 ,  C07C271/40 ,  C07C271/42 ,  C07C271/56 ,  C07C271/58

CPC classification number: C08G18/3215 ,  C07C271/40 ,  C07C271/42 ,  C07C271/56 ,  C07C271/58 ,  C08G18/724 ,  C08G18/755 ,  C08G18/757 ,  C08G18/7621 ,  C08G18/7642 ,  C08G18/8016 ,  C08G18/8019 ,  C08G18/8025 ,  C08G18/8029 ,  G11B5/7021

Abstract: An aspect of the present invention relates to a composition, which is a composition for a magnetic recording medium and comprises an isocyanate compound in the form of an adduct of a polyhydroxyl compound having one or more aromatic carbon rings and three or more hydroxyl groups per molecule with a polyisocyanate having two or more isocyanate groups per molecule.

公开(公告)号：US20100221809A1

公开(公告)日：2010-09-02

申请号：US12638806

申请日：2009-12-15

Applicant: Henry J. Forman ,  Matthew P. Meyer

Inventor： Henry J. Forman ,  Matthew P. Meyer

IPC: C12N9/20 ,  C07C271/42 ,  C07C327/02 ,  C07F9/02 ,  C07C381/00

CPC classification number: C12N9/16 ,  C07B2200/11 ,  C07C271/34 ,  C07C329/12 ,  C07C333/04 ,  C07C391/00 ,  C07C2602/42 ,  C07C2603/68 ,  C07F9/117 ,  C12Y301/04003

Abstract: This invention is directed to compositions and methods for the isolation and further characterization of eukaryotic, mammalian, and/or human PC-PLC. In addition, the present invention discloses methods for the synthesis of an affinity chromatography resin for the isolation and purification of biologically active proteins, including eukaryotic PC-PLC.

Abstract translation: 本发明涉及用于分离和进一步表征真核，哺乳动物和/或人PC-PLC的组合物和方法。 此外，本发明公开了合成用于分离和纯化包括真核PC-PLC的生物活性蛋白质的亲和层析树脂的方法。