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    Lysine compounds and their use in site- and chemoselective modification of peptides and proteins
    4.
    发明授权
    Lysine compounds and their use in site- and chemoselective modification of peptides and proteins 有权
    赖氨酸化合物及其在肽和蛋白质的位置和化学选择性修饰中的应用

    公开(公告)号：US08729009B2

    公开(公告)日：2014-05-20

    申请号：US13320686

    申请日：2010-05-12

    申请人： Huib Ovaa ,  Farid El Oualid

    发明人： Huib Ovaa ,  Farid El Oualid

    IPC分类号： A61K38/02 ,  C07K2/00 ,  C07C319/24 ,  C12P21/00 ,  G01N21/00 ,  C07C323/60 ,  C07K1/06

    CPC分类号： A61K38/02 ,  C07C271/22 ,  C07C323/59 ,  C07C391/00 ,  C07C2603/18 ,  C07K1/02

    摘要： The present invention concerns new thiolysine and selenolysine compounds that can be used as building blocks for peptides and proteins, providing ligation handles for site- and chemoselective modification of said peptides and proteins. In particular, the invention provides. In particular, the invention provides (the use of) the compounds 5-thiolysine (also referred to as δ-thiolysine); 4-thiolysine (also referred to as γ-thiolysine); 5-selenolysine (also referred to as δ-selenolysine) and 4-selenolysine (also referred to as γ-selenolysine). The positioning of the thiol or selenol group at the respective carbon atom allows for a very efficient intramolecular transfer reaction to take place after conjugation with a selected ligand, and the thiol or selenol group may subsequently be removed using reported procedures, thereby restoring the native lysine structure, or be used as an additional conjugation handle. The methodology is fast and gives well-defined material.

    摘要翻译： 本发明涉及可用作肽和蛋白质的结构单元的新的硫代赖氨酸和硒代赖氨酸化合物，提供用于所述肽和蛋白质的位点和化学选择性修饰的连接手柄。 具体地，本发明提供。 特别地，本发明提供化合物5-硫代赖氨酸（也称为δ-硫代赖氨酸）的用途（的用途）。 4-硫代赖氨酸（也称为γ-硫代赖氨酸）; 5-硒代赖氨酸（也称为δ-硒代赖氨酸）和4-硒代赖氨酸（也称为γ-硒代赖氨酸）。 硫醇或硒醇基团在相应碳原子上的定位允许在与所选择的配体缀合之后进行非常有效的分子内转移反应，并且随后可以使用报道的方法除去硫醇或硒酚基团，由此恢复天然赖氨酸 结构，或用作附加共轭手柄。 该方法很快，并提供了明确的材料。

    ORGANIC SEMICONDUCTOR COMPOUND, SEMICONDUCTOR DEVICE, SOLAR CELL AND PRODUCING METHOD OF ORGANIC SEMICONDUCTOR COMPOUND
    5.
    发明申请
    ORGANIC SEMICONDUCTOR COMPOUND, SEMICONDUCTOR DEVICE, SOLAR CELL AND PRODUCING METHOD OF ORGANIC SEMICONDUCTOR COMPOUND 失效
    有机半导体化合物，半导体器件，太阳能电池和有机半导体化合物的制造方法

    公开(公告)号：US20140012017A1

    公开(公告)日：2014-01-09

    申请号：US13926310

    申请日：2013-06-25

    申请人： National Institute for Materials Science

    发明人： Kazuhiko SAIGO ,  Yuka KOBAYASHI

    IPC分类号： H01L51/00

    CPC分类号： C07C391/00 ,  C07D339/06 ,  H01L51/0068 ,  H01L51/0074 ,  H01L51/4293 ,  Y02E10/549 ,  Y02P70/521

    摘要： There is provided a compound or the like which can become a material in which many functions are controllable. A first aspect of the present invention lies in an organic semiconductor compound, characterized in that an organic molecule which becomes a donor is formed by being salt-formed with an inorganic acid or an inorganic base and self assembly is accomplished. According to this configuration, there can be obtained an organic semiconductor compound by a simple technique. A second aspect of the present invention lies in an organic compound, characterized in that a compound containing a tetrathiafulvalene affinity region in a framework thereof and having a protic acid functional group is formed by being induced to a salt with ammonia or a salt with hydroxyamine. According to this configuration, there can be obtained an organic compound in which many functions are controllable.

    摘要翻译： 提供了可以成为许多功能是可控的材料的化合物等。 本发明的第一方面在于有机半导体化合物，其特征在于，通过与无机酸或无机碱形成盐而形成成为供体的有机分子，并进行自组装。 根据该结构，可以通过简单的技术得到有机半导体化合物。 本发明的第二方面在于一种有机化合物，其特征在于，在其骨架中含有四硫富瓦烯亲和性区域并具有质子酸官能团的化合物通过与氨或与羟基胺形成盐形成。 根据该结构，可以得到许多功能是可控的有机化合物。

    Organic semiconductor compound, semiconductor element, solar battery, and process for producing organic semiconductor compound
    8.
    发明授权
    Organic semiconductor compound, semiconductor element, solar battery, and process for producing organic semiconductor compound 失效
    有机半导体化合物，半导体元件，太阳能电池以及有机半导体化合物的制造方法

    公开(公告)号：US08501801B2

    公开(公告)日：2013-08-06

    申请号：US12867821

    申请日：2009-02-15

    申请人： Kazuhiko Saigo ,  Yuka Kobayashi

    发明人： Kazuhiko Saigo ,  Yuka Kobayashi

    IPC分类号： A61K31/385 ,  C07D339/06

    CPC分类号： C07C391/00 ,  C07D339/06 ,  H01L51/0068 ,  H01L51/0074 ,  H01L51/4293 ,  Y02E10/549 ,  Y02P70/521

    摘要： Disclosed is, for example, a compound that can be a material which can control many functions. According to a first aspect of the present invention, there is provided an organic semiconductor compound characterized in that the organic semiconductor compound is produced by forming a salt of organic molecules as a donor with an inorganic acid or an inorganic base and causes self-accumulation. According to the above constitution, the organic semiconductor compound can be obtained in a simple manner. According to a second aspect of the present invention, there is provided an organic compound characterized by being produced by deriving an ammonia salt or a hydroxyamine salt from a compound having a tetrathiafulvalene analogue site in the skeleton thereof and containing a protonic acid functional group. According to the above constitution, an organic compound which can control many functions can be obtained.

    摘要翻译： 公开了例如可以是可以控制许多功能的材料的化合物。 根据本发明的第一方面，提供了一种有机半导体化合物，其特征在于有机半导体化合物通过用无机酸或无机碱形成作为供体的有机分子的盐而产生，并引起自聚集。 根据上述结构，可以简单地获得有机半导体化合物。 根据本发明的第二方面，提供一种有机化合物，其特征在于通过在其骨架中衍生出具有四硫富瓦烯类似物位点的化合物并含有质子酸官能团的氨盐或羟胺盐产生。 根据上述结构，可以获得能够控制许多功能的有机化合物。