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    Use of 2-pentanone and specific receptor thereof in manufacture of products regulating cell functions
    1.
    发明公开
    Use of 2-pentanone and specific receptor thereof in manufacture of products regulating cell functions 审中-公开

    公开(公告)号：US20230234906A1

    公开(公告)日：2023-07-27

    申请号：US17817010

    申请日：2022-08-03

    Applicant: Taihe Hospital, Hubei University of Medicine

    Inventor： Changbin KE ,  Yanqiong WU ,  Shanchun SU ,  Xueqin XU

    IPC: C07C49/20

    CPC classification number: C07C49/20

    Abstract: Use of 2-pentanone and specific receptor thereof in a manufacture of a product regulating a cell function, a regulation of cell function, a manufacture of a product promoting an increase in an intracellular calcium ion concentration, or a manufacture of a product promoting an increase in a neuronal firing rate is provided. In the present disclosure, the specific receptor of 2-pentanone is expressed in cultured cells or animals, and its specific binding to 2-pentanone opens ligand-gated cation channels, resulting in an increase of intracellular calcium ion concentration, depolarization of cell membranes, and generation of electrical activity or endocrine activity, thereby finally achieving precise regulation of tissue cells and organ functions. After being treated, cells can be activated rapidly, producing effects with a rapid onset; once the treatment is stopped, the experimental effect can be quickly terminated to allow the cells to return to their original state quickly.

    Reagents and method for conjugating biological molecules
    2.
    发明授权
    Reagents and method for conjugating biological molecules 有权
    用于共轭生物分子的试剂和方法

    公开(公告)号：US08969626B2

    公开(公告)日：2015-03-03

    申请号：US13055455

    申请日：2009-07-17

    Applicant: Antony Godwin

    Inventor： Antony Godwin

    IPC: C07C49/20 ,  C07C233/73 ,  A61K47/48

    CPC classification number: C07C317/50 ,  A61K47/60 ,  C07C49/20 ,  C07C233/73 ,  C07C317/32 ,  C07D295/155

    Abstract: A compound of the general formula X-[Q-W—(CH═CH)n—(CH2)2-L]m (I) in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing group; n represents 0 or an integer of from 1 to 4; L represents a leaving group; and m represent an integer of from 1 to 8. The compounds find use in the conjugation of biological molecules.

    Abstract translation: 通式X- [Q-W-（CH = CH）n-（CH 2）2 -L] m（I）的化合物，其中X表示聚合物; Q表示连接基团; W表示吸电子基团; n表示0或1至4的整数; L表示离去基团; m表示1至8的整数。化合物用于生物分子的缀合。

    Manufacture of gamma-delta-unsaturated ketones
    4.
    发明授权
    Manufacture of gamma-delta-unsaturated ketones 有权
    制造γ-δ-不饱和酮

    公开(公告)号：US08664450B2

    公开(公告)日：2014-03-04

    申请号：US13125083

    申请日：2009-09-28

    Applicant: Fabrice Aquino ,  Werner Bonrath ,  Rolf Kuenzi

    Inventor： Fabrice Aquino ,  Werner Bonrath ,  Rolf Kuenzi

    IPC: C07C49/20

    CPC classification number: C07C45/511 ,  C07C49/203

    Abstract: A process for the manufacture of gamma-delta-unsaturated ketones of formula (R1)(R2)C═CH—CH2—CH2—CO—R3 (I), wherein R1 is methyl or ethyl; R2 is a saturated or unsaturated linear or cyclic hydrocarbon residue and R3 is methyl or ethyl, by reacting a tertiary vinyl carbinol of formula (R1)(R2)C(OH)—CH═CH2 (II) with an isopropenyl methyl or ethyl ether of formula H3C—C(OR3)═CH2 (III) in the pre-sence of an ammonium salt as catalyst.

    Abstract translation: 制备式（R1）（R2）C = CH-CH2-CH2-CO-R3（Ⅰ）的γ-δ-不饱和酮的方法，其中R1是甲基或乙基; 通过使式（R1）（R2）C（OH）-CH = CH2（II）的叔乙烯基甲醇与异丙烯基甲基或乙基醚反应，R2是饱和或不饱和的直链或环状烃残基，R3是甲基或乙基 的式IIIC-C（OR3）= CH2（Ⅲ）的铵盐作为催化剂。

    Method for the production of .gamma., .delta.-unsaturated ketones by reacting tertiary allyl alcohols with alkenyl alkyl ethers
    6.
    发明授权
    Method for the production of .gamma., .delta.-unsaturated ketones by reacting tertiary allyl alcohols with alkenyl alkyl ethers 失效
    通过使叔烯丙基醇与链烯基烷基醚反应生产γ，β-不饱和酮的方法

    公开(公告)号：US06034279A

    公开(公告)日：2000-03-07

    申请号：US147597

    申请日：1999-01-29

    Applicant: Stefan Kashammer ,  Detlef Ruff

    Inventor： Stefan Kashammer ,  Detlef Ruff

    IPC: B01J31/02 ,  C07B61/00 ,  C07C45/45 ,  C07C45/51 ,  C07C49/20 ,  C07C49/203 ,  C07C45/48

    CPC classification number: C07C403/16 ,  C07C45/513 ,  C07C2101/14

    Abstract: An improved process is described for preparing .gamma.,.delta.-unsaturated ke-tones, which are in demand as aroma substances and intermediates for vitamins and carotenoids, by reacting tertiary allyl alcohols and alkenyl alkyl ethers in the presence of acid catalysts at elevated temperature, which comprises carrying out the reaction in the presence of a phosphorus derivative of the formula IV ##STR1## where A and B are each a branched or unbranched alkyl or alkoxy having from 1 to 10 carbons, a substituted or unsubstituted aryl, cycloalkyl, aryloxy or cycloaryloxy;A can additionally be --H or --OH orA and B together are a substituted or unsubstituted tetramethylene or pentamethylene or substituted or unsubstituted phenyl-1,2-diol or 1,1'-binaphthyl-2,2'-diol.

    Abstract translation: PCT No.PCT / EP97 / 06425 Sec。 371日期1999年1月29日第 102（e）日期1999年1月29日PCT 1997年11月18日PCT公布。 出版物WO98 / 23570 日期1998年6月4日描述了一种改进的方法，用于通过在酸催化剂存在下使叔烯丙基醇和链烯基烷基醚反应来制备作为维生素和类胡萝卜素的芳香物质和中间体的γ，β-不饱和键 在升高的温度下，其包括在式IV的磷衍生物存在下进行反应，其中A和B各自为具有1至10个碳的支链或非支链烷基或烷氧基，取代或未取代的芳基，环烷基，芳氧基 或环氧基; A可另外为-H或-OH或A和B一起为取代或未取代的四亚甲基或五亚甲基或取代或未取代的苯基-1,2-二醇或1,1'-联萘-2,2'-二醇。

    Basic mixed oxide
    8.
    发明授权
    Basic mixed oxide 失效
    基本混合氧化物

    公开(公告)号：US4970191A

    公开(公告)日：1990-11-13

    申请号：US339745

    申请日：1989-04-18

    Applicant: Alain A. Schutz

    Inventor： Alain A. Schutz

    IPC: B01J21/10 ,  B01J21/16 ,  B01J23/00 ,  B01J37/00 ,  C01F1/00 ,  C01F7/16 ,  C07B61/00 ,  C07C5/25 ,  C07C11/08 ,  C07C45/72 ,  C07C45/74 ,  C07C47/21 ,  C07C49/20 ,  C07C49/203 ,  C07C49/603

    CPC classification number: B01J37/0045 ,  B01J21/10 ,  B01J21/16 ,  C07C45/74 ,  B01J23/007

    Abstract: Basic mixed oxides useful for base catalyzed reactions such as the aldol condensation of acetone and also useful as catalyst supports are made by mixing an acid such as nitric acid or acetic acid with a pseudob oehmite to form a gel, adding magnesium oxide or hydroxide, in a ratio of magnesium to aluminum of about 1:1 to about 10:1, agitating and heating for about 1 to 24 hours, and subsequently drying and calcining. The resulting polymorphic magnesium-aluminum oxide composition is highly effective in the aldol condensation of acetone to isophorone, and other base catalyzed reactions such as isomerization of olefins, aldol condensation of aldehydes.

    Abstract translation: 用于碱催化反应的碱性混合氧化物，例如丙酮的醛醇缩合，也可用作催化剂载体，通过将酸例如硝酸或乙酸与假勃姆石混合来形成凝胶，将氧化镁或氢氧化物加入到 镁与铝的比例为约1:1至约10:1，搅拌加热约1-24小时，随后干燥和煅烧。 所得到的多晶型镁 - 铝氧化物组合物在丙酮与异佛尔酮的醛醇缩合和其它碱催化反应如烯烃异构化，醛醛醛缩合中是非常有效的。

    Process for the preparation of .delta.-ethylenic carbonyl compounds
    9.
    发明授权
    Process for the preparation of .delta.-ethylenic carbonyl compounds 失效
    制备δ-亚乙基羰基化合物的方法

    公开(公告)号：US4510330A

    公开(公告)日：1985-04-09

    申请号：US390700

    申请日：1982-06-21

    Applicant: Norbert Bluthe ,  Jacques Gore ,  Max Malacria

    Inventor： Norbert Bluthe ,  Jacques Gore ,  Max Malacria

    IPC: B01J31/00 ,  B01J31/22 ,  C07B61/00 ,  C07C45/00 ,  C07C45/51 ,  C07C49/20 ,  C07C49/203 ,  C07C49/587 ,  C07C67/00

    CPC classification number: C07C45/512

    Abstract: Process for the preparation of .delta.-ethylenic carbonyl compounds of the formula: ##STR1## by the oxy-Cope rearrangement of a diethylenic alcohol of the formula: ##STR2## in which the transformation is carried out in the presence of a catalytic amount of a divalent palladium compound.In the depicted formulae R.sub.1, R.sub.4 and R.sub.6 each represent a hydrogen atom or a hydrocarbon radical, R.sub.2 represents a hydrogen atom and R.sub.3 and R.sub.5 each represent a hydrocarbon radical, or R.sub.3 and R.sub.4 together represent an alkylene radical (--CH.sub.2 --).sub.n (wherein n is an integer from 3 to 20 inclusive) in which one or more carbon atoms can optionally carry as substituent(s) one or more alkyl radicals containing 1 to 4 carbon atoms.The carbonyl products are useful as starting materials for the preparation of compounds intended for use in pharmacy, in agriculture or perfumery.

    Abstract translation: 通过下式的二烯醇的氧基 - Cope重排制备下式的δ-亚乙基羰基化合物的方法：＆lt; IMAGE＆gt;其中转化在催化量的 二价钯化合物。 在所示的式中，R 1和R 4各自表示氢原子或烃基，R 2表示氢原子，R 3和R 5各自表示烃基，或者R 3和R 4一起表示亚烷基（-CH 2 - ）n（ 其中n为3〜20的整数，其中一个或多个碳原子可以任选地携带一个或多个含有1至4个碳原子的烷基作为取代基。 羰基产物可用作制备用于制药，农业或香料中的化合物的起始原料。

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