公开(公告)号：US20240216328A1

公开(公告)日：2024-07-04

申请号：US18490008

申请日：2023-10-19

申请人： HOWARD UNIVERSITY

发明人： Simeon Kolawole ADESINA

IPC分类号： A61K31/366 ,  A61K9/51 ,  A61K31/337 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20

CPC分类号： A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00

摘要： Disclosed are bruceolides for the treatment of cancer, and oilier diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.

公开(公告)号：US11826344B2

公开(公告)日：2023-11-28

申请号：US15775986

申请日：2016-11-18

申请人： HOWARD UNIVERSITY

发明人： Simeon Kolawole Adesina

IPC分类号： A61K31/366 ,  A61K31/337 ,  C07D493/20 ,  A61K47/64 ,  A61P35/00 ,  A61K38/00 ,  A61K9/51

CPC分类号： A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00 ,  A61K31/337 ,  A61K2300/00 ,  A61K31/366 ,  A61K2300/00

摘要： Disclosed are bruceolides for the treatment of cancer, and other diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.

公开(公告)号：US20180230163A1

公开(公告)日：2018-08-16

申请号：US15753160

申请日：2016-08-15

申请人： Channel Therapeutics, Inc.

发明人： Sireesh Appajosyula ,  Kandalam V. Ramanujachary ,  Subash C. Jonnalagadda

IPC分类号： C07D493/20 ,  A61P35/00

CPC分类号： C07D493/20 ,  A61K31/35 ,  A61K31/4409 ,  A61K31/496 ,  A61K45/06 ,  A61P35/00

摘要： The invention relates to salinomycin derivatives such as compounds having the structure of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a therapeutically effective amount of compounds of formula (I), and the use of compounds of formula (I) for treating or inhibiting progression of cancer. The cancer is selected from the group consisting of breast cancer, pancreatic cancer, and prostate cancer.

公开(公告)号：US20170247323A1

公开(公告)日：2017-08-31

申请号：US15443575

申请日：2017-02-27

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Tatsuro MASUYAMA ,  Natsuki OKADA ,  Koji ICHIKAWA

IPC分类号： C07C381/12 ,  C07D493/20 ,  C07D327/06 ,  C08F20/18 ,  C08F20/28 ,  C08F20/24 ,  G03F7/004 ,  G03F7/038 ,  G03F7/039 ,  G03F7/16 ,  G03F7/09 ,  G03F7/20 ,  G03F7/38 ,  G03F7/32 ,  C07D493/10

CPC分类号： C07C381/12 ,  C07D327/06 ,  C07D493/10 ,  C07D493/20 ,  C07D495/10 ,  C07D495/20 ,  C08F20/18 ,  C08F20/24 ,  C08F20/28 ,  C08F2800/10 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/038 ,  G03F7/039 ,  G03F7/0397 ,  G03F7/091 ,  G03F7/162 ,  G03F7/168 ,  G03F7/2006 ,  G03F7/325 ,  G03F7/327 ,  G03F7/38 ,  H01L21/0274 ,  H01L21/0275

摘要： A salt having a group represented by the formula (aa): wherein Xa and Xb independently each represent an oxygen atom or a sulfur atom, the ring W represents a C3-C36 heterocyclic ring which has an ester bond or a thioester bond, said heterocyclic ring optionally further having an oxygen atom, a sulfur atom, a carbonyl group or a sulfonyl group each by which a methylene group has been replaced, and said heterocycilic ring optionally having a hydroxyl group, a cyano group, a carboxyl group, a C1-C12 alkyl group, a C1-C12 alkoxy group, a C2-C13 alkoxycarbonyl group, a C2-C13 acyl group, a C2-C13 acyloxy group, a C3-C12 alicyclic hydrocarbon group, a C6-C10 aromatic hydrocarbon group or any combination of these groups each by which a hydrogen atom has been replaced, and * represents a binding position.

公开(公告)号：US20170217992A1

公开(公告)日：2017-08-03

申请号：US15501260

申请日：2015-08-07

申请人： Rohm and Haas Electronic Materials Korea Ltd.

发明人： Ji-Song Jun ,  Sang-Hee Cho ,  Kyoung-Jin Park

IPC分类号： C07D519/00 ,  C07D495/20 ,  C07D493/10 ,  C07D493/22 ,  C07D493/20 ,  C07D495/22 ,  C07D495/10

CPC分类号： C07D519/00 ,  C07D209/86 ,  C07D405/04 ,  C07D405/14 ,  C07D491/10 ,  C07D491/20 ,  C07D493/10 ,  C07D493/20 ,  C07D493/22 ,  C07D495/10 ,  C07D495/20 ,  C07D495/22 ,  C09K11/06 ,  H01L51/0067 ,  H01L51/0072 ,  H01L51/5096

摘要： The present invention relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By using the organic electroluminescent compound of the present invention, it is possible to produce an organic electroluminescent device having low driving voltage and excellent luminous efficiency such as current efficiency and power efficiency, emitting color of high purity, and having improved lifespan.

公开(公告)号：US20170044180A1

公开(公告)日：2017-02-16

申请号：US15333079

申请日：2016-10-24

申请人： National Institute of Biological Sciences, Beijing

发明人： Xiaoguang Lei ,  Sudan He ,  Chao Li ,  Ting Dong

IPC分类号： C07D493/10 ,  A61K31/343 ,  A61K31/496 ,  C07D493/20 ,  A61K31/357 ,  A61K31/4178 ,  A61K45/06 ,  A61K31/4545

CPC分类号： C07D493/10 ,  A61K31/343 ,  A61K31/357 ,  A61K31/4178 ,  A61K31/4545 ,  A61K31/496 ,  A61K45/06 ,  C07D307/93 ,  C07D493/20

摘要： The invention provides novel compounds and compositions for inhibiting IKKα/β, including treating disorders associated with IKKα/β activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure:

摘要翻译： 本发明提供用于抑制IKKα/β的新型化合物和组合物，包括用上述结构化合物治疗与IKKα/β活性相关的疾病，包括癌症，自身免疫性和炎症性疾病。

公开(公告)号：US09504669B2

公开(公告)日：2016-11-29

申请号：US14818455

申请日：2015-08-05

申请人： PFIZER INC.

发明人： Chakrapani Subramanyam ,  Frank Erich Koehn ,  Kenneth John Dirico ,  Alessandra S. Eustaquio ,  Michael Eric Green ,  Haiyin He ,  Min He ,  Christopher John O'Donnell ,  Sujiet Puthenveetil ,  Anokha Ratnayake ,  Jesse Alexander Teske ,  Hui Yu Yang

IPC分类号： A61K38/00 ,  A61K31/351 ,  C07D309/10 ,  C07D405/12 ,  C07D493/20 ,  A61K45/06 ,  A61K47/48 ,  C07D309/14 ,  C07D405/14 ,  C07D493/10 ,  A61K31/397 ,  A61K31/453 ,  A61K31/496 ,  A61K31/501

CPC分类号： A61K47/6855 ,  A61K31/35 ,  A61K31/351 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/496 ,  A61K31/501 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869 ,  A61K47/6889 ,  C07D309/10 ,  C07D309/14 ,  C07D405/12 ,  C07D405/14 ,  C07D493/10 ,  C07D493/20

摘要： The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

公开(公告)号：US09169291B2

公开(公告)日：2015-10-27

申请号：US13027112

申请日：2011-02-14

申请人： Tomikazu Sasaki ,  Henry Chiu-Yuen Lai ,  Narendra Pal Singh ,  Steve J. Oh

发明人： Tomikazu Sasaki ,  Henry Chiu-Yuen Lai ,  Narendra Pal Singh ,  Steve J. Oh

IPC分类号： C07K7/08 ,  C07K7/02 ,  A61K38/04 ,  A61K47/48 ,  B82Y5/00 ,  C07D493/18 ,  C07D493/20 ,  C07D519/00 ,  C07K7/06 ,  A61K38/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K47/64 ,  A61K47/66 ,  B82Y5/00 ,  C07D493/18 ,  C07D493/20 ,  C07D519/00 ,  C07K7/06 ,  Y02A50/411

摘要： The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.

摘要翻译： 本发明涉及内过氧化物与结合于转铁蛋白或乳铁蛋白受体上的分子腔的小肽和有机化合物之间的共价缀合物，以及包含这些缀合物的组合物用于治疗癌症，过度增殖性疾病，炎性疾病和感染的共价缀合物。

公开(公告)号：US09169277B2

公开(公告)日：2015-10-27

申请号：US14174301

申请日：2014-02-06

申请人： Massachusetts Institute of Technology

发明人： Timothy F. Jamison ,  Yutaka Ikeuchi

IPC分类号： C07D317/00 ,  C07F7/18 ,  C07D317/20 ,  C07D317/26 ,  C07D493/20

CPC分类号： C07F7/1804 ,  C07D317/20 ,  C07D317/26 ,  C07D493/20

摘要： The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.

摘要翻译： 本发明一般涉及合成催化剂的方法，包括环氧化催化剂以及相关化合物和催化剂组合物。 本文描述的实施方案可以提供大量提供催化剂（例如环氧化催化剂）和使用简化方法的有效方法。

公开(公告)号：USRE45324E1

公开(公告)日：2015-01-06

申请号：US13495909

申请日：2012-06-13

申请人： Brian Austad ,  Charles E. Chase ,  Francis G. Fang

发明人： Brian Austad ,  Charles E. Chase ,  Francis G. Fang

IPC分类号： A61K31/341 ,  C07D307/12

CPC分类号： C07F7/1804 ,  A61K31/341 ,  C07C33/423 ,  C07D307/12 ,  C07D307/28 ,  C07D307/33 ,  C07D317/72 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10 ,  C07D493/18 ,  C07D493/20 ,  C07D493/22 ,  C07F7/188 ,  C07H15/26 ,  Y02P20/55

摘要： The present invention provides macrocyclic compounds, synthesis of the same and intermediates thereto. Such compounds, and compositions thereof, are useful for treating or preventing proliferative disorders Formula (F-4).

摘要翻译： 本发明提供大环化合物，其合成及其中间体。 这些化合物及其组合物可用于治疗或预防增殖性疾病（F-4）。