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公开(公告)号:US12071563B2
公开(公告)日:2024-08-27
申请号:US17038304
申请日:2020-09-30
申请人: AGC Inc.
发明人: Taiki Hoshino , Kiyotaka Takao , Kazue Toda , Kenji Ishizeki , Akira Isobe
IPC分类号: C09D201/04 , B32B33/00 , C07F7/18 , C08F259/08 , C08G65/00 , C08G65/329 , C08G65/336 , C09D171/00 , C09D201/10
CPC分类号: C09D201/04 , B32B33/00 , C07F7/1804 , C08F259/08 , C08G65/007 , C08G65/329 , C08G65/336 , C09D171/00 , C09D201/10 , B32B2307/7265 , B32B2307/746
摘要: To provide a fluorinated ether compound, a fluorinated ether composition and a coating liquid that are able to form a surface layer which is excellent in water/oil repellency, abrasion resistance, fingerprint stain removability, lubricity and outer appearance, and an article having such a surface layer. A fluorinated ether compound represented by A1-O—(Rf1O)m1Q1-[C(O)N(R1)]p1—R11—C[—R12—SiR13n1X13-n1]3, wherein A1 is a C1-20 perfluoroalkyl group; Rf1 is a fluoroalkylene group having no branched structure; m1 is an integer from 2 to 210; Q1 is a single bond or a fluoroalkylene group having no branched structure; R1 is a hydrogen atom, etc.; p1 is 0 or 1; R11 is a single bond, an alkylene group, etc.; R12 is an alkylene group, etc.; R13 is a monovalent hydrocarbon group, etc.; X1 is a hydrolyzable group; and n1 is an integer of from 0 to 2.
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公开(公告)号:US11813241B2
公开(公告)日:2023-11-14
申请号:US16125341
申请日:2018-09-07
申请人: Nektar Therapeutics
IPC分类号: A61K31/337 , A61K47/60 , C08G65/329 , C08G65/333 , C07D305/14
CPC分类号: A61K31/337 , A61K47/60 , C07D305/14 , C08G65/329 , C08G65/33337 , C08L2203/02
摘要: Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.
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公开(公告)号:US11643572B2
公开(公告)日:2023-05-09
申请号:US17118665
申请日:2020-12-11
申请人: AGC Inc.
发明人: Taiki Hoshino , Kiyotaka Takao , Kazue Toda , Kenji Ishizeki , Akira Isobe
IPC分类号: C09D201/04 , C08G65/336 , C08G65/00 , C08G65/329 , C07F7/18 , C09D171/00 , B32B33/00 , C08F259/08 , C09D201/10
CPC分类号: C09D201/04 , B32B33/00 , C07F7/1804 , C08F259/08 , C08G65/007 , C08G65/329 , C08G65/336 , C09D171/00 , C09D201/10 , B32B2307/7265 , B32B2307/746
摘要: To provide a fluorinated ether compound, a fluorinated ether composition and a coating liquid that are able to form a surface layer which is excellent in water/oil repellency, abrasion resistance, fingerprint stain removability, lubricity and outer appearance, and an article having such a surface layer. A fluorinated ether compound represented by A1-O—(Rf1O)m1-Q1-[C(O)N(R1)]p1—R11—C[—R12—SiR13n1X13-n1]3, wherein A1 is a C1-20 perfluoroalkyl group; Rf1 is a fluoroalkylene group having no branched structure; m1 is an integer from 2 to 210; Q1 is a single bond or a fluoroalkylene group having no branched structure; R1 is a hydrogen atom, etc.; p1 is 0 or 1; R11 is a single bond, an alkylene group, etc.; R12 is an alkylene group, etc.; R13 is a monovalent hydrocarbon group, etc.; X1 is a hydrolyzable group; and n1 is an integer of from 0 to 2.
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公开(公告)号:US20220177647A1
公开(公告)日:2022-06-09
申请号:US17679282
申请日:2022-02-24
IPC分类号: C08G65/333 , C08G65/331 , C08G65/329 , C08G65/336
摘要: A fluoropolyether group-containing compound of formula (1a) or formula (1b): wherein RF1, RF2, R1 and R2 are as defined herein.
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公开(公告)号:US20220168448A1
公开(公告)日:2022-06-02
申请号:US17366846
申请日:2021-07-02
IPC分类号: A61K48/00 , A61K9/127 , A61K9/51 , C08G65/329 , C08G65/334 , C08G75/08 , C08L71/02 , C08G83/00 , A61K9/107 , A61K31/337 , A61K31/573 , A61K31/713 , A61K47/10 , A61K47/22 , A61K47/34 , C07K16/00 , C12N15/113 , C12N15/115
摘要: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix.
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6.
公开(公告)号:US20210269601A1
公开(公告)日:2021-09-02
申请号:US17189868
申请日:2021-03-02
发明人: Juntao Luo , Xu Wang , Changying Shi
摘要: Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.
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7.
公开(公告)号:US10947350B2
公开(公告)日:2021-03-16
申请号:US15759665
申请日:2016-09-12
发明人: Juntao Luo , Xu Wang , Changying Shi
摘要: Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.
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公开(公告)号:US10941248B2
公开(公告)日:2021-03-09
申请号:US16165903
申请日:2018-10-19
申请人: Nektar Therapeutics
IPC分类号: C08G65/00 , C08G65/333 , C08G65/322 , C08G65/329 , A61K47/60 , C08G65/323 , C08G65/48 , B01D15/36 , C08G65/30 , C08G65/332
摘要: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
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公开(公告)号:US20210024693A1
公开(公告)日:2021-01-28
申请号:US17062457
申请日:2020-10-02
申请人: Nektar Therapeutics
发明人: Antoni Kozlowski , Samuel P. McManus , Sachin Tipnis , Greg Lavaty , David Swallow , John R. Handley , Anthony G. Schaefer
IPC分类号: C08G65/331 , C08G65/329 , C08G65/333 , A61K47/60 , C07C51/41 , C07C53/18 , C08G65/48 , C07D491/22 , A61K31/4745
摘要: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
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公开(公告)号:US10862164B2
公开(公告)日:2020-12-08
申请号:US15624226
申请日:2017-06-15
发明人: Myungjin Lee , Kihyun Kim , Taehwan Yu , Wonseok Chang
IPC分类号: H01M10/0565 , C08F222/10 , C08L33/16 , C08G65/00 , H01M4/38 , H01M4/134 , H01M10/052 , C08G65/329 , C08K5/435 , H01M10/0525 , H01M4/36
摘要: A polymer electrolyte including a polymerization product of a polymer having an unsaturated functional group at a terminal thereof and a fluoroalkylene chain, and an ion-conductive polymer having an unsaturated functional group at a terminal thereof, wherein the ion-conductive polymer having an unsaturated functional group at a terminal thereof is a polymer represented by Formula 1 or Formula 2, and the polymer having an unsaturated functional group at a terminal thereof and a fluoroalkylene chain is a compound represented by Formula 3, wherein Formulae 1 to 3 are the same as represented in the detailed description of the specification.
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