公开(公告)号：US08058210B2

公开(公告)日：2011-11-15

申请号：US12617000

申请日：2009-11-12

Applicant: Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

Inventor： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC: A01N35/06 ,  A01N31/06 ,  C07C49/15

CPC classification number: A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

Abstract translation: 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q1至Q6各自如本说明书所定义，其多个制备方法及其作为农药和除草剂的用途。

公开(公告)号：US20110092554A1

公开(公告)日：2011-04-21

申请号：US12743678

申请日：2008-11-19

Applicant: Richard Chesworth ,  Gideon Shapiro

Inventor： Richard Chesworth ,  Gideon Shapiro

IPC: A61K31/433 ,  C07D271/12 ,  A61K31/4245 ,  A61P25/28

CPC classification number: C07C59/64 ,  C07C57/62 ,  C07C59/56 ,  C07C59/72 ,  C07C59/88

Abstract: The present disclosure relates to novel 1,3,5 tri-substituted benzenes of general formula (I), (II) or (III) and the use of such compounds in the treatment of diseases associated with the deposition of -amyloid in the brain.

Abstract translation: 本公开涉及通式（I），（II）或（III）的新的1,3,5-三取代苯，以及这些化合物在治疗与脑中淀粉样蛋白沉积相关的疾病中的用途 。

公开(公告)号：US20100087320A1

公开(公告)日：2010-04-08

申请号：US12617000

申请日：2009-11-12

Applicant: Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

Inventor： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC: A01N43/78 ,  A01N43/08 ,  C07D305/12 ,  C07D307/94 ,  A01N43/12 ,  A01N43/38 ,  C07D209/54 ,  C07D279/06 ,  A01N43/58 ,  C07D487/00 ,  C07D405/04 ,  A01N43/40 ,  A01N37/02 ,  C07C69/00

CPC classification number: A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

Abstract translation: 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q1至Q6各自如本说明书所定义，其多个制备方法及其作为农药和除草剂的用途。

公开(公告)号：US20090093650A1

公开(公告)日：2009-04-09

申请号：US12247191

申请日：2008-10-07

Applicant: Peng Cheng ,  Jingyuan Ma ,  Xin Chen ,  Yan Zhu ,  Zuchun Zhao

Inventor： Peng Cheng ,  Jingyuan Ma ,  Xin Chen ,  Yan Zhu ,  Zuchun Zhao

IPC: C07B55/00 ,  C07C59/64 ,  C07C229/02

CPC classification number: C07C233/18 ,  C07B57/00 ,  C07C51/487 ,  C07C231/14 ,  C07C59/88

Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.

Abstract translation: 本发明提供用于制备下式的对映异构体富集的α-（苯氧基）苯乙酸化合物的方法和化合物：其对映异构体的混合物，其中R 1为烷基或卤代烷基，X为卤化物。

公开(公告)号：US07288676B2

公开(公告)日：2007-10-30

申请号：US11330601

申请日：2006-01-12

Applicant: Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

Inventor： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC: C07C57/72 ,  C07C57/76

CPC classification number: A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

Abstract translation: 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q 1至Q 6的基团各自如说明书中所定义，涉及多种制备方法及其用途 作为农药和除草剂。

公开(公告)号：US07105471B2

公开(公告)日：2006-09-12

申请号：US10777528

申请日：2004-02-12

Applicant: Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

Inventor： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC: C07D401/04 ,  A01N43/56

CPC classification number: A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups  in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

Abstract translation: 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q 1至Q 6的基团各自如说明书中所定义，涉及多种制备方法及其用途 作为农药和除草剂。

公开(公告)号：US06613914B2

公开(公告)日：2003-09-02

申请号：US10086583

申请日：2002-03-01

Applicant: Ahmed F. Abdel-Magid ,  Bruce D. Harris ,  Cynthia A. Maryanoff

Inventor： Ahmed F. Abdel-Magid ,  Bruce D. Harris ,  Cynthia A. Maryanoff

IPC: C07D23112

CPC classification number: C07D231/12 ,  C07C51/083 ,  C07C59/88

Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.

Abstract translation: 制备式I化合物的方法，其中取代基如说明书中所述包括使式II的酮与琥珀酸酐和醇盐碱反应形成式III化合物，其与式IV化合物反应形成 钒的化合物与醇反应以形成相应的式VI的酯，并使酯与N-甲基羟胺反应。

公开(公告)号：US06504036B1

公开(公告)日：2003-01-07

申请号：US10006115

申请日：2001-12-10

Applicant: Folker Lieb ,  Reiner Fischer ,  Thomas Bretschneider ,  Michael Ruther ,  Alan Graff ,  Udo Schneider ,  Christoph Erdelen ,  Ulrike Wachendorff-Neuman ,  Wolfram Andersch ,  Andreas Turberg

Inventor： Folker Lieb ,  Reiner Fischer ,  Thomas Bretschneider ,  Michael Ruther ,  Alan Graff ,  Udo Schneider ,  Christoph Erdelen ,  Ulrike Wachendorff-Neuman ,  Wolfram Andersch ,  Andreas Turberg

IPC: C07C20500

CPC classification number: C07D405/14 ,  C07C57/34 ,  C07C57/58 ,  C07C59/64 ,  C07C59/88 ,  C07C69/65 ,  C07C69/734 ,  C07C69/757 ,  C07C233/51 ,  C07C233/52 ,  C07C235/36 ,  C07C255/29 ,  C07C2601/14 ,  C07D207/38 ,  C07D209/96 ,  C07D231/56 ,  C07D307/94 ,  C07D309/14 ,  C07D313/04 ,  C07D333/50 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D409/14 ,  C07D417/14 ,  C07D491/10 ,  C07D493/10

Abstract: The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups in which A, B, D, G, X and Z are each as defined in the description, to a plurality of processes and intermediates for their preparation, and to their use as pesticides.

Abstract translation: 本发明涉及式（I）的新型苯基取代的环酮酮，其中Het表示A，B，D，G，X和Z中的每一个如在说明书中所定义的基团与多个过程和中间体 准备和用作农药。

公开(公告)号：US20020188136A1

公开(公告)日：2002-12-12

申请号：US10137763

申请日：2002-05-02

Inventor： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC: C07D333/34 ,  C07D307/56 ,  C07D231/50 ,  C07D207/273

CPC classification number: A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) 1 in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups 2 nullin which A, B. D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

Abstract translation: 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q1至Q6各自如本说明书所定义，其多个制备方法及其作为农药和除草剂的用途。

公开(公告)号：US06348597B2

公开(公告)日：2002-02-19

申请号：US09824788

申请日：2001-04-04

Applicant: Richard C. Krauss ,  Robert M. Strom ,  Carey L. Scortichini ,  William J. Kruper ,  Richard A. Wolf ,  Weishi W. Wu ,  Albert A. Carr ,  David A. Hay ,  Duane E. Rudisill ,  Gianbattista Panzone

Inventor： Richard C. Krauss ,  Robert M. Strom ,  Carey L. Scortichini ,  William J. Kruper ,  Richard A. Wolf ,  Weishi W. Wu ,  Albert A. Carr ,  David A. Hay ,  Duane E. Rudisill ,  Gianbattista Panzone

IPC: C07D21114

CPC classification number: C07D295/185 ,  C07C33/46 ,  C07C45/46 ,  C07C45/63 ,  C07C45/65 ,  C07C45/673 ,  C07C49/792 ,  C07C49/798 ,  C07C49/80 ,  C07C49/813 ,  C07C49/82 ,  C07C49/825 ,  C07C49/83 ,  C07C49/835 ,  C07C49/86 ,  C07C59/86 ,  C07C59/88 ,  C07C69/007 ,  C07C69/738 ,  C07C235/78 ,  C07C255/16 ,  C07C259/06 ,  C07C2601/02 ,  C07D211/22 ,  C07D401/06 ,  C07D401/10

Abstract: The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents —C(═O)— or —CH(OH)—; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Abstract translation: 本发明涉及一种新的中间体和方法，其可用于制备W代表-C（= O） - 或-CH（OH） - 的某些抗组胺型哌啶衍生物; R 1表示氢或羟基; R 2表示氢 R 1和R 2一起形成在具有R 1和R 2的碳原子之间的第二个键; n是1至5的整数; m是整数0或1; R 3是-COOH或-COO烷基，其中烷基部分具有 1至6个碳原子，并且是直链或支链的，每个A是氢或羟基; 和其药学上可接受的盐和单独的光学异构体，条件是其中R 1和R 2一起形成在具有R 1和R 2的碳原子之间或其中R 1表示羟基的第二个键，m是整数0。