公开(公告)号：US11866443B2

公开(公告)日：2024-01-09

申请号：US16614400

申请日：2018-05-09

Applicant: BASF Agro B.V.

Inventor： Klaus Ditrich ,  Michael Rack ,  Stefan Benson ,  Roland Goetz ,  Helmut Kraus

IPC: C07D493/08 ,  C07B57/00

CPC classification number: C07D493/08 ,  C07B57/00 ,  C07B2200/07

Abstract: The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.

公开(公告)号：US20230364029A1

公开(公告)日：2023-11-16

申请号：US18218575

申请日：2023-07-05

Applicant: PTC THERAPEUTICS, INC.

Inventor： Paul MOLLARD ,  Peter GIANNOUSIS ,  Shazad SUCHIT ,  Mahmoud MIRMEHRABI ,  Christopher R. CORNELL ,  Kieron E. WESSON

IPC: A61K31/122 ,  C07C215/30 ,  C07C215/08 ,  C07C235/78 ,  C07C215/28 ,  A61K31/164 ,  C07C231/12 ,  C07B57/00

CPC classification number: A61K31/122 ,  A61K31/164 ,  C07B57/00 ,  C07C215/08 ,  C07C215/28 ,  C07C215/30 ,  C07C231/12 ,  C07C235/78 ,  C07B2200/13 ,  C07C2601/16

Abstract: Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.

公开(公告)号：US20190047941A1

公开(公告)日：2019-02-14

申请号：US16078522

申请日：2017-02-25

Applicant: SRM UNIVERSITY

Inventor： Harinipriya SESHADRI ,  Samanwita PAL ,  Deepak KUMAR

IPC: C07C227/34 ,  C07C229/08 ,  C07B57/00 ,  C25B3/00 ,  C25B15/08 ,  C25B11/04

CPC classification number: C07C227/34 ,  C07B57/00 ,  C07B2200/07 ,  C07C229/08 ,  C25B3/00 ,  C25B11/041 ,  C25B15/08

Abstract: The process comprises electrolyzing the first electrolyte having 1 molar solution of lithium perchlorate and 0.01 molar solution of racemic mixture of amino acid in an electrochemical cell containing a working electrode having polycrystalline metal surface configured to adsorb L-enantiomer of amino acid using a saw-tooth current. Further, the polarity of the saw-tooth current is reversed to de-adsorb the L-enantiomer of amino acid from the working electrode into the second electrolyte re-filled in the cell. The process of the present disclosure to separate enantiomer of amino acid from a racemic mixture is simple and economical.

公开(公告)号：US10058550B2

公开(公告)日：2018-08-28

申请号：US15629567

申请日：2017-06-21

Applicant: AMGEN INC.

Inventor： Ning Chen ,  Xiaoqi Chen ,  Yinhong Chen ,  Zice Fu ,  Julie Anne Heath ,  Daniel B. Horne ,  Matthew R. Kaller ,  Aarif Yusuf Khakoo ,  David John Kopecky ,  Zhihua Ma ,  Jeffrey T. Mihalic ,  Gayathri Swaminath ,  Xiaodong Wang ,  Wen-Chen Yeh

IPC: A61K31/506 ,  A61K31/497 ,  A61K45/06

CPC classification number: C07D401/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/695 ,  A61K45/06 ,  C07B57/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/07 ,  C07C311/13 ,  C07D211/54 ,  C07D213/61 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D241/24 ,  C07D249/08 ,  C07D295/16 ,  C07D401/04 ,  C07D401/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/08

Abstract: Methods of treating heart failure include administering to a subject having heart failure an effective amount of a triazole compound that is an agonist of the APJ receptor, a pharmaceutically acceptable salt of the compound, or a mixture thereof. Compounds particularly useful in such methods are provided herein.

公开(公告)号：US20170369438A1

公开(公告)日：2017-12-28

申请号：US15699954

申请日：2017-09-08

Applicant: Daiichi Sankyo Company, Limited

Inventor： Masashi Watanabe ,  Hiroshi Nagasawa ,  Noritada Sato

IPC: C07D207/34 ,  C12P17/10 ,  C07D207/456 ,  C12P41/00 ,  C07B57/00

CPC classification number: C07D207/34 ,  C07B57/00 ,  C07D207/456 ,  C12P17/10 ,  C12P41/005

Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.

公开(公告)号：US09809790B2

公开(公告)日：2017-11-07

申请号：US15421065

申请日：2017-01-31

Applicant: THE CLOROX COMPANY

Inventor： David R. Scheuing ,  William L. Smith ,  Michael Kinsinger ,  Jared Heymann

IPC: C11D17/04 ,  A01N33/12 ,  A01N43/04 ,  C07B57/00 ,  A01N59/00 ,  A01N59/16 ,  B08B1/00 ,  C11D3/37 ,  C11D3/48 ,  A01N37/02 ,  A01N43/16 ,  A01N43/36 ,  A61L15/10 ,  A61L15/46

CPC classification number: C11D17/049 ,  A01N33/12 ,  A01N37/02 ,  A01N43/16 ,  A01N43/36 ,  A01N59/00 ,  A01N59/16 ,  A61L15/10 ,  A61L15/46 ,  B08B1/006 ,  C07B57/00 ,  C11D3/3723 ,  C11D3/3757 ,  C11D3/3776 ,  C11D3/378 ,  C11D3/48 ,  A01N25/10 ,  A01N25/22 ,  A01N25/24

Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide a cleaning benefit and surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge. Treatment means and compositions are provided that employ associative polyelectrolyte complexes formed by combining a water soluble cationic first polyelectrolyte with a water soluble second polyelectrolyte bearing groups of opposite charge to the first polyelectrolyte under suitable mixing conditions and at least one oxidant selected from the group: alkaline metal salts and/or alkaline earth metal salts of hypochlorous acid, hypochlorous acid, solubilized chlorine, any source of free chlorine, acidic sodium chlorite, active chlorine generating compound and any combinations or mixtures thereof. Also provided are means to form stable associative polyelectrolyte complexes with at least one oxidant in aqueous solutions having R values from about 0.10 to 20.

公开(公告)号：US09765025B2

公开(公告)日：2017-09-19

申请号：US15043260

申请日：2016-02-12

Applicant: Daiichi Sankyo Company, Limited

Inventor： Masashi Watanabe ,  Hiroshi Nagasawa ,  Noritada Sato

IPC: C07D207/34 ,  C07D207/456 ,  C07B57/00 ,  C12P41/00 ,  C12P17/10

CPC classification number: C07D207/34 ,  C07B57/00 ,  C07D207/456 ,  C12P17/10 ,  C12P41/005

Abstract: The present invention provides a method for producing an atropisomer of a pyrrole derivative having excellent mineralocorticoid receptor antagonistic activity, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [wherein R1 represents a C1-C4 alkyl group, and R2 represents a 2-hydroxyethyl group or a carboxymethyl group] as a production intermediate.

公开(公告)号：US09751864B2

公开(公告)日：2017-09-05

申请号：US15298434

申请日：2016-10-20

Applicant: AMGEN INC.

Inventor： Ning Chen ,  Xiaoqi Chen ,  Richard V. Connors ,  Jeffrey Deignan ,  Paul John Dransfield ,  Xiaohui Du ,  Zice Fu ,  Julie Anne Heath ,  Daniel B. Horne ,  Jonathan Houze ,  Matthew R. Kaller ,  David John Kopecky ,  Su-Jen Lai ,  Zhihua Ma ,  Lawrence R. McGee ,  Julio C. Medina ,  Jeffrey T. Mihalic ,  Nobuko Nishimura ,  Steven H. Olson ,  Vatee Pattaropong ,  Xiaodong Wang ,  Kevin Yang ,  Mikkel V. DeBenedetto ,  Robert P. Farrell ,  Simon J. Hedley ,  Ted C. Judd

IPC: C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D413/14 ,  C07D413/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  C07B57/00 ,  C07B59/00 ,  C07D211/54 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D241/12 ,  C07D241/24 ,  C07D249/08 ,  C07D405/14 ,  C07D401/12 ,  A61K31/695 ,  C07F7/08 ,  A61K31/437 ,  C07C311/13 ,  C07D213/61 ,  C07D239/34 ,  C07D241/18 ,  C07D295/16

CPC classification number: A61K31/506 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61K31/695 ,  A61K45/06 ,  C07B57/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/07 ,  C07C311/13 ,  C07D211/54 ,  C07D213/61 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D241/24 ,  C07D249/08 ,  C07D295/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/08

Abstract: Methods of preparing compounds of Formula VI, salts thereof, tautomers thereof, or salts of the tautomers include cyclizing compounds of Formula V, salts thereof, tautomers thereof, or salts of the tautomers. Compounds of Formula VI and Formula V have the following structures: where the definitions of the variables are provided herein.

公开(公告)号：US20170073351A1

公开(公告)日：2017-03-16

申请号：US15278759

申请日：2016-09-28

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Mikhail Chafeev ,  Jianmin Fu ,  Jean-Jacques Alexandre Cadieux

IPC: C07D491/20 ,  C07B57/00

CPC classification number: C07D491/20 ,  A61K31/407 ,  C07B57/00 ,  C07B2200/07 ,  C07D491/22

Abstract: This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.

Abstract translation: 或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。

公开(公告)号：US20170002304A1

公开(公告)日：2017-01-05

申请号：US15269085

申请日：2016-09-19

Applicant: THE CLOROX COMPANY

Inventor： DAVID R. SCHEUING ,  WILLIAM L. SMITH ,  MICHAEL KINSINGER ,  JARED HEYMANN

IPC: C11D17/04 ,  C11D3/37 ,  B08B1/00 ,  C11D3/48

CPC classification number: C11D17/049 ,  A01N33/12 ,  A01N37/02 ,  A01N43/16 ,  A01N43/36 ,  A01N59/00 ,  A01N59/16 ,  A61L15/10 ,  A61L15/46 ,  B08B1/006 ,  C07B57/00 ,  C11D3/3723 ,  C11D3/3757 ,  C11D3/3776 ,  C11D3/378 ,  C11D3/48 ,  A01N25/10 ,  A01N25/22 ,  A01N25/24

Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide a cleaning benefit and surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge. Treatment means and compositions are provided that employ associative polyelectrolyte complexes formed by combining a water soluble cationic first polyelectrolyte with a water soluble second polyelectrolyte bearing groups of opposite charge to the first polyelectrolyte under suitable mixing conditions and at least one oxidant selected from the group: alkaline metal salts and/or alkaline earth metal salts of hypochlorous acid, hypochlorous acid, solubilized chlorine, any source of free chlorine, acidic sodium chlorite, active chlorine generating compound and any combinations or mixtures thereof. Also provided are means to form stable associative polyelectrolyte complexes with at least one oxidant in aqueous solutions having R values from about 0.10 to 20.

Abstract translation: 本发明涉及可选地含有表面活性剂，杀生物剂和/或氧化剂的缔合聚电解质复合物（PEC）的含水组合物，其可以为处理物品提供清洁效果和表面保护，包括减少污染趋势，降低清洁力和改善防污性 ，以及为处理的表面提供抑菌性能，从而获得对水的耐受性，环境暴露和微生物挑战。 提供了处理装置和组合物，其使用通过在适合的混合条件下将水溶性阳离子第一聚电解质与带有相反电荷的水溶性第二聚电解质带入基团的第一聚电解质组合形成的缔合聚电解质复合物和至少一种选自以下的氧化剂：碱 次氯酸，次氯酸，溶解氯，任何游离氯源，酸性亚氯酸钠，活性氯产生化合物的金属盐和/或碱土金属盐及其任何组合或混合物。 还提供了在水溶液中形成具有约0.10至20的R值的至少一种氧化剂的稳定的缔合聚电解质络合物的方法。