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    Nanoparticles
    1.
    发明授权
    Nanoparticles 有权

    公开(公告)号：US11786468B2

    公开(公告)日：2023-10-17

    申请号：US15580189

    申请日：2016-06-08

    申请人： KING'S COLLEGE LONDON

    发明人： Maria Thanou ,  Michael James Lee Wright ,  Miguel Centelles ,  Andrew David Miller ,  Wladyslaw Gedroyc

    IPC分类号： A61K9/127 ,  A61K49/08 ,  A61K31/4745 ,  A61K31/704 ,  A61K49/10 ,  A61K49/18 ,  A61K41/00

    CPC分类号： A61K9/1272 ,  A61K31/4745 ,  A61K31/704 ,  A61K41/0052 ,  A61K49/085 ,  A61K49/106 ,  A61K49/1812 ,  A61K49/1839

    摘要： The invention provides a (drug-containing) lipid nanoparticle with:



    (i) at least one phospholipid;
    (ii) at least one lysolipid; and
    (iii) at least one phospholipid comprising a hydrophilic polymer; and
    (iv) at least one structural lipid of formula (I) which has the following general structure:










    wherein R and R′ are long hydrocarbyl hydrophobic chains, Y is a linker element, and PHG is a polar head group described as large according to its van der Waals radius, and which is different from the phospholipid (i).




    The lipid nanoparticle can release a drug (or API) from within the lipid nanoparticle as a result of focused ultrasound (FUS) applied continuously, at least twice, to a desired part of the body to induce hyperthermia (an increase in temperature). FUS is applied after the lipid nanoparticle containing the drug has been administered to the live subject, and causes controlled release of the drug at the desired site of the body. Ultrasound is then halted, and the site of interest allowed to cool. Ultrasound is then applied again. Lipid nanoparticles can be labelled (for MRI, NIRF imaging), enabling real time monitoring of the drug in the human body. Imaging information can be used to direct and guide the nature of the FUS applied to the site of interest.

    Lipid-Based Drug Carriers for Rapid Penetration Through Mucus Linings
    9.
    发明申请
    Lipid-Based Drug Carriers for Rapid Penetration Through Mucus Linings 有权
    基于脂质的药物载体通过粘膜衬里快速穿透

    公开(公告)号：US20150086484A1

    公开(公告)日：2015-03-26

    申请号：US14397828

    申请日：2013-05-06

    申请人： The Johns Hopkins University

    发明人： Justin Hanes ,  Kannie Wai Yan Chan ,  Michael T. McMahon ,  Ming Yang ,  Tao Yu

    IPC分类号： A61K47/48 ,  A61K49/18 ,  A61K31/704

    CPC分类号： A61K47/6911 ,  A61K9/1271 ,  A61K31/704 ,  A61K49/1812

    摘要： Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.

    摘要翻译： 粘膜渗透性脂质体纳米颗粒及其制备和使用方法在此描述。 纳米颗粒包含一种或多种脂质，一种或多种PEG-缀合的脂质，以及任选的一种或多种物理和/或化学稳定颗粒的另外的材料。 纳米颗粒的平均直径为约100nm至约300nm，优选为约100nm至约250nm，更优选为约100nm至约200nm。 颗粒在粘液中是可移动的。 脂质体可以进一步含有一种或多种待递送至粘膜表面的治疗，预防和/或诊断剂，例如CV道，结肠，鼻，肺和/或眼睛。 脂质体可以进一步含有一种或多种CEST试剂以允许在活的动物中实时成像颗粒。 颗粒还可以进一步含有成像剂，例如荧光标记物。