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    Screening method
    3.
    发明授权
    Screening method 有权

    公开(公告)号：US12084709B2

    公开(公告)日：2024-09-10

    申请号：US18170196

    申请日：2023-02-16

    Applicant: Mars, Incorporated

    Inventor： Taichi Inui ,  Richard Mark Haydock

    IPC: C12Q1/527 ,  C12Q1/02 ,  C12Q1/18 ,  G01N21/64

    CPC classification number: C12Q1/527 ,  C12Q1/025 ,  C12Q1/18 ,  G01N21/64 ,  G01N2469/00 ,  G01N2496/00

    Abstract: A method for screening substances for their ability to reduce malodours from emanations from an animal, said method comprising determining the effect of said substances on the C-S lyase activity of bacteria that emit volatile sulphuric compounds (VSCs), by contacting a test substance with a sample comprising said bacteria or a supernatant obtainable from a culture of said bacteria in the presence of a substrate for a C-S lyase, detecting the levels of thiol production from said bacteria, and comparing the results with those obtained from similar bacteria in the absence of said substance.

    Hydroporphyrin beads with narrow fluorescence emissions
    8.
    发明授权
    Hydroporphyrin beads with narrow fluorescence emissions 有权

    公开(公告)号：US11999885B2

    公开(公告)日：2024-06-04

    申请号：US16308285

    申请日：2017-06-12

    Applicant: NIRvana Sciences

    Inventor： James Bruce Pitner ,  Rosemary B. Evans-Storms ,  Duane A. Olsen

    IPC: C09K11/06 ,  C09K11/02 ,  G01N21/64

    CPC classification number: C09K11/06 ,  C09K11/02 ,  G01N21/64 ,  C09K2211/186

    Abstract: Provided are fluorescent microparticles and/or nanoparticles that have a polymeric matrix and at least one porphyrinic macrocycle associated therewith. The porphyrinic macrocycles associated with the presently disclosed fluorescent microparticles and/or nanoparticles are in some embodiments selected from the group consisting of porphyrins (including 17,18-didehydrophorbines), chlorins (including phorbines), bacteriochlorins (including bacteriophorbines), and isobacteriochlorins (including isobacteriochlorins containing a fused “E” ring). In some embodiments, the porphyrinic macrocycles have structures selected from Formulas I and H. Also provided are populations made up of a plurality of distinct fluorescent microparticles and/or nanoparticles, methods of making and using the same, sets of separately detectable fluorescent microparticles and/or nanoparticles and methods for preparing and using the same, porphyrinic macrocycle-containing dyads conjugated to particles and methods for using the same to calibrate multi-laser flow cytometers, align and/or calibrate confocal fluorescence microscopes, and/or differentially labeling cells and/or other biomolecules, and biomolecules such as antibodies, fragments, and derivatives thereof covalently conjugated to the presently disclosed fluorescent microparticles and/or nanoparticles and/or to the presently disclosed porphyrinic macrocycle-containing dyads.

    IMPLANTABLE APPARATUS FOR SENSING BIOLOGIC SIGNALS
    10.
    发明公开
    IMPLANTABLE APPARATUS FOR SENSING BIOLOGIC SIGNALS 审中-公开

    公开(公告)号：US20240130684A1

    公开(公告)日：2024-04-25

    申请号：US18399914

    申请日：2023-12-29

    Applicant: EFFERENT LABS, INC.

    Inventor： Marek Kowarz ,  Spencer Rosero

    IPC: A61B5/00 ,  A61B10/02 ,  G01N21/64

    CPC classification number: A61B5/6865 ,  A61B10/02 ,  G01N21/64 ,  A61B2560/0219 ,  A61B2562/0233 ,  G01N2201/062 ,  G01N2201/0693

    Abstract: An implantable apparatus for physiological measurement in a host organism has an implantable sample chamber having a measurement port and live cells that are treated to fluoresce in response to light having an excitation wavelength. An optical sensor housing implanted within the host organism has a window to convey excitation light output and receive fluorescent light; a coupling that couples the measurement port of the sample chamber to the window; an optical chamber partitioned into an excitation sub-chamber and a detection sub-chamber, wherein both sub-chambers are in optical communication with the window; an excitation source energizable to direct excitation light through the excitation sub-chamber and to the window; and a detector in the path of fluorescent light received from the live cells. A signal processing apparatus is energizable to acquire and process a detector signal and to transmit a processed signal that is indicative of fluorescent light energy.

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