公开(公告)号：US12109046B2

公开(公告)日：2024-10-08

申请号：US17336419

申请日：2021-06-02

Applicant: YuScan USA, LLC

Inventor： Nai-Teng Yu ,  Rong-Chun Yu

IPC: A61B5/00 ,  A61B3/117 ,  A61B3/18 ,  G01J1/60 ,  G01N21/64 ,  G06T7/00

CPC classification number: A61B5/6821 ,  A61B3/1173 ,  A61B3/18 ,  G01J1/60 ,  G01N2021/6471 ,  G06T7/00

Abstract: A method is provided that includes discriminating an autofluorescence (AF) response of a lens tissue of an eye due to a current level of 2-(2-furoyl)-4(5)-furanyl-1H-imidazole (FFI) in the lens tissue by interrogating a lens tissue of an eye along a visual axis of the eye by activating an illuminator for a select time to produce interrogating irradiation having a peak wavelength of 425 nm to 460 nm, the illuminator comprising at least one light source and a focal lens positioned with respect to the light source. The method also includes obtaining at least one image of the autofluorescence response of the lens tissue from a detector, the detector including a digital camera unit, analyzing the at least one image to determine a total autofluorescence index of the lens tissue, and determining a current level of FFI in the lens tissue based, at least in part, on the total autofluorescence index.

公开(公告)号：US12085508B2

公开(公告)日：2024-09-10

申请号：US17749162

申请日：2022-05-20

Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY

Inventor： Xiangjun Gong ,  Wenzhang Tian ,  Yongping Zeng ,  Lianjun Bao ,  Guangzhao Zhang ,  Xiao Liang ,  Xiawen Qiu

IPC: G01N21/64 ,  G01N13/00 ,  G01N33/18

CPC classification number: G01N21/645 ,  G01N13/00 ,  G01N33/1826 ,  G01N2013/003 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2021/6484

Abstract: Provided are a synchronous fluorescence detector for observing the interface concentration of fluorescent pollutants and application method. The detector comprises a first electric displacement platform, a quartz cuvette, an excitation light path, a collection light path and a second electric displacement platform. The application method comprises the following steps: first exciting fluorescent pollutants by utilizing UV light with specific wavelengths to emit fluorescent light; then collecting fluorescence signals emitted by the excited fluorescent pollutants to the greatest extent by utilizing an UV anti-reflection convex lens combination; and finally, processing the fluorescent signals acquired by a photomultiplier by utilizing a difference method to determine a precise light intensity of a thin layer which is moved at a specific spacing by utilizing the electric displacement platforms so as to determine fugacity distribution of the fluorescent pollutants in the microlayer near an interface.

公开(公告)号：US20240295499A1

公开(公告)日：2024-09-05

申请号：US18662295

申请日：2024-05-13

Applicant: Life Technologies Corporation

Inventor： Kevin Maher ,  David Fortescue ,  Soo Yong Lau ,  Jacob K. Freudenthal ,  Woon Liang Terence SOH ,  Mingsong Chen ,  Ming Shen ,  Kuan Moon BOO

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

公开(公告)号：US12013340B2

公开(公告)日：2024-06-18

申请号：US17632429

申请日：2019-11-06

Applicant: Uster Technologies AG

Inventor： Peyman Dehkordi ,  Kent A. Rinehart ,  David Dickson McAlister, III

IPC: G01N21/64 ,  G01N21/17 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/47 ,  G01N21/55 ,  G01N33/36

CPC classification number: G01N21/6456 ,  G01N21/256 ,  G01N21/276 ,  G01N21/31 ,  G01N21/55 ,  G01N33/367 ,  G01N2021/174 ,  G01N2021/178 ,  G01N2021/3155 ,  G01N2021/4766 ,  G01N2021/6423 ,  G01N2021/6471

Abstract: An apparatus (100) for optically characterizing a textile sample (106) comprises a presentation subsystem (102) comprising a viewing window (108). A radiation subsystem (114) comprises a radiation source (120) for directing a first, ultraviolet radiation (122) and a second, visible radiation (123) toward the sample (106), and causing the sample (106) to produce a fluorescent radiation (124) and a reflected radiation (125). A sensing subsystem (126) comprises an imager (130) for capturing the fluorescent radiation (124) and the reflected radiation (125) in an array of pixels (408). A control subsystem (132) comprises a processor (136) for controlling the presentation subsystem (102), the radiation subsystem (114), and the sensing subsystem (126), and for creating a fluorescent and reflected radiation image (400) containing both spectral information and spatial information in regard to the fluorescent radiation (124) and the reflected radiation (125).

公开(公告)号：US20240192130A1

公开(公告)日：2024-06-13

申请号：US18222893

申请日：2023-07-17

Applicant: Yokogawa Electric Corporation

Inventor： Anatoliy A. Kosterev

IPC: G01N21/31 ,  G01K11/00 ,  G01N21/64

CPC classification number: G01N21/3103 ,  G01K11/00 ,  G01N21/645 ,  G01N2021/6471 ,  G01N2201/068

Abstract: Methods and apparatus for analyzing optical measurements to determine whether a liquid includes dissolved oxygen, to determine a predicted concentration of the dissolved oxygen in the liquid, and/or to determine additional or alternative feature(s) related to dissolved oxygen in the liquid. An optical source can be controlled to emit optical radiation into a container that contains the liquid. The optical source can be located outside of the container, and the optical radiation includes (e.g., is restricted to) radiation that conforms to a dissolved oxygen absorption band. The optical radiation can be pulsed or can be periodically intensity modulated. A photodetector, located outside of the container but in optical communication with the interior of the container, can generate the optical measurements used in the analysis.

公开(公告)号：US11994518B2

公开(公告)日：2024-05-28

申请号：US17073248

申请日：2020-10-16

Applicant: C2Sense, Inc.

Inventor： Timothy Manning Swager ,  Jason R. Cox ,  Robert Deans

IPC: G01N21/76 ,  C09K11/06 ,  G01J3/28 ,  G01J5/02 ,  G01N21/00 ,  G01N21/25 ,  G01N21/63 ,  G01N21/64 ,  G01N33/543 ,  G01N33/569 ,  G01N33/58 ,  G06K19/14 ,  G06V10/00 ,  G06V10/141 ,  G06V10/143 ,  G06V20/80 ,  G06V40/13 ,  H04N5/33 ,  H04N25/53 ,  H04N25/76 ,  H10K50/11 ,  A61B5/00 ,  A61B5/117 ,  G01J5/00 ,  G01N21/21 ,  G01N21/75 ,  H10K101/10

CPC classification number: G01N33/54388 ,  C09K11/06 ,  G01J3/2803 ,  G01J5/02 ,  G01N21/00 ,  G01N21/251 ,  G01N21/63 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/76 ,  G01N33/54386 ,  G01N33/56983 ,  G01N33/582 ,  G06K19/14 ,  G06V10/00 ,  G06V10/141 ,  G06V10/143 ,  G06V20/80 ,  G06V40/1318 ,  H04N5/33 ,  H04N25/53 ,  H04N25/76 ,  H10K50/11 ,  A61B5/0077 ,  A61B5/117 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1092 ,  C09K2211/182 ,  G01J2005/0077 ,  G01N21/21 ,  G01N2021/6413 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/757 ,  G01N2201/062 ,  G01N2333/165 ,  H10K2101/10

Abstract: Embodiments described herein generally relate to: sensing and/or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and/or to emissive species, such as those excitable by white light, and related systems and methods.

公开(公告)号：US20240159677A1

公开(公告)日：2024-05-16

申请号：US18388470

申请日：2023-11-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kevin MAHER ,  Mingsong CHEN ,  Jacob K. FREUDENTHAL ,  Kuan Moon BOO ,  Soo Yong LAU ,  David FORTESCUE ,  Ming SHEN ,  Woon Liang Terence SOH

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/062

Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

公开(公告)号：US11953464B2

公开(公告)日：2024-04-09

申请号：US17831424

申请日：2022-06-02

Applicant: ILLUMINA, INC.

Inventor： Dietrich Dehlinger ,  Ali Agah ,  Tracy Helen Fung ,  Emrah Kostem

IPC: G01N27/414 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/64 ,  G01N21/76 ,  G06F18/24 ,  G06V10/75 ,  G16B30/00

CPC classification number: G01N27/4145 ,  B01L3/502715 ,  C12Q1/6874 ,  G01N21/6454 ,  G06F18/24 ,  G06V10/751 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0663 ,  B01L2300/0893 ,  C12Q1/6869 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N21/76 ,  G01N21/763 ,  G01N2223/40 ,  G01N2223/413 ,  G05B2219/37563 ,  G16B30/00

Abstract: A device for base calling is provided. The device includes a receptacle configured to hold a biosensor having a sample surface holding a plurality of clusters during a sequence of sampling events, an array of sensors sensing information from clusters disposed in corresponding pixel areas of the sample surface during the sampling events and generate sequences of pixel signals and a communication port configured to output the sequences of pixel signals. The device also includes a signal processor coupled to the communication port and configured to receive and process at least one pixel signal in the sequences of pixel signals that mixes light gathered from at least two clusters in a corresponding pixel area, and to base call each of the at least two clusters using the at least one pixel signal.

公开(公告)号：US11891671B1

公开(公告)日：2024-02-06

申请号：US17210832

申请日：2021-03-24

Applicant: A9.com, Inc.

Inventor： Carlos Roberto Resquin

IPC: B01L3/00 ,  G01N21/64 ,  C12Q1/70

CPC classification number: C12Q1/70 ,  B01L3/5027 ,  B01L3/502753 ,  G01N21/645 ,  G01N21/6428 ,  G01N2021/6471

Abstract: Systems for testing for a target virus include an analysis device and a sample cartridge. A system for detecting a target virus includes a cartridge and an analysis device. A biological sample is inserted into the cartridge. The cartridge includes reagents and other liquids for processing the biological sample. The cartridge is inserted into the analysis device. The analysis device interacts with the cartridge to complete testing of the biological sample for the presence of the target virus.

公开(公告)号：US20230395408A1

公开(公告)日：2023-12-07

申请号：US18321432

申请日：2023-05-22

Applicant: Tokyo Electron Limited

Inventor： Ivan MALEEV ,  Yan SUN ,  Zheng YAN

IPC: H01L21/67 ,  G01N21/64

CPC classification number: H01L21/67248 ,  H01L21/67057 ,  G01N21/6489 ,  G01N2021/6471

Abstract: Aspects of the present disclosure provide a sensor for remote temperature measurement. For example, the sensor can include a light source configured to form an illumination beam, focusing optics configured to direct the illumination beam from the light source onto a semiconductor sample at an illuminated spot thereof, for exciting bandgap photoluminescence (PL) light in the semiconductor sample, collection optics configured to collect the bandgap PL light excited from the semiconductor sample, at least one optical detector configured to measure spectral intensities of the bandgap PL light in a vicinity of a semiconductor bandgap wavelength of the semiconductor sample, and transmission optics configured to transmit the bandgap PL light from the collection optics to the at least one optical detector.