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公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
发明人： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
发明人： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译： 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号：US20240295499A1
公开(公告)日：2024-09-05
申请号：US18662295
申请日：2024-05-13
发明人： Kevin Maher , David Fortescue , Soo Yong Lau , Jacob K. Freudenthal , Woon Liang Terence SOH , Mingsong Chen , Ming Shen , Kuan Moon BOO
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
摘要： An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.
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公开(公告)号：US11815460B2
公开(公告)日：2023-11-14
申请号：US17825222
申请日：2022-05-26
发明人： Kevin Maher , Mingsong Chen , Jacob K. Freudenthal , Kuan Moon Boo , Soo Yong Lau , David Fortescue , Ming Shen , Woon Liang Terence Soh
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
摘要： A method of analyzing a plurality of biological sample volumes comprises emitting, along an excitation optical path toward a sample holder holding the plurality of biological sample volumes, electromagnetic radiation from a broadband LED, wherein the broadband LED emits the electromagnetic radiation across a range of wavelengths at a total output power of at least 5 watts and at a maximum intensity at a wavelength less than 600 nanometers and at an intensity less than 30 percent of the maximum intensity at a wavelength of 650 or 670 nanometers, and receiving, by a sensor, an electromagnetic emission transmitted from the sample holder along an emission optical path.
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公开(公告)号：US09702823B2
公开(公告)日：2017-07-11
申请号：US14348878
申请日：2012-09-28
发明人： Kevin Maher , Mingsong Chen , Jacob Freudenthal , Kuan Moon Boo , Soo Yong Lau , David Fortescue , Ming Shen , Woon Liang Terence Soh
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
摘要： An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.
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公开(公告)号：US20200035329A1
公开(公告)日：2020-01-30
申请号：US16590303
申请日：2019-10-01
发明人： Gordon A. Janaway , Manjula Aliminati , Ruoyun Wu , David Fortescue , Ming Shen
IPC分类号： G16B40/00 , C12Q1/6851
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting of emission data from a planiality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data, A dPCR result is generated based on the positive amplification determinations for the plurality of samples.
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公开(公告)号：US10453557B2
公开(公告)日：2019-10-22
申请号：US14347864
申请日：2012-09-28
发明人： Gordon A. Janaway , Manjula Aliminati , Ruoyun Wu , David Fortescue , Ming Shen
IPC分类号： G16B40/00 , C12Q1/6851
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.
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公开(公告)号：US09772339B2
公开(公告)日：2017-09-26
申请号：US14348031
申请日：2012-09-28
发明人： David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng
CPC分类号： G01N35/00732 , G01N35/028 , G01N2015/0053 , G01N2035/00752 , G06T7/0012 , G06T2207/10004 , G06T2207/30004
摘要： A computer-implemented method for identifying a first object-of-interest is provided. The first object-of-interest includes two identifiers and a sample portion. The method includes imaging the first object-of-interest including the two identifiers. The imaging generates a first set of image data. The method further includes determining a position of the first object-of-interest in the field-of-view of an optical sensor and determining the two identifiers from the first set of image data. The method includes identifying the first object-of-interest based on the two identifiers.
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公开(公告)号：US20140247967A1
公开(公告)日：2014-09-04
申请号：US14348031
申请日：2012-09-28
发明人： David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng
CPC分类号： G01N35/00732 , G01N35/028 , G01N2015/0053 , G01N2035/00752 , G06T7/0012 , G06T2207/10004 , G06T2207/30004
摘要： A computer-implemented method for identifying a first object-of-interest is provided. The first object-of-interest includes two identifiers and a sample portion. The method includes imaging the first object-of-interest including the two identifiers. The imaging generates a first set of image data. The method further includes determining a position of the first object-of-interest in the field-of-view of an optical sensor and determining the two identifiers from the first set of image data. The method includes identifying the first object-of-interest based on the two identifiers.
摘要翻译： 提供了一种用于识别第一感兴趣物体的计算机实现的方法。 第一个感兴趣的对象包括两个标识符和一个样本部分。 该方法包括对第一感兴趣物体成像，包括两个标识符。 成像产生第一组图像数据。 该方法还包括确定第一感兴趣物体在光学传感器的视场中的位置，并根据第一组图像数据确定两个标识符。 该方法包括基于两个标识符识别第一感兴趣对象。
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公开(公告)号：US20140236496A1
公开(公告)日：2014-08-21
申请号：US14347864
申请日：2012-09-28
发明人： Gordon A. Janaway , Manjula Aliminati , Ruoyun Wu , David Fortescue , Ming Shen
IPC分类号： G06F19/24
CPC分类号： G16B40/00 , C12Q1/6851 , C12Q2537/165 , C12Q2563/159
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.
摘要翻译： 提供了产生数字聚合酶链反应（dPCR）结果的计算机实现的方法。 该方法包括在放大期间的第一时间，从多个样本中检测出第一组发射数据，每个采样包括多个采样区域的样本区域。 该方法还包括部分地基于第一组发射数据确定多个样本中的每个样本的正或负放大确定。 基于多个样本的正或负放大确定产生dPCR结果。
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