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公开(公告)号：US09267170B2
公开(公告)日：2016-02-23
申请号：US14348881
申请日：2012-09-28
发明人： Ronald Danehy , Gary Lim , Jacob Freudenthal
CPC分类号： C12Q1/6806 , B01L3/50851 , B01L3/50855 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2300/0819 , B01L2300/0829 , B01L2300/0858 , B01L2300/0893 , B01L2300/161 , C12M23/12 , C12M23/38
摘要： A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
摘要翻译： 用于容纳多个生物样品的壳体包含基底，基底和盖。 底物附着到基底上，并且包括被配置成接收一个或多个生物样品的多个反应区域。 盖子包括内表面，并且被构造成附接到基座，使得基座和盖子一起提供容纳基底的空腔。 内表面包括中心区域和围绕中心区域设置的凹陷区域。 中心区域构造成覆盖反应区域，而凹陷区域在垂直于内表面的方向上偏离中心区域。
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公开(公告)号：US20140242596A1
公开(公告)日：2014-08-28
申请号：US14348881
申请日：2012-09-28
发明人： Ronald Danehy , Gary Lim , Jacob Freudenthal
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/50851 , B01L3/50855 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2300/0819 , B01L2300/0829 , B01L2300/0858 , B01L2300/0893 , B01L2300/161 , C12M23/12 , C12M23/38
摘要： A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
摘要翻译： 用于容纳多个生物样品的壳体包含基底，基底和盖。 底物附着到基底上，并且包括被配置成接收一个或多个生物样品的多个反应区域。 盖子包括内表面，并且被构造成附接到基座，使得基座和盖子一起提供容纳基底的空腔。 内表面包括中心区域和围绕中心区域设置的凹陷区域。 中心区域构造成覆盖反应区域，而凹陷区域在垂直于内表面的方向上偏离中心区域。
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公开(公告)号：US10821444B2
公开(公告)日：2020-11-03
申请号：US15457633
申请日：2017-03-13
发明人： Ronald Danehy , Jorge Fonseca , Jayanthi Prasad
摘要： A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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公开(公告)号：US10385383B2
公开(公告)日：2019-08-20
申请号：US15048324
申请日：2016-02-19
发明人： Ronald Danehy , Gary Lim , Jacob Freudenthal
IPC分类号： C12Q1/6806 , C12M1/32 , C12M1/00 , B01L3/00
摘要： A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
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公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
发明人： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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公开(公告)号：US20170182496A1
公开(公告)日：2017-06-29
申请号：US15457633
申请日：2017-03-13
发明人： Ronald Danehy , Jorge Fonseca , Jayanthi Prasad
CPC分类号： B01L3/56 , B01L3/0275 , B01L3/0293 , B01L2200/025 , B01L2300/161 , G01N35/1011 , G01N35/1074 , G01N2035/103
摘要： A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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公开(公告)号：US09604218B2
公开(公告)日：2017-03-28
申请号：US14020390
申请日：2013-09-06
发明人： Ronald Danehy , Jorge Fonseca , Jayanthi Prasad
CPC分类号： B01L3/56 , B01L3/0275 , B01L3/0293 , B01L2200/025 , B01L2300/161 , G01N35/1011 , G01N35/1074 , G01N2035/103
摘要： A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
发明人： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译： 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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