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公开(公告)号：US20240295499A1
公开(公告)日：2024-09-05
申请号：US18662295
申请日：2024-05-13
发明人： Kevin Maher , David Fortescue , Soo Yong Lau , Jacob K. Freudenthal , Woon Liang Terence SOH , Mingsong Chen , Ming Shen , Kuan Moon BOO
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
摘要： An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.
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公开(公告)号：US11815460B2
公开(公告)日：2023-11-14
申请号：US17825222
申请日：2022-05-26
发明人： Kevin Maher , Mingsong Chen , Jacob K. Freudenthal , Kuan Moon Boo , Soo Yong Lau , David Fortescue , Ming Shen , Woon Liang Terence Soh
CPC分类号： G01N21/6486 , G01N21/6428 , G01N21/6452 , G01N2021/6471 , G01N2021/6478 , G01N2201/062
摘要： A method of analyzing a plurality of biological sample volumes comprises emitting, along an excitation optical path toward a sample holder holding the plurality of biological sample volumes, electromagnetic radiation from a broadband LED, wherein the broadband LED emits the electromagnetic radiation across a range of wavelengths at a total output power of at least 5 watts and at a maximum intensity at a wavelength less than 600 nanometers and at an intensity less than 30 percent of the maximum intensity at a wavelength of 650 or 670 nanometers, and receiving, by a sensor, an electromagnetic emission transmitted from the sample holder along an emission optical path.
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公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
发明人： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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公开(公告)号：US10323274B2
公开(公告)日：2019-06-18
申请号：US14348504
申请日：2012-09-28
发明人： Jacob K. Freudenthal , Kevin Maher , Ming Song Chen , Theodore E. Straub , Kuan Moon Boo , Soo Yong Lau
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
发明人： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC分类号： C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
摘要： A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
摘要翻译： 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号：US20140294268A1
公开(公告)日：2014-10-02
申请号：US14348206
申请日：2012-09-30
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T5/008 , G06T5/50 , G06T2207/10024 , G06T2207/10064 , G06T2207/10144 , G06T2207/20021 , G06T2207/20216 , G06T2207/30072
摘要： A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.
摘要翻译： 提供了一种用于校准生物仪器的方法。 该方法包括以下步骤：获取至少一个生物样本阵列的图像，确定图像内的第一感兴趣区域，其中所述第一感兴趣区域包括所述至少一个生物阵列上的第一多个位置; 以及在所述第一感兴趣区域内识别与所述至少一个生物阵列上的所述第一多个位置中的每一个相关联的多个图像元素。
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公开(公告)号：US10591416B2
公开(公告)日：2020-03-17
申请号：US14766725
申请日：2014-02-24
发明人： Mingsong Chen , Mauro Aguanno , Kuan Moon Boo , Woon Liang Terence Soh , Jacob K. Freudenthal , Jeffrey A. Marks
摘要： An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
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公开(公告)号：US09495741B2
公开(公告)日：2016-11-15
申请号：US14348206
申请日：2012-09-30
CPC分类号： G06T7/0012 , G06T5/008 , G06T5/50 , G06T2207/10024 , G06T2207/10064 , G06T2207/10144 , G06T2207/20021 , G06T2207/20216 , G06T2207/30072
摘要： A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.
摘要翻译： 提供了一种用于校准生物仪器的方法。 该方法包括以下步骤：获取至少一个生物样本阵列的图像，确定图像内的第一感兴趣区域，其中所述第一感兴趣区域包括所述至少一个生物阵列上的第一多个位置; 以及在所述第一感兴趣区域内识别与所述至少一个生物阵列上的所述第一多个位置中的每一个相关联的多个图像元素。
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公开(公告)号：US12031916B2
公开(公告)日：2024-07-09
申请号：US17962123
申请日：2022-10-07
发明人： Mingsong Chen , Mauro Aguanno , Kuan Moon Boo , Woon Liang Terence Soh , Jacob K. Freudenthal , Jeffrey A. Marks
CPC分类号： G01N21/6486 , G01N21/0332 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2201/061 , G01N2201/0624 , G01N2201/0627 , G01N2201/121
摘要： An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.
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公开(公告)号：US11467092B2
公开(公告)日：2022-10-11
申请号：US16797561
申请日：2020-02-21
发明人： Mingsong Chen , Mauro Aguanno , Kuan Moon Boo , Woon Liang Terence Soh , Jacob K. Freudenthal , Jeffrey A. Marks
摘要： An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
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