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公开(公告)号：US10930373B2
公开(公告)日：2021-02-23
申请号：US15128859
申请日：2015-03-24
发明人： Nivedita Sumi Majumdar , Harrison Leong , Shakila Pothini , David Hoard , Christopher Fong , Pratik Simon Soares , Salil Kumar , Thomas Wessel , Manjula Aliminati , Levente Egry
IPC分类号： G16B50/00 , G16B30/00 , G16B45/00 , G06F16/904 , G06F16/951
摘要： A system for analyzing biological data, comprising: a storage configured to store a plurality of data files containing biological data obtained from a plurality of devices; a server configured to: host a plurality of applications, each configured to be implemented on the server and to provide analysis, manipulation, comparison, visualization, or a combination thereof, of the biological data included in the data files, wherein the plurality of applications allow a user to analyze different data files related to the same sample and compare the results of the analysis.
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公开(公告)号：US10197529B2
公开(公告)日：2019-02-05
申请号：US15130532
申请日：2016-04-15
发明人： David A. Denny , David Woo , Manjula Aliminati , Siva Kumar Samsani , Stephanie J. Schneider , Yoke Peng Lim , Sylvia Chang
IPC分类号： G01N27/447 , G06F19/22
摘要： In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes identifying features within the electropherogram data indicative of errors and validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.
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公开(公告)号：US11836614B2
公开(公告)日：2023-12-05
申请号：US16555803
申请日：2019-08-29
摘要： A system and methods are provided for image driven quality control for array based PCR. The system comprises a PCR unit, a reaction array plate, a convolutional neural network (CNN) configured to receive a sequence of images of the reaction array plate in the PCR system, and an output of the CNN coupled to a control for the reaction array plate. The method comprises applying a sequence of images from a plurality of subarrays of the reaction array plate to a plurality of CNNs during operation of the PCR system on the reaction plate array, operating the CNNs to generate failure mode predictions for the reaction plate based on the sequence of images, and coupling an output of the CNNs to one or more of a setting for manufacture of the reaction array plate or to control the PCR system.
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公开(公告)号：US20140236496A1
公开(公告)日：2014-08-21
申请号：US14347864
申请日：2012-09-28
发明人： Gordon A. Janaway , Manjula Aliminati , Ruoyun Wu , David Fortescue , Ming Shen
IPC分类号： G06F19/24
CPC分类号： G16B40/00 , C12Q1/6851 , C12Q2537/165 , C12Q2563/159
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.
摘要翻译： 提供了产生数字聚合酶链反应（dPCR）结果的计算机实现的方法。 该方法包括在放大期间的第一时间，从多个样本中检测出第一组发射数据，每个采样包括多个采样区域的样本区域。 该方法还包括部分地基于第一组发射数据确定多个样本中的每个样本的正或负放大确定。 基于多个样本的正或负放大确定产生dPCR结果。
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公开(公告)号：US10557821B2
公开(公告)日：2020-02-11
申请号：US16265806
申请日：2019-02-01
发明人： David Denny , David Woo , Manjula Aliminati , Siva Kumar Samsani , Stephanie Schneider , Yoke Peng Lim , Sylvia Chang
IPC分类号： G01N27/447 , G16B30/00
摘要： In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.
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公开(公告)号：US10453557B2
公开(公告)日：2019-10-22
申请号：US14347864
申请日：2012-09-28
发明人： Gordon A. Janaway , Manjula Aliminati , Ruoyun Wu , David Fortescue , Ming Shen
IPC分类号： G16B40/00 , C12Q1/6851
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.
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公开(公告)号：US20200035329A1
公开(公告)日：2020-01-30
申请号：US16590303
申请日：2019-10-01
发明人： Gordon A. Janaway , Manjula Aliminati , Ruoyun Wu , David Fortescue , Ming Shen
IPC分类号： G16B40/00 , C12Q1/6851
摘要： A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting of emission data from a planiality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data, A dPCR result is generated based on the positive amplification determinations for the plurality of samples.
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公开(公告)号：US20160313280A1
公开(公告)日：2016-10-27
申请号：US15130532
申请日：2016-04-15
发明人： David A. Denny , David Woo , Manjula Aliminati , Siva Kumar Samsani , Stephanie J. Schneider , Yoke Peng Lim , Sylvia Chang
IPC分类号： G01N27/447
CPC分类号： G01N27/44717 , G06F19/22
摘要： In one exemplary embodiment, a method for detecting variants in electropherogram data is provided. The method includes receiving electropherogram data from an instrument and analyzing the electropherogram data to identify mixed bases in the electropherogram data. The method further includes identifying features within the electropherogram data indicative of errors and validating the identified mixed bases. Then the method includes determining variants in the electropherogram data based on the validated mixed bases.
摘要翻译： 在一个示例性实施例中，提供了一种用于检测电泳图数据中的变体的方法。 该方法包括从仪器接收电泳图数据，并分析电泳图数据以识别电泳图数据中的混合碱基。 该方法还包括识别电泳图中指示错误并验证所识别的混合碱基的特征。 然后该方法包括基于经验证的混合碱基来确定电泳图数据中的变体。
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