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    MICROSATELLITE INSTABILITY MEASUREMENT
    2.
    发明申请
    MICROSATELLITE INSTABILITY MEASUREMENT 有权

    公开(公告)号：US20210139950A1

    公开(公告)日：2021-05-13

    申请号：US17092194

    申请日：2020-11-06

    Applicant: Life Technologies Corporation

    Inventor： Harrison Leong ,  Charles Baudo ,  Charles Wendell Higdon, III

    IPC: C12Q1/686 ,  C12Q1/6883 ,  G01N21/64

    Abstract: Systems and methods for detecting microsatellite instability in a biological sample are described. Signal data is received from a capillary electrophoresis genetic analysis instrument, wherein the signal data is measured from fluorescence of fragments comprising nucleic acid sequences amplified from the biological sample via polymerase chain reaction (PCR). The nucleic acid sequences correspond to a plurality of different microsatellite loci and are obtained using a plurality of PCR primers configured to flank a plurality of microsatellite loci of a biological sample. When the PCR primers and the biological sample are combined and subjected to PCR amplification, fluorescently labeled DNA fragments are generated comprising the plurality of microsatellite loci. Fluorescent data obtained from the plurality of fluorescently labelled microsatellite loci are used to classify microsatellite instability of the biological sample.

    SYSTEMS AND METHODS FOR THE ANALYSIS OF PROXIMITY BINDING ASSAY DATA
    4.
    发明申请
    SYSTEMS AND METHODS FOR THE ANALYSIS OF PROXIMITY BINDING ASSAY DATA 审中-公开

    公开(公告)号：US20180330047A1

    公开(公告)日：2018-11-15

    申请号：US15967501

    申请日：2018-04-30

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison Leong ,  Nivedita Sumi Majumdar ,  Elana E Swartzman

    IPC: G06F19/18 ,  G06F19/24

    CPC classification number: G06F19/18 ,  G06F19/24

    Abstract: A proximity binding assay (PBA) is performed on at least one test sample, at least one reference sample, a background sample, and one or more calibration samples using a thermal cycler instrument. Ct values are determined for at least one set of test sample data and at least one set of reference sample data. Background corrected Ct values are calculated using a corresponding value in a background sample data set. A linear range is determined for the background corrected Ct values as a function of sample quantity. A linear regression line is calculated for each linear range. One or more parameter values of an exponential model (EM) fold change formula are estimated from the one or more sets of calibration sample data. A target protein quantity and associated confidence interval are calculated using the linear regression lines and the EM fold change formula.

    METHODS AND SYSTEMS FOR DETECTING MINOR VARIANTS IN A SAMPLE OF GENETIC MATERIAL
    5.
    发明申请
    METHODS AND SYSTEMS FOR DETECTING MINOR VARIANTS IN A SAMPLE OF GENETIC MATERIAL 审中-公开

    公开(公告)号：US20170235874A1

    公开(公告)日：2017-08-17

    申请号：US15504299

    申请日：2015-08-14

    Applicant: Life Technologies Corporation

    Inventor： Harrison Leong ,  Edgar Schreiber

    IPC: G06F19/18 ,  G06F19/24 ,  G01N27/447

    CPC classification number: G16B20/00 ,  G16B40/00

    Abstract: A computer-implemented method for determining minor variants. The method includes receiving electropherogram sequence data from a test sample, identifying any non-primary peaks in the electropherogram, and characterizing identified non-primary peaks using at least one signal feature. The method may further include analyzing the at least one signal feature across identified non-primary peaks to identify variant candidates, evaluating at least one peak characteristic of each of the identified variant candidates, and classifying variant candidates as bona fide variants based on the evaluation of peak characteristics.

    Methods and Systems for Visualizing Data Quality
    6.
    发明申请
    Methods and Systems for Visualizing Data Quality 审中-公开
    数据质量可视化方法与系统

    公开(公告)号：US20160275149A1

    公开(公告)日：2016-09-22

    申请号：US14392323

    申请日：2014-06-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Nivedita Sumi Majumdar ,  Harrison Leong ,  Theodore E. Straub ,  David Hoard

    IPC: G06F17/30

    CPC classification number: G06F16/24575 ,  G06F16/248 ,  G16B45/00

    Abstract: A method for generating a data visualization is provided. The method includes receiving a plurality of data points related to fluorescent emissions values from a plurality of reaction sites. The fluorescent emission values include information for a first type of dye and a second type of dye. The method further includes displaying a first portion of the plurality of data points related to the first type of dye in a representation of location of the plurality of reaction sites, and displaying a second portion of the plurality of data points related to the second type of dye in the representation. The method further includes displaying the first portion of the plurality of data points in a scatter plot display. The scatter plot shows fluorescent values related to the first dye on the y-axis and fluorescent values related to the second dye on the x-axis. The method includes displaying the second portion of the plurality of data points in the scatter plot display.

    Abstract translation: 提供了一种用于生成数据可视化的方法。 该方法包括从多个反应位点接收与荧光发射值有关的多个数据点。 荧光发射值包括第一类染料和第二类染料的信息。 该方法还包括在多个反应位置的位置的表示中显示与第一类型的染料相关的多个数据点的第一部分，以及显示与第二类型的染色相关的多个数据点的第二部分 染料代表。 该方法还包括在散点图显示中显示多个数据点的第一部分。 散点图显示与y轴上的第一染料相关的荧光值和与x轴上的第二染料相关的荧光值。 该方法包括在散点图显示中显示多个数据点的第二部分。

    Methods and systems for detecting minor variants in a sample of genetic material
    7.
    发明授权
    Methods and systems for detecting minor variants in a sample of genetic material 有权

    公开(公告)号：US10910086B2

    公开(公告)日：2021-02-02

    申请号：US15504299

    申请日：2015-08-14

    Applicant: Life Technologies Corporation

    Inventor： Harrison Leong ,  Edgar Schreiber

    IPC: G01N33/48 ,  G16B20/00 ,  G16B40/00 ,  G06G7/58

    Abstract: A computer-implemented method for determining minor variants. The method includes receiving electropherogram sequence data from a test sample, identifying any non-primary peaks in the electropherogram, and characterizing identified non-primary peaks using at least one signal feature. The method may further include analyzing the at least one signal feature across identified non-primary peaks to identify variant candidates, evaluating at least one peak characteristic of each of the identified variant candidates, and classifying variant candidates as bona fide variants based on the evaluation of peak characteristics.

    Methods and systems for determining meta-genotypes
    8.
    发明授权
    Methods and systems for determining meta-genotypes 有权

    公开(公告)号：US10007753B2

    公开(公告)日：2018-06-26

    申请号：US14759496

    申请日：2014-01-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison Leong

    IPC: G01N33/48 ,  G06F19/18 ,  G01N33/49 ,  G06F19/28 ,  G06G7/58

    CPC classification number: G16B20/00 ,  G01N33/49 ,  G16B50/00

    Abstract: In one exemplary embodiment, a computer-implemented method for determining a genetic result from a biological sample is provided. The method includes receiving nucleic acid amplification data of a biological sample, by a processor, from a biological instrument. The method further includes storing translation data, in a memory. The translation data includes a pattern of assay values associated with possible genetic results. The method further includes comparing the translation data with the nucleic acid amplification data, by the processor, to generate the genetic result of the biological sample. Moreover, the method includes displaying the genetic result, on a display, to a user.

    Visualization Tools For Digital PCR Data
    10.
    发明申请
    Visualization Tools For Digital PCR Data 审中-公开
    数字PCR数据可视化工具

    公开(公告)号：US20150269756A1

    公开(公告)日：2015-09-24

    申请号：US14441500

    申请日：2013-11-07

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison Leong ,  Nivedita Sumi Majumdar ,  Jeffrey A. Marks ,  Theodore E. Straub ,  Ryan J. Talbot ,  Kevin S. Bodner ,  David Hoard

    IPC: G06T11/20

    CPC classification number: G06T11/206 ,  G06T11/203 ,  G16B45/00

    Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.

    Abstract translation: 提供了一种用于生成数据可视化的方法。 该方法包括将检测到的数据的一部分从衬底显示给用户。 该方法还包括为检测到的数据的部分生成数据质量值，以及与检测到的数据的部分的表示一起显示检测到的数据的部分的数据质量值的指示。 该方法还包括由用户选择质量值阈值，并且显示对于满足质量值阈值的检测数据的部分的数据质量值的调整指示。

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