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公开(公告)号：US12186510B2
公开(公告)日：2025-01-07
申请号：US17192612
申请日：2021-03-04
Applicant: The Medical Research, Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center , V-Wave Ltd.
Inventor： Gad Keren
Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.
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2.发明授权
公开(公告)号：US12023348B2
公开(公告)日：2024-07-02
申请号：US15569407
申请日：2016-04-26
Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Ofer Sarig , Eli Sprecher
IPC: A61K31/704 , A61K31/122 , A61K31/137 , A61K31/167 , A61K31/277 , A61K31/365 , A61K31/366 , A61K31/37 , A61K31/404 , A61K31/423 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4738 , A61K31/4741 , A61K31/4745 , A61K31/475 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61K31/566 , A61K31/58 , A61K31/688 , A61K45/06 , A61P17/00 , A61P17/06
CPC classification number: A61K31/704 , A61K31/122 , A61K31/137 , A61K31/167 , A61K31/277 , A61K31/365 , A61K31/366 , A61K31/37 , A61K31/404 , A61K31/423 , A61K31/427 , A61K31/433 , A61K31/4402 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4738 , A61K31/4741 , A61K31/4745 , A61K31/475 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61K31/566 , A61K31/58 , A61K31/688 , A61K45/06 , A61P17/00 , A61P17/06
Abstract: A method of treating an inflammation or a hyperproliferative disease in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:
a compound represented by Formula I:
or a pharmaceutically acceptable salt thereof,
a compound represented by Formula II:
and a compound represented by Formula III:
wherein the variables in Formulae I, II and III are as defined in the specification.
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公开(公告)号：US20220125824A1
公开(公告)日：2022-04-28
申请号：US17572210
申请日：2022-01-10
Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Nadir ARBER , Shiran SHAPIRA , Dina KAZANOV
IPC: A61K31/713 , A61K45/06 , C12N15/86 , C12N15/63 , C12N15/09 , A61K35/761 , A61P35/00 , A61K48/00
Abstract: Provided are nucleic acid constructs and systems which comprise (i) a first nucleic acid construct encoding a toxin operatively linked to a first promoter and at least one cancer-associated signaling responsive enhancer element; and (ii) a second nucleic acid construct encoding an anti-toxin operatively linked to a second promoter, the second promoter being stronger than the first promoter.
Also provided are pharmaceutical compositions comprising same and methods of using same for treating cancer.
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公开(公告)号：US11065118B2
公开(公告)日：2021-07-20
申请号：US14772394
申请日：2014-03-04
Applicant: The Medical Research, Infrastructure and Health Services Fund Of The Tel-Aviv Medical Center
Inventor： Gad Keren , Allan C. Entis
IPC: A61F2/24
Abstract: A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and bottom gripping wings face each other to grip the annulus between them and the second top and bottom gripping wings face each other to grip the annulus between them.
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公开(公告)号：US10945641B2
公开(公告)日：2021-03-16
申请号：US14350567
申请日：2012-10-09
Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Anat Mirelman , Jeffrey M. Hausdorff , Nir Giladi
IPC: A61B5/11 , A61B5/00 , A61B5/0476 , A61B5/16 , G06F19/00 , A61B5/0484 , A61B5/0205 , A61B5/026
Abstract: Methods and/or systems for diagnosing, monitoring and/or treating persons at risk for falling and/or other pathological conditions. In an exemplary embodiment of the invention, people are diagnosed before they actually start falling. Optionally, the diagnosis includes trying out and identifying one or more fall triggers using virtual reality tools. Optionally or alternatively, treatment includes training the persons using situations and/or triggers which are determined to be relevant for that person.
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公开(公告)号：US20200022895A1
公开(公告)日：2020-01-23
申请号：US16039427
申请日：2018-07-19
Applicant: The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical Center
Inventor： Amir INBAL , Andrew GREENSMITH , Nir SHANI
Abstract: The invention provides a method for skin expansion utilizing at least one polymer.
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公开(公告)号：US20190329063A1
公开(公告)日：2019-10-31
申请号：US16473256
申请日：2017-12-21
Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Talma HENDLER , Gal RAZ , Roy Itzhak SAR-EL
IPC: A61N2/00 , A61K31/4458 , A61K31/198 , A61K31/4515 , A61G10/02 , A61N1/36 , A61M21/02
Abstract: A method for modifying the effect of a drug by application of an activation protocol, comprising: administering a drug according to a treatment protocol; applying an activation protocol in a timed relationship to the administering, for differentially activation of at least one selected brain region; wherein the differentially activation allows the drug to selectively interact with the at least one selected brain region.
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公开(公告)号：US20180155691A1
公开(公告)日：2018-06-07
申请号：US15579802
申请日：2016-06-09
Applicant: The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical Center
Inventor： Nir SHANI , Eyal GUR , Inna SOLODEEV , Anna ARONOVICH
IPC: C12N5/0775 , C12M1/33 , C12M1/00 , A61M1/00
CPC classification number: C12N5/0667 , A61M1/0023 , A61M1/0094 , A61M2202/08 , B01L3/502 , B01L2300/0681 , B01L2400/0478 , B01L2400/049 , C12M45/02 , C12M47/04 , C12N5/0653 , C12N2527/00
Abstract: Provided is an apparatus and process for isolation of stromal vascular fraction (SVF) following lipoaspiration.
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公开(公告)号：US09949852B2
公开(公告)日：2018-04-24
申请号：US15008929
申请日：2016-01-28
Applicant: Vascular Graft Solutions Ltd. , The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Eyal Orion , Yehuda Bachar , Yanai Ben-Gal , Avraham Rapaport , Gilad Cibulski , Ronny Winshtein
CPC classification number: A61B17/11 , A61B17/12 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2/82 , A61F2/90
Abstract: Implant for supporting bodily conduits, such as blood vessels or/and grafted vessels, inside a subject. In exemplary embodiments, the implant includes a support fixedly displaceable and plastically stretchable to points along longitudinal axis of the support, when subjected to a stretching force, thereby forming a new shape, the support substantially maintains the new shape upon removal of the stretching force. The support, when forming the new shape, is plastically reversely compressible in a direction along the support longitudinal axis, when subjected to axially compressive force. Support may include a radially elastic portion configured to regain fixedly deformed diameter upon removal of radially compressive force applied thereto. Support is configurable as an intraluminal support for intraluminal deployment and setting in a conduit segment, or, as an external support for enveloping a conduit segment, so as to change route or/and shape of the conduit segment.
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公开(公告)号：US20170258370A1
公开(公告)日：2017-09-14
申请号：US15607548
申请日：2017-05-29
Applicant: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Meir PLOTNIK-PELEG , Jeffrey M. HAUSDORFF , Nir GILADI , Anat MIRELMAN
IPC: A61B5/11 , A61B5/0476
CPC classification number: A61B5/1104 , A61B5/0205 , A61B5/026 , A61B5/0476 , A61B5/04842 , A61B5/1117 , A61B5/1118 , A61B5/112 , A61B5/162 , A61B5/7203 , A61B5/7257 , A61B5/744 , A61B2505/09 , G06F19/00
Abstract: A method and system for provoking gait disorders, such as freezing of gait; usable, for example, for diagnosing and/or treatment thereof. In an exemplary embodiment of the invention, displays of situations calculated to cause freezing of gait are presented to a subject, optionally using virtual reality displays. Optionally or alternatively, incipit freezing of gait is identified using changes in gait parameters, and optionally used to guide attempts at causing freezing of gait. Optionally or alternatively, a portable device is provided which detects incipit freezing of gait and generates a corrective signal to the subject.
