摘要:
Provided are nucleic acid constructs and systems which comprise (i) a first nucleic acid construct encoding a toxin operatively linked to a first promoter and at least one cancer-associated signaling responsive enhancer element; and (ii) a second nucleic acid construct encoding an anti-toxin operatively linked to a second promoter, the second promoter being stronger than the first promoter. Also provided are pharmaceutical compositions comprising same and methods of using same for treating cancer.
摘要:
A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and bottom gripping wings face each other to grip the annulus between them and the second top and bottom gripping wings face each other to grip the annulus between them.
摘要:
Methods and/or systems for diagnosing, monitoring and/or treating persons at risk for falling and/or other pathological conditions. In an exemplary embodiment of the invention, people are diagnosed before they actually start falling. Optionally, the diagnosis includes trying out and identifying one or more fall triggers using virtual reality tools. Optionally or alternatively, treatment includes training the persons using situations and/or triggers which are determined to be relevant for that person.
摘要:
A method for modifying the effect of a drug by application of an activation protocol, comprising: administering a drug according to a treatment protocol; applying an activation protocol in a timed relationship to the administering, for differentially activation of at least one selected brain region; wherein the differentially activation allows the drug to selectively interact with the at least one selected brain region.
摘要:
Implant for supporting bodily conduits, such as blood vessels or/and grafted vessels, inside a subject. In exemplary embodiments, the implant includes a support fixedly displaceable and plastically stretchable to points along longitudinal axis of the support, when subjected to a stretching force, thereby forming a new shape, the support substantially maintains the new shape upon removal of the stretching force. The support, when forming the new shape, is plastically reversely compressible in a direction along the support longitudinal axis, when subjected to axially compressive force. Support may include a radially elastic portion configured to regain fixedly deformed diameter upon removal of radially compressive force applied thereto. Support is configurable as an intraluminal support for intraluminal deployment and setting in a conduit segment, or, as an external support for enveloping a conduit segment, so as to change route or/and shape of the conduit segment.
摘要:
A method and system for provoking gait disorders, such as freezing of gait; usable, for example, for diagnosing and/or treatment thereof. In an exemplary embodiment of the invention, displays of situations calculated to cause freezing of gait are presented to a subject, optionally using virtual reality displays. Optionally or alternatively, incipit freezing of gait is identified using changes in gait parameters, and optionally used to guide attempts at causing freezing of gait. Optionally or alternatively, a portable device is provided which detects incipit freezing of gait and generates a corrective signal to the subject.
摘要:
A method for reconstructing high signal-to-noise ratio (SNR) magnetic resonance imaging (MRI) slices, including: receiving a thick MRI slice of bodily tissue acquired using a single MRI scan, wherein the thick slice has a high SNR; receiving two thin MRI slices of the bodily tissue acquired using a single MRI scan, wherein each of the two thin MRI slices has a low SNR; and reconstructing multiple high SNR thin slices of the bodily tissue using the thick slice and the two thin slices.
摘要:
Implant for supporting bodily conduits, such as blood vessels or/and grafted vessels, inside a subject. In exemplary embodiments, the implant includes a support fixedly displaceable and plastically stretchable to points along longitudinal axis of the support, when subjected to a stretching force, thereby forming a new shape, the support substantially maintains the new shape upon removal of the stretching force. The support, when forming the new shape, is plastically reversely compressible in a direction along the support longitudinal axis, when subjected to axially compressive force. Support may include a radially elastic portion configured to regain fixedly deformed diameter upon removal of radially compressive force applied thereto. Support is configurable as an intraluminal support for intraluminal deployment and setting in a conduit segment, or, as an external support for enveloping a conduit segment, so as to change route or/and shape of the conduit segment.