公开(公告)号：US20220177422A1

公开(公告)日：2022-06-09

申请号：US17594086

申请日：2020-04-02

Applicant: The University of Chicago ,  The United States of America,as Represented by the Secretary, Department of Health and Human Servic ,  President and Fellows of Harvard College ,  IIT Research Institute ,  Beth Israel Deaconess Medical Center, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  THE TRUSTEES OF PURDUE UNIVERSITY

Inventor： Julian SOLWAY ,  Nickolai DULIN ,  Diane Luci ,  David MALONEY ,  Chan Young PARK ,  Jeffrey FREDBERG ,  David MCCORMICK ,  Ramaswamy KRISHNAN

IPC: C07C311/46 ,  C07D207/48 ,  C07D211/96 ,  C07D277/52 ,  C07D295/26 ,  A61P11/00

Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

公开(公告)号：US20040124916A1

公开(公告)日：2004-07-01

申请号：US10331930

申请日：2002-12-31

Applicant: IIT Research Institute

Inventor： Kalle R. Kontson

IPC: H03F001/14

CPC classification number: H03C5/00 ,  H03F1/32 ,  H03F3/72 ,  H03F2203/7215 ,  H03F2203/7236

Abstract: At least one amplifier is selected from a first bank of non-linear amplifiers. At least one amplifier is selected from a second bank of non-linear amplifiers. The number of amplifiers selected from the first and second banks remains constant. Using the selected amplifiers, first and second components of a digital symbol are amplified using the first and second banks, respectively. The outputs produced by first and second banks are combined to produce an analog representation of the digital symbol.

Abstract translation: 从第一组非线性放大器中选择至少一个放大器。 从第二组非线性放大器中选择至少一个放大器。 从第一和第二组选择的放大器的数量保持不变。 使用所选择的放大器，数字符号的第一和第二分量分别使用第一和第二存储体进行放大。 由第一和第二组产生的输出被组合以产生数字符号的模拟表示。

公开(公告)号：US20030192001A1

公开(公告)日：2003-10-09

申请号：US10116132

申请日：2002-04-05

Applicant: IIT Research Institute

Inventor： Michael Anthony Maiuzzo ,  Kenneth Kahle Roberts

IPC: H03M013/00

CPC classification number: H03M13/2936 ,  H03M13/154 ,  H03M13/45 ,  H03M13/6325

Abstract: A method and apparatus for decoding forward error correction (FEC) encoded data. A stream of units of FEC encoded bits are received, where the units are derived from a transmitted signal, where each unit represents a one-bit data value, and where each unit includes correctness bits that together reflect a level of probability that the one-bit data value represented by the unit differs from corresponding bits in the signal before it was transmitted. The stream of units of FEC encoded bits are decoded by using the quality level of bits to perform soft-decision convolution decoding on the stream of units of FEC bits, where the soft-decision convolution decoding produces, for block decoding, a stream of symbols made up of bits. In the stream of units of FEC bits, subsequences of units that are prone to erroneous soft-decision convolution decoding are detected by determining, for the sub-sequences whether the distribution of quality bits indicate the units are below a threshold level of correctness, and by comparing characteristics of that distribution to a given set of characteristics predetermined to be prone to result in incorrect decoding. Among the symbols produced for block decoding, symbols containing one or more bits that correspond to units that were in subsequences detected to be prone to erroneous soft-decision convolution decoding are flagged or tagged, and thereby, errors in the stream of symbols may be soft-decision block decoded by erasing the flagged symbols.

Abstract translation: 用于解码前向纠错（FEC）编码数据的方法和装置。 接收FEC编码比特流的流，其中单位是从发送信号导出的，其中每个单位表示一比特数据值，并且其中每个单元包括一起反映一次性概率水平的正确比特， 由单元表示的位数据值与发送前的信号中的相应位不同。 通过使用比特质量级对FEC编码比特的单位流进行解码，以对FEC比特单元流进行软判决卷积解码，其中软判决卷积解码产生用于块解码的符号流 由位组成。 在FEC比特单元流中，通过对于子序列确定质量比特的分配是否指示单位的阈值水平低于正确性的阈值来检测容易出现错误的软判决卷积解码的单元的子序列，以及 通过将该分布的特征与预定为容易导致不正确解码的给定特征集进行比较。 在为块解码产生的符号中，包含与被检测为容易出现错误的软判决卷积解码的子序列中的单元相对应的一个或多个位的符号被标记或标记，从而符号流中的错误可能是软的 - 通过擦除标记的符号来解码块。

公开(公告)号：US20020112754A1

公开(公告)日：2002-08-22

申请号：US10001008

申请日：2001-11-02

Applicant: IIT Research Institute

Inventor： James R. Gauger ,  Robert L. Mullins ,  George L. Stefanek ,  Joseph J. Petrovic

IPC: E04H015/36

CPC classification number: A62B31/00 ,  A61B90/40 ,  A61G1/0212 ,  A61G1/0293 ,  A61G10/005 ,  A61G2210/30

Abstract: A collapsible personnel isolation apparatus for preventing unwanted contaminations of hazardous biological and chemical materials including a base. A cover connects to the base by way of a zipper. A plurality of glove box ports are provided to allow rapid and convenient treatment of the patient.

Abstract translation: 一种用于防止有害的生物和化学材料（包括基底）的不必要的污染的可折叠人员隔离装置。 盖子通过拉链连接到基座。 提供多个手套箱端口以允许对患者的快速和方便的治疗。

公开(公告)号：US20220323415A1

公开(公告)日：2022-10-13

申请号：US17808645

申请日：2022-06-24

Applicant: Michael J. KATES ,  The University of Chicago ,  IIT Research Institute

Inventor： Michael J. KATES ,  Nanduri R. PRABHAKAR ,  David L. MCCORMICK ,  Miguel MUZZIO

IPC: A61K31/4164 ,  A61P11/00 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/221 ,  A61K31/275 ,  A61K31/381 ,  A61K45/06 ,  C07C229/30 ,  C07C255/07 ,  C07D277/30 ,  C07D333/24

Abstract: Described herein are novel γ- and δ-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.

公开(公告)号：US20240415851A1

公开(公告)日：2024-12-19

申请号：US18605319

申请日：2024-03-14

Applicant: The University of Chicago ,  The United States of America, as Represented by the Secretary, Department of Health and Human ,  President and Fellows of Harvard College ,  IIT Research Institute ,  Beth Israel Deaconess Medical Center, Inc.

Inventor： Julian SOLWAY ,  Nickolai DULIN ,  Marsha ROSNER ,  Gokhan MUTLU ,  Diane LUCI ,  David MALONEY ,  Chan Young PARK ,  Jeffrey FREDBERG ,  David MCCORMICK ,  Ramaswamy KRISHNAN

IPC: A61K31/635 ,  A61K31/18 ,  A61K31/63 ,  A61P35/04 ,  C07C311/16 ,  C07C311/21 ,  C07D207/48 ,  C07D211/34 ,  C07D211/96 ,  C07D239/42 ,  C07D241/04 ,  C07D265/30 ,  C07D277/52 ,  C07D279/12 ,  C07D295/13 ,  C07D295/26 ,  C07D309/14 ,  C07D401/12 ,  C07D471/04 ,  C07D487/08 ,  C07D491/113

Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

公开(公告)号：US20210085648A1

公开(公告)日：2021-03-25

申请号：US15929512

申请日：2020-05-06

Applicant: Michael J. KATES ,  The University of Chicago ,  IIT Research Institute

Inventor： Michael J. KATES ,  Nanduri R. PRABHAKAR ,  David L. MCCORMICK ,  Miguel MUZZIO

IPC: A61K31/4164 ,  A61K31/197 ,  C07C229/30 ,  C07D277/30 ,  A61P11/00 ,  A61K31/381 ,  A61K31/221 ,  C07C255/07 ,  A61K31/198 ,  A61K31/275 ,  A61K31/216 ,  A61K45/06 ,  C07D333/24

Abstract: Described herein are novel γ- and δ-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.