公开(公告)号：US12071645B2

公开(公告)日：2024-08-27

申请号：US17900590

申请日：2022-08-31

申请人： Givaudan SA

发明人： Eric Eichhorn ,  Boris Schilling ,  Denis Wahler ,  Laurent Fourage ,  Esther Locher

IPC分类号： C12P17/04 ,  C07D307/92 ,  C12N9/90

CPC分类号： C12P17/04 ,  C07D307/92 ,  C12N9/90

摘要： There is provided SHC/HAC derivatives, amino acid sequences comprising the SHC/HAC derivatives, nucleotide sequences encoding the SHC/HAC derivatives, vectors comprising nucleotide sequences encoding the SHC/HAC derivatives, recombinant host cells comprising nucleotide sequences encoding the SHC/HAC derivatives and applications of the recombinant host cells comprising either SHC/HAC derivatives or WT SHC/HAC enzymes in methods to prepare (−)-Ambrox and SHC/HAC enzymes in methods to prepare (−)-Ambrox.

公开(公告)号：US12037623B2

公开(公告)日：2024-07-16

申请号：US17257792

申请日：2019-07-02

申请人： Merck Sharp & Dohme Corp.

发明人： Mark A. Huffman ,  Anna Fryszkowska ,  Joshua N. Kolev ,  Paul N. Devine ,  Kevin R. Campos ,  Matthew Truppo ,  Christopher C. Nawrat

IPC分类号： C12P19/40 ,  C07C33/042 ,  C07F9/113 ,  C07H13/00 ,  C12P7/18 ,  C12P9/00 ,  C12P17/04

CPC分类号： C12P19/40 ,  C07C33/042 ,  C07F9/113 ,  C07H13/00 ,  C12P7/18 ,  C12P9/00 ,  C12P17/04

摘要： The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

公开(公告)号：US20230250390A1

公开(公告)日：2023-08-10

申请号：US17947421

申请日：2022-09-19

申请人： Prospective Research, Inc.

发明人： Dakota Benjamin Hamill ,  Jake J. Cotter

IPC分类号： C12N1/38 ,  C12N15/80 ,  C12N1/12 ,  C12P17/04 ,  C07D307/33 ,  C12P1/04 ,  C12P17/16 ,  C12P1/06

CPC分类号： C12N1/38 ,  C12N15/80 ,  C12N1/12 ,  C12P17/04 ,  C07D307/33 ,  C12P1/04 ,  C12P17/165 ,  C12P1/06

摘要： Methods and compositions herein provide non-naturally occurring γ-butyrolactones (GBLs) in racemic mixtures that increase efficiency and effectiveness of screening for production of antibiotics, and enhance yields and express silent pathways. Non-naturally occurring GBLs were synthesized and found to stimulate antibiotic production in several different streptomycete strains. Antibiotic production by Streptomyces coelicolor was induced by a racemic mixture of non-cognate stereoisomers of VB-D, seven of which are non-naturally occurring. Further, novel A-factor-type GBL analogs stimulated antibiotic production in S. coelicolor. Synthesis in response to the treatment with the non-cognates GBL was observed for known compounds including undecylprodigiosin, desferrioxamine and streptorubin B, as was synthesis of a compound of unknown structure. A group of 37 additional microbial strains was screened by principal component analysis to determine optimal concentrations of each of a panel of four non-cognate synthetic GBLs for addition to cultures with optimal stimulation of secondary metabolites, and large scale fermentations were analyzed and product enhancement by the GBLs was observed.

公开(公告)号：US20230212624A1

公开(公告)日：2023-07-06

申请号：US18018360

申请日：2021-07-29

申请人： Givaudan SA

发明人： Jean-Pierre BARRAS ,  Sylvie MOREL ,  Eric EICHHORN

IPC分类号： C12P17/04 ,  C12N9/90

CPC分类号： C12P17/04 ,  C12N9/90 ,  C12Y504/99017

摘要： A method for purifying a crude flavor or perfumery or cosmetic ingredient or intermediate, for example crude (−)-Ambrox, comprising a number of washing steps, the products of said method, and uses of said product.

公开(公告)号：US20180179498A1

公开(公告)日：2018-06-28

申请号：US15737729

申请日：2016-06-16

申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

发明人： Vidya Shrikant GUPTA ,  Hemangi Girish CHIDLEY ,  Ashish Balwant DESHPANDE ,  Ashok Prabhakar GIRI

IPC分类号： C12N9/10 ,  C12P17/04 ,  C12P7/42 ,  C12P7/22 ,  C12P7/24

CPC分类号： C12N9/1007 ,  C12P7/22 ,  C12P7/24 ,  C12P7/42 ,  C12P17/04

摘要： The present invention relates to the cloning and expression of cDNA encoding O-methyl transferase for catalyzing the synthesis of vital volatile flavor compounds such as mesifuran and vanillin, thereby playing a significant role in flavor biochemistry of mango. The present invention also provide a process for the preparation of volatile compounds by mesifuran, ferulic acid, guaiacol and vanillin, specifically mesifuran and vanillin using cDNA sequence.

公开(公告)号：US20180168166A1

公开(公告)日：2018-06-21

申请号：US15883532

申请日：2018-01-30

申请人： Marrone Bio Innovations, Inc.

发明人： Ratnakar Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana-Lucia Cordova Kreylos ,  Huazhang Huang

IPC分类号： A01N63/00 ,  A01N63/02 ,  C07D309/14 ,  A01N43/90 ,  A01N43/16 ,  A01N43/76 ,  C12P17/04 ,  A01N43/86 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D263/32 ,  C12R1/01 ,  C12P17/16 ,  C12P17/14 ,  C12P17/06 ,  C12N1/20 ,  C07D513/04 ,  C07D498/14 ,  C07D493/10 ,  C07D263/34 ,  A01N43/74

CPC分类号： A01N43/76 ,  A01N43/00 ,  A01N43/16 ,  A01N43/86 ,  A01N43/90 ,  A01N63/00 ,  A01N63/02 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12R1/00 ,  C12R1/01 ,  A01N43/74

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US09938547B2

公开(公告)日：2018-04-10

申请号：US14900182

申请日：2014-06-20

申请人： Technische Universiteit Delft

发明人： Jacob van Spronsen ,  Geert-Jan Witkamp ,  Bart de Graaff

IPC分类号： C12P17/04 ,  C07D307/68

CPC分类号： C12P17/04 ,  C07D307/68

摘要： The invention is directed to a process for the preparation of 2,5-furandicarboxylic acid (FDCA) by fermentation comprising fermenting a suitable starting compound to produce an aqueous solution of a salt of FDCA having a pH of at least 7, optionally removing solids from said solution, e.g. by filtration, subsequently freeze crystallizing the said salt of FDCA from said solution at said pH, isolating the said FDCA salt in the form of solid crystals, preparing an aqueous solution of said salt and crystallizing FDCA as the free acid from said solution at an acidic pH.

公开(公告)号：US09918479B2

公开(公告)日：2018-03-20

申请号：US14376696

申请日：2013-02-27

申请人： Marrone Bio Innovations, Inc.

发明人： Ratnakar Asolkar ,  Ana Lucia Cordova-Kreylos ,  Carly Todd

IPC分类号： A01N63/00 ,  A01N63/02 ,  A01N37/06 ,  A01N37/36 ,  C07G99/00 ,  C12P1/04 ,  A01N43/08 ,  C12P7/64 ,  C12P17/04

CPC分类号： A01N63/00 ,  A01N37/06 ,  A01N37/36 ,  A01N43/08 ,  A01N63/02 ,  C07G17/00 ,  C12P1/04 ,  C12P7/6409 ,  C12P17/04

摘要： Provided are compounds and compositions derived from Pseudomonas sp., particularly, Pseudomonas fluorescens or Pseudomonas protegens and more particularly strain having the identifying characteristics of Pseudomonas ATCC 55799 having antimicrobial properties and particularly, antibacterial properties.

公开(公告)号：US09796992B2

公开(公告)日：2017-10-24

申请号：US14084030

申请日：2013-11-19

申请人： BASF SE

发明人： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

IPC分类号： C12N1/21 ,  C12P17/04 ,  C12N15/52 ,  C12P7/50

CPC分类号： C12P17/04 ,  C12N15/52 ,  C12P7/50

摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

公开(公告)号：US09790526B2

公开(公告)日：2017-10-17

申请号：US14376404

申请日：2013-02-01

申请人： Council of Scientific and Industrial Research

发明人： Vidya Shrikant Gupta ,  Ram Shridhar Kulkarni ,  Ashok Prabhakar Giri ,  Keshav H. Pujari

IPC分类号： C12N9/02 ,  C12P17/04 ,  C12Q1/68

CPC分类号： C12P17/04 ,  C12N9/001 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Y103/01

摘要： Disclosed herein are primers for amplifying enone oxidoreductase, having a sequence selected from the group consisting of SEQ ID Nos. 1 to 13, from mango. Also disclosed herein is a nucleotide sequence of SEQ ID No. 14 encoding enone oxidoreductase, for enzyme production in an artificial system thus generating the desired flavor in food products.