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    Method for preparing 2′-O-fucosyllactose
    1.
    发明授权
    Method for preparing 2′-O-fucosyllactose 有权

    公开(公告)号：US11098075B2

    公开(公告)日：2021-08-24

    申请号：US15510268

    申请日：2015-09-11

    Applicant: BASF SE

    Inventor： Michael Puhl ,  Klaus Ditrich ,  Andreas Keller ,  Pepa Dimitrova ,  Melanie Weingarten ,  Wolfgang Siegel

    IPC: C07H15/26 ,  C07H3/06 ,  C07H1/00 ,  A23L33/10

    Abstract: The present invention relates to a method for preparing 2′-O-fucosyllactose, the 2′-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(═O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.

    GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN
    5.
    发明申请
    GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN 有权
    金丝桃素和羟基喹诺酮的生物合成基因组

    公开(公告)号：US20150275248A1

    公开(公告)日：2015-10-01

    申请号：US14441215

    申请日：2013-11-13

    Applicant: BASF SE

    Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schroeder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingrubber ,  Jakob Weber

    IPC: C12P17/04 ,  C12N15/80

    CPC classification number: C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

    Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

    Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

    HERBICIDAL ACTIVITY OF ALKYL PHOSPHINATES
    7.
    发明申请
    HERBICIDAL ACTIVITY OF ALKYL PHOSPHINATES 有权

    公开(公告)号：US20250049037A1

    公开(公告)日：2025-02-13

    申请号：US18717747

    申请日：2022-12-12

    Applicant: BASF SE

    Inventor： Klaus Ditrich ,  Michael Breuer ,  Moritz Stefan Pott ,  Gunther Zimmermann

    IPC: A01N57/20 ,  A01N57/24 ,  A01P13/02 ,  C07F9/32

    Abstract: The present invention relates to compounds of formula (I) and compositions comprising the same. The invention also relates to the use of compounds of formula (I), or of compositions comprising the same, or of compounds of formula (II), for controlling unwanted vegetation. Further, the invention relates to methods of applying compounds of formula (I), or compositions comprising the same, or compounds of formula (II) on plants, their seed and/or their habitat. Finally, the invention relates to a method of manufacturing a compound of formula (III) via a compound of formula (I).

    Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin
    9.
    发明申请
    Gene Cluster for Biosynthesis of Cornexistin and Hydroxycornexistin 有权
    用于生物合成Cornexistin和羟基角质素的基因簇

    公开(公告)号：US20140141440A1

    公开(公告)日：2014-05-22

    申请号：US14084030

    申请日：2013-11-19

    Applicant: BASF SE

    Inventor： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schröder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingruber ,  Jakob Weber

    IPC: C12P17/04

    CPC classification number: C12P17/04 ,  C12N15/52 ,  C12P7/50

    Abstract: The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

    Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

    METHODS FOR PREPARING L-GLUFOSINATE
    10.
    发明公开
    METHODS FOR PREPARING L-GLUFOSINATE 审中-公开

    公开(公告)号：US20240182502A1

    公开(公告)日：2024-06-06

    申请号：US18284108

    申请日：2022-03-30

    Applicant: BASF SE

    Inventor： Klaus Ditrich ,  Ana Escribano Cuesta

    IPC: C07F9/30 ,  C12P41/00

    CPC classification number: C07F9/301 ,  C12P41/006

    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) ammonium salt are provided. The methods comprise a refined multi-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. The third step involves the enrichment of the desired enantiomer in the yield by conversion of the obtained side product to the desired final product as well. By addition of the third refinement step, the proportion of the D-glufosinate present in a mixture of L-glufosinate and D-glufosinate can substantially be converted to the desired L-glufosinate ammonium salt.

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