METHODS FOR PREPARING L-GLUFOSINATE
    6.
    发明公开

    公开(公告)号:US20240182502A1

    公开(公告)日:2024-06-06

    申请号:US18284108

    申请日:2022-03-30

    Applicant: BASF SE

    CPC classification number: C07F9/301 C12P41/006

    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) ammonium salt are provided. The methods comprise a refined multi-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. The third step involves the enrichment of the desired enantiomer in the yield by conversion of the obtained side product to the desired final product as well. By addition of the third refinement step, the proportion of the D-glufosinate present in a mixture of L-glufosinate and D-glufosinate can substantially be converted to the desired L-glufosinate ammonium salt.

Patent Agency Ranking