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公开(公告)号：US09822385B2
公开(公告)日：2017-11-21
申请号：US14723776
申请日：2015-05-28
Applicant: AJINOMOTO CO., INC.
Inventor： Yoshihiko Hara , Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
IPC: C12P13/14 , C07K14/195 , C07K14/245 , C07K14/265 , C12P7/46 , C12P7/48 , C12P7/50 , C12P13/20
CPC classification number: C12P13/14 , C07K14/195 , C07K14/245 , C07K14/265 , C12P7/46 , C12P7/48 , C12P7/50 , C12P13/20
Abstract: An acidic substance having a carboxyl group is produced by culturing in a medium a microorganism which has been modified to enhance expression of the ybjL gene, and collecting the acidic substance having a carboxyl group from the medium.
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2.发明申请公开(公告)号：US20150322441A1
公开(公告)日：2015-11-12
申请号：US14717328
申请日：2015-05-20
Applicant: Celexion, LLC
Inventor： Brian M. Baynes , John Michael Geremia
CPC classification number: C12N15/70 , C12N15/77 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/50 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02
Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
Abstract translation: 本发明的方面涉及在宿主细胞中制备双功能烷烃的方法。 特别地，本发明的方面描述了与宿主细胞中碳水化合物原料的双官能烷烃生产相关的基因的组成部分。 更具体地，本发明的方面描述了通过2-酮基庚酸生产己二酸，氨基己酸，己内酰胺和六亚甲基二胺的代谢途径。
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公开(公告)号：US20150247170A1
公开(公告)日：2015-09-03
申请号：US14643788
申请日：2015-03-10
Applicant: Jianping YU , Troy PADDOCK , Damian CARRIERI , Pin-Ching MANESS , Michael SEIBERT
Inventor： Jianping YU , Troy PADDOCK , Damian CARRIERI , Pin-Ching MANESS , Michael SEIBERT
CPC classification number: C12P7/50 , C12N1/12 , C12N9/0069 , C12N15/63 , C12P5/026 , C12P7/40 , C12R1/01
Abstract: Strains of cyanobacteria that produce high levels of alpha ketoglutarate (AKG) and pyruvate are disclosed herein. Methods of culturing these cyanobacteria to produce AKG or pyruvate and recover AKG or pyruvate from the culture are also described herein. Nucleic acid sequences encoding polypeptides that function as ethylene-forming enzymes and their use in the production of ethylene are further disclosed herein. These nucleic acids may be expressed in hosts such as cyanobacteria, which in turn may be cultured to produce ethylene.
Abstract translation: 本文公开了产生高水平的α-酮戊二酸（AKG）和丙酮酸的蓝细菌菌株。 本文还描述了培养这些蓝细菌以产生AKG或丙酮酸并从培养物中回收AKG或丙酮酸的方法。 编码作为乙烯形成酶的多肽的核酸序列及其在乙烯生产中的用途在此进一步公开。 这些核酸可以在诸如蓝细菌的宿主中表达，其又可以培养以产生乙烯。
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公开(公告)号：US09057071B2
公开(公告)日：2015-06-16
申请号：US13876563
申请日：2013-01-31
Applicant: LanzaTech New Zealand Limited
Inventor： Michael Koepke , Shilpa Nagaraju , Wendy Yiting Chen
IPC: C12N1/12 , C12N1/20 , C12P7/06 , C12N15/74 , C12N15/00 , C12N15/52 , C12P7/40 , C12N9/88 , C12N9/04 , C12N9/10 , C12P7/46 , C12P7/48 , C12P7/50 , C12P7/56 , C12P13/06 , C12P13/08 , C12P7/42
CPC classification number: C12P7/065 , C12N1/20 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12N15/00 , C12N15/52 , C12N15/74 , C12N2510/02 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/50 , C12P7/56 , C12P13/06 , C12P13/08 , C12Y101/01004 , C12Y202/01006 , C12Y401/01005 , Y02E50/17
Abstract: The invention relates to methods for the production of chemical compounds, particularly but not exclusively ethanol, by microbial fermentation. Also described are genetically modified micro-organisms capable of using carbon monoxide to produce one or more products, particularly but not exclusively ethanol as a main product, and producing a reduced amount or substantially no 2,3-butanediol and/or a precursor thereof.
Abstract translation: 本发明涉及通过微生物发酵生产化合物，特别是但不限于乙醇的方法。 还描述了能够使用一氧化碳产生一种或多种产物，特别是但不限于乙醇作为主要产物，并且生产减少量或基本上不含2,3-丁二醇和/或其前体的经遗传修饰的微生物。
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5.发明申请公开(公告)号：US20140141440A1
公开(公告)日：2014-05-22
申请号：US14084030
申请日：2013-11-19
Applicant: BASF SE
Inventor： Oskar Zelder , Birgit Hoff , Hartwig Schröder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingruber , Jakob Weber
IPC: C12P17/04
Abstract: The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
Abstract translation: 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20120164702A1
公开(公告)日：2012-06-28
申请号：US13412277
申请日：2012-03-05
Applicant: Brian M. Baynes , John Michael Geremia
Inventor： Brian M. Baynes , John Michael Geremia
IPC: C12P7/44
CPC classification number: C12N15/70 , C12N15/77 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/50 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02
Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
Abstract translation: 本发明的方面涉及在宿主细胞中制备双功能烷烃的方法。 特别地，本发明的方面描述了与宿主细胞中碳水化合物原料的双官能烷烃生产相关的基因的组成部分。 更具体地，本发明的方面描述了通过2-酮基庚酸生产己二酸，氨基己酸，己内酰胺和六亚甲基二胺的代谢途径。
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7.发明申请NOVEL ALDOLASE AND PRODUCTION PROCESS OF SUBSTITUTED ALPHA-KETO ACIDS 失效新型ALDOLASE和替代ALPHA-KETO酸的生产方法公开(公告)号：US20120040416A1
公开(公告)日：2012-02-16
申请号：US13250359
申请日：2011-09-30
Applicant: Masakazu SUGIYAMA , Kunihiko Watanabe , Shigeru Kawahara
Inventor： Masakazu SUGIYAMA , Kunihiko Watanabe , Shigeru Kawahara
Abstract: 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
Abstract translation: 可用作合成莫纳甜的中间体的4-（吲哚-3-基甲基）-4-羟基-2-氧戊二酸，可以由吲哚丙酮酸和丙酮酸（和/或草酰乙酸）通过使用 衍生自假单胞菌属，欧文氏菌属，黄杆菌属或黄单胞菌属的新型醛缩酶。
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公开(公告)号：US20120028320A1
公开(公告)日：2012-02-02
申请号：US13255473
申请日：2010-03-11
Applicant: Petronella Catharina Raemakers-Franken , Martin Schürmann , Axel Christoph Trefzer , Stefaan Marie André De Wildeman
Inventor： Petronella Catharina Raemakers-Franken , Martin Schürmann , Axel Christoph Trefzer , Stefaan Marie André De Wildeman
CPC classification number: C12P7/50 , C12N9/0008 , C12N9/1025 , C12N9/88 , C12P7/44 , C12P13/005 , C12P13/02 , C12P17/10
Abstract: The invention relates to a method for preparing adipic acid, comprising converting alpha-ketoglutaric acid (AKG) into alpha-ketoadipic acid (AKA), converting alpha-ketoadipic acid into alpha-ketopimelic acid (AKP), converting alpha-ketopimelic acid into 5-formylpentanoic acid (5-FVA), and converting 5-formylpentanoic acid into adipic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst.The invention further relates to a heterologous cell, comprising one or more heterologous nucleic acid sequences encoding one or more heterologous enzymes capable of catalysing at least one reaction step in said method.
Abstract translation: 本发明涉及一种制备己二酸的方法，包括将α-酮戊二酸（AKG）转化为α-酮己二酸（AKA），将α-酮己二酸转化成α-酮戊二酸（AKP），将α-酮戊二酸转化为5 - 甲酰基戊酸（5-FVA），并将5-甲酰基戊酸转化成己二酸，其中这些转化中的至少一种使用异源生物催化剂进行。本发明还涉及异源细胞，其包含一个或多个异源核酸 编码能够在所述方法中催化至少一个反应步骤的一种或多种异源酶的序列。
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9.发明申请公开(公告)号：US20100151536A1
公开(公告)日：2010-06-17
申请号：US12637340
申请日：2009-12-14
Applicant: Brian M. Baynes , John Michael Geremia
Inventor： Brian M. Baynes , John Michael Geremia
CPC classification number: C12N15/70 , C12N15/77 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/50 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02
Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.
Abstract translation: 本发明的方面涉及在宿主细胞中制备双功能烷烃的方法。 特别地，本发明的方面描述了与宿主细胞中碳水化合物原料的双官能烷烃生产相关的基因的组成部分。 更具体地，本发明的方面描述了通过2-酮基庚酸生产己二酸，氨基己酸，己内酰胺和六亚甲基二胺的代谢途径。
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公开(公告)号：US20100112647A1
公开(公告)日：2010-05-06
申请号：US12579577
申请日：2009-10-15
Applicant: Yoshihiko Hara , Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
Inventor： Yoshihiko Hara , Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
IPC: C12P13/20 , C12N1/20 , C12N1/21 , C12P13/14 , C12P7/40 , C12P7/58 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/50
CPC classification number: C12P13/14 , C07K14/195 , C07K14/245 , C07K14/265 , C12P7/46 , C12P7/48 , C12P7/50 , C12P13/20
Abstract: An acidic substance having a carboxyl group is produced by culturing in a medium a microorganism which has been modified to enhance expression of the ybjL gene, and collecting the acidic substance having a carboxyl group from the medium.
Abstract translation: 具有羧基的酸性物质是通过在培养基中培养已被改良以增强ybjL基因表达的微生物，并从培养基中收集具有羧基的酸性物质产生的。
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