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公开(公告)号：US12104192B2
公开(公告)日：2024-10-01
申请号：US17194222
申请日：2021-03-06
Inventor： Sang Yup Lee , Dong In Kim , Tong Un Chae
CPC classification number: C12P13/08 , C12N9/88 , C12P13/001 , C12P13/06 , C12Y401/01014
Abstract: Disclosed is a method of preparing primary amines. More particularly, disclosed are a mutant microorganism transformed with a gene encoding a valine decarboxylase and a method of preparing primary amines from amino acids using the mutant microorganism. The method has an effect of synthesizing, in an environmentally friendly manner, primary amines as precursors for pharmaceuticals and agricultural chemicals using microorganisms, as an alternative to conventional chemical synthesis methods.
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2.发明公开
公开(公告)号：US20240110161A1
公开(公告)日：2024-04-04
申请号：US18266447
申请日：2021-12-08
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Kyungrim KIM , Jihyun SHIM , Heeyeong KIM , Woosung CHOI , Kwang Woo LEE
Abstract: The present application relates to a novel γ-aminobutyrate permease variant that decreases the amount of by-products generated during the production of L-isoleucine, a polynucleotide encoding the variant, and a vector comprising the polynucleotide, a microorganism comprising the variant, polynucleotide or vector, and a method for producing L-isoleucine using the microorganism.
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公开(公告)号：US11905539B2
公开(公告)日：2024-02-20
申请号：US17156998
申请日：2021-01-25
Applicant: CJ Cheiljedang Corporation
Inventor： Ji Hye Lee , Byeong Cheol Song , Ae Ji Jeon , Jong Hyun Kim , Hye Won Kim
CPC classification number: C12P13/06 , C12N9/1025 , C12N15/52 , C12N15/74 , C12N15/77 , C12Y203/03013
Abstract: A novel modified polypeptide having an isopropylmalate synthase activity, a polynucleotide encoding the same, a microorganism including the polypeptide, and a method of producing L-leucine by culturing the microorganism.
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公开(公告)号：US20230357808A1
公开(公告)日：2023-11-09
申请号：US18023960
申请日：2021-09-01
Applicant: METABOLIC EXPLORER
Inventor： Laurence DUMON-SEIGNOVERT , Céline RAYNAUD
CPC classification number: C12P13/06 , C12N9/0016 , C12Y104/01001
Abstract: The present invention relates to a microorganism genetically modified for improved production of alanine, wherein the microorganism expresses a heterologous alaD gene coding an alanine dehydrogenase and has reduced Lrp transcription factor activity and/or expression. The present invention also relates to a method for the production of alanine using said microorganism.
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5.发明公开
公开(公告)号：US20230340549A1
公开(公告)日：2023-10-26
申请号：US17787263
申请日：2020-12-18
Applicant: CJ CHEILJEDANG CORPORATION
Inventor： Seo Yun Kim , Seung Hyun Cho , Jae Min Lee , Min Ji Baek
CPC classification number: C12P13/06 , C12P13/12 , C12N15/77 , C12N9/1029 , C12Y203/01031 , C12N9/1085 , C12Y205/01049 , C12N9/1217 , C12Y207/02004 , C12N2800/101
Abstract: The present disclosure relates to a variant of YjeH, which is an inner membrane protein, a microorganism including the same, and a method for producing a target product using the same.
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公开(公告)号：US20190203240A1
公开(公告)日：2019-07-04
申请号：US16069302
申请日：2017-01-13
Applicant: Universitaet Hamburg
Inventor： Ulrich Rabausch , Henning Rosenfeld , Nele Ilmberger , Tanja Plambeck , Constantin Ruprecht , Friederike Boenisch
CPC classification number: C12P19/18 , C12P13/06 , C12P19/60 , C12Y204/01 , C12Y308/00
Abstract: A method for the production of rhamnosylated flavonoids comprising the steps of contacting/incubating a glycosyl transferase with a flavonoid and obtaining a rhamnosylated flavonoid. In addition, glycosyl transferases suitable for use in such methods and kits comprising said glycosyl transferases.
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公开(公告)号：US20190194769A1
公开(公告)日：2019-06-27
申请号：US16314953
申请日：2017-06-27
Applicant: Zymergen Inc.
Inventor： Shawn Manchester
IPC: C12R1/15 , C12N15/77 , C12P13/22 , C12P13/20 , C12P13/06 , C12P13/12 , C12P13/08 , C12P7/46 , C12P7/56 , C12P7/58 , C12P7/06 , C12P7/04
CPC classification number: C12R1/15 , C07K14/34 , C12N15/77 , C12P1/04 , C12P7/04 , C12P7/06 , C12P7/40 , C12P7/46 , C12P7/56 , C12P7/58 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227
Abstract: The present disclosure provides novel bacterial strains with altered expression or start codon modification of one or more RNA degradation/processing genes. The RNA degradation genes of the present disclosure are controlled by heterologous promoters. The present disclosure further describes methods for generating microbial strains comprising heterologous promoter sequences operably linked to RNA degradation/processing genes.
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8.发明申请
公开(公告)号：US20180346945A1
公开(公告)日：2018-12-06
申请号：US16054843
申请日：2018-08-03
Applicant: CODEXIS, INC.
Inventor： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC: C12P13/02 , C12P13/00 , C12P17/16 , C12P17/12 , C12P17/10 , C12P13/06 , C12P13/04 , C12P17/18 , C12N9/06
CPC classification number: C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号：US20180251772A1
公开(公告)日：2018-09-06
申请号：US15754903
申请日：2016-08-25
Applicant: CJ Cheiljedang Corporation
Inventor： Byeong Cheol Song , Ji Hye Lee , Ae Ji Jeon , Jong Hyun Kim , Hye Won Kim
Abstract: The present disclosure relates to a microorganism producing L-leucine and a method for producing L-leucine using the same, and more specifically, to a Corynebacterium glutamicum mutant which has resistance to L-leucine and a derivative thereof and improved L-leucine producing ability, and a method for producing L-leucine using the same.
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10.发明授权
公开(公告)号：US10066250B2
公开(公告)日：2018-09-04
申请号：US15899834
申请日：2018-02-20
Applicant: CODEXIS, INC.
Inventor： Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
IPC: C12P13/02 , C12N9/06 , C12P13/06 , C12P17/18 , C12P17/16 , C12P13/00 , C12P17/10 , C12P17/12 , C12P13/04
CPC classification number: C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
