公开(公告)号：US11757132B2

公开(公告)日：2023-09-12

申请号：US17735109

申请日：2022-05-02

申请人： SHENZHEN CAPCHEM TECHNOLOGY CO., LTD.

发明人： Qiao Shi ,  Muchong Lin ,  Shiguang Hu ,  Xionggui Lin ,  Jiaojiao Yun ,  Chang'an Zeng

IPC分类号： H01M10/0567 ,  H01M10/0525 ,  H01M10/0569 ,  H01M10/056 ,  C07D327/10 ,  C07D317/10 ,  C07F9/06 ,  C07F9/113

CPC分类号： H01M10/0567 ,  C07D317/10 ,  C07D327/10 ,  C07F9/062 ,  C07F9/113 ,  H01M10/056 ,  H01M10/0525 ,  H01M10/0569 ,  H01M2300/0037

摘要： A non-aqueous electrolyte for a lithium-ion battery and a lithium-ion battery. The non-aqueous electrolyte includes an unsaturated phosphate compound and a cyclic unsaturated carboxylic anhydride compound. The unsaturated phosphate compound has a structure represented by structural formula (4). R13, R11 and R12 are each independently selected from a hydrocarbon group having 1 to 5 carbon atoms, and at least one of R13, R11 and R12 is an unsaturated hydrocarbon group having a double bond or a triple bond. The unsaturated cyclic carboxylic anhydride compound having a structure represented by Structural Formula 5. R14 is selected from the group consisting of an alkenylene group having 2 to 4 carbon atoms or a fluorinated alkenylene group having 2 to 4 carbon atoms. By means of the synergistic effect of two compounds, the non-aqueous electrolyte has excellent high-temperature cycling performance and storage performance, and also has lower impedance and good low-temperature performance.

公开(公告)号：US10259834B2

公开(公告)日：2019-04-16

申请号：US15907352

申请日：2018-02-28

申请人： ENZYTECH. LTD.

发明人： Soon Ook Hwang ,  Dae Myoung Yun ,  Chang-min Kim

IPC分类号： C07F9/113 ,  C07B55/00

摘要： Racemic or optically active D- or L-α-glycerophosphoryl choline solids are prepared from liquid type racemic or optically active D- or L-α-glycerophosphoryl choline using an organic solvent. The solids are produced at a high yield more easily through phase transformation than an existing method using a difference in solubility in a solvent.

公开(公告)号：US20180273555A1

公开(公告)日：2018-09-27

申请号：US15907352

申请日：2018-02-28

申请人： ENZYTECH. LTD.

发明人： Soon Ook HWANG ,  Dae Myoung YUN ,  Chang-min KIM

IPC分类号： C07F9/113 ,  C07B55/00

CPC分类号： C07F9/113 ,  C07B55/00 ,  C07F9/091

摘要： Racemic or optically active D- or L-α-glycerophosphoryl choline solids are prepared from liquid type racemic or optically active D- or L-α-glycerophosphoryl choline using an organic solvent. The solids are produced at a high yield more easily through phase transformation than an existing method using a difference in solubility in a solvent.

公开(公告)号：US20170275311A1

公开(公告)日：2017-09-28

申请号：US15506174

申请日：2015-05-19

申请人： UBE INDUSTRIES, LTD.

发明人： Yuichi KOTOU ,  Tatsuo FUJINO ,  Kei SHIMAMOTO ,  Shuichi KOSO ,  Shoji SHIKITA ,  Yosuke SATO ,  Junichi CHIKA

IPC分类号： C07F9/113 ,  C07D207/444 ,  C07D309/32 ,  C07F9/12

CPC分类号： C07F9/113 ,  C07D207/444 ,  C07D309/32 ,  C07F1/02 ,  C07F9/11 ,  C07F9/117 ,  C07F9/12 ,  C07F9/17 ,  C07F9/173 ,  C07F9/18 ,  C07F9/3808 ,  C07F9/4028 ,  C07F9/4037 ,  C07F9/404 ,  C07F9/4065 ,  C07F9/4078 ,  C07F9/4084 ,  C07F9/5532 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6506 ,  C07F9/6512 ,  C07F9/653 ,  C07F9/6551 ,  C07F9/65515 ,  C07F9/6552 ,  H01G11/06 ,  H01G11/64 ,  H01M6/168 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/0569 ,  Y02E60/13 ,  Y02T10/7011 ,  Y02T10/7022

摘要： The present invention is concerned with a nonaqueous electrolytic solution having an electrolyte salt dissolved in a nonaqueous solvent, the nonaqueous electrolytic solution containing a compound represented by the following general formula (X), in which a polar group (X) is bound to a phosphorus atom (P), and capable of improving electrochemical characteristics in a broad temperature range; an energy storage device using the same; and a novel compound. In the formula, R10 and R20 are each independently an organic group selected from the group consisting of an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an alkynyl group having 3 to 6 carbon atoms, and an aryl group having 6 to 12 carbon atoms, or a lithium atom; and X is a polar group (i) containing a —C(═O) group, a —P(═O) group, or an —S(═O)2 group, a polar group (ii) containing a —CN group or an alkyl group having 1 to 6 carbon atoms, in which a part of hydrogen atoms is substituted with a fluorine atom, or a 4- to 7-membered ring polar group (iii) containing a —C(═O)—O— group or a —C(═O)—N— group, provided that when X is a 4- to 7-membered ring polar group (iii) containing a —C(═O)—N— group, at least one of R10 and R20 is a lithium atom.

公开(公告)号：US09133222B2

公开(公告)日：2015-09-15

申请号：US13982977

申请日：2011-12-28

申请人： Leonid Leonidovich Danilov

发明人： Leonid Leonidovich Danilov

IPC分类号： C08J11/08 ,  C07F9/06 ,  C07F9/113

CPC分类号： C07F9/06 ,  C07F9/113

摘要： Method produces polyprenyl phosphates of formula, where each isoprene unit contains 5 carbon atoms, W is ω-end isoprene, T is trans-isoprene, C is cis-isoprene, S is 2,3-dihydroisoprene, a=0-10, b=0-39, c=0-1, a+b+c=4-40, and X is of formula OPO3MM′, wherein M and M′ are identical or different and are a hydrogen cation or monovalent inorganic or organic cation, or M and M′ together are divalent inorganic or organic cation, the phosphorylation of the relevant polyprenol or a mixture of oligomer homologues, where X is hydroxyl group, using a substituted ammonium salt of phosphoric acid in presence of condensing agent, is carried out in a medium of first aprotic organic solvent; and a polyprenyl phosphate of mono- or disubstituted salts thereof with monovalent cations or in form of salts thereof with divalent cations is isolated by extraction and precipitation.

摘要翻译： 方法产生具有下式的聚异戊二烯基磷酸酯，其中每个异戊二烯单元含有5个碳原子，W是ω-末端异戊二烯，T是异戊二烯，C是顺式 - 异戊二烯，S是2,3-二氢异戊二烯，a = 0-10，b = 0-39，c = 0-1，a + b + c = 4-40，X为式OPO3MM'，其中M和M'相同或不同，为氢阳离子或一价无机或有机阳离子， 或M和M'是二价无机或有机阳离子，在缩合剂存在下，使用磷酸的取代铵盐在缩合剂存在下磷酸化相关聚异戊二醇或其中X为羟基的低聚物同系物的混合物进行 第一种非质子有机溶剂的介质; 并且通过萃取和沉淀来分离其与一价阳离子或其与二价阳离子的盐形式的一或二取代的盐的聚磷酸酯。

公开(公告)号：US20120225020A1

公开(公告)日：2012-09-06

申请号：US13405074

申请日：2012-02-24

申请人： Eduard Y. Chekmenev ,  Roman V. Shchepin

发明人： Eduard Y. Chekmenev ,  Roman V. Shchepin

IPC分类号： A61K49/06 ,  C07F9/113 ,  C07F7/04 ,  C07F7/02 ,  C07F7/18 ,  C07C219/20 ,  C07C67/00

CPC分类号： C07C221/00 ,  A61K49/10 ,  C07B59/001 ,  C07B2200/05 ,  C07C219/20 ,  C07F9/113 ,  Y02P20/55

摘要： This disclosure provides choline analogs comprising the following structure: where each R1 independently is H or isotopically enriched D, R2 is a protecting group, and N is 14N or isotopically enriched 15N. This disclosure also provides methods of making choline analogs, which include performing a protection step on a betaine aldehyde to form a choline analog, and methods of using choline analogs to form hyperpolarized compounds.

摘要翻译： 本公开提供了包含以下结构的胆碱类似物：其中每个R 1独立地是H或同位素富集D，R 2是保护基，N是14N或同位素富集15N。 本公开还提供了制备胆碱类似物的方法，其包括对甜菜碱醛进行保护步骤以形成胆碱类似物，以及使用胆碱类似物形成超极化化合物的方法。

公开(公告)号：US08207367B2

公开(公告)日：2012-06-26

申请号：US12159332

申请日：2006-12-26

申请人： Minoru Kurata ,  Keishi Shimokawa

发明人： Minoru Kurata ,  Keishi Shimokawa

IPC分类号： C07F9/113

CPC分类号： C08F230/02 ,  C07F9/091 ,  C07F9/098

摘要： The present invention relates to a method of producing a polymerizable phosphate containing at least one selected from polymerizable phosphates represented by formula (II), (III) or (IV) by a batch reaction, including a step of adding a compound represented by formula (I) into a mixture of a polymerizable phosphate reaction product containing at least one selected from polymerizable phosphates represented by formula (II), (III) or (IV), obtained by a pre-batch reaction, and phosphoric acid anhydride to react them: wherein R1 represents H or a C1-4 alkyl group, R2 represents a C2-6 alkylene group and n denotes an integer from 1 to 3.

摘要翻译： 本发明涉及通过间歇反应制备含有选自式（II），（III）或（IV）表示的可聚合磷酸酯中的至少一种的可聚合磷酸酯的方法，包括将式（II） I）转化成含有选自由分批间反应得到的式（II），（III）或（IV）表示的可聚合磷酸酯的至少一种的可聚合磷酸酯反应产物和磷酸酐反应的混合物： 其中R1表示H或C1-4烷基，R2表示C2-6亚烷基，n表示1至3的整数。

公开(公告)号：US08093229B2

公开(公告)日：2012-01-10

申请号：US12471298

申请日：2009-05-22

申请人： Srinivas Rao Kasibhatla ,  Marco Antonio Biamonte ,  Jiandong Shi ,  Marcus F. Boehm

发明人： Srinivas Rao Kasibhatla ,  Marco Antonio Biamonte ,  Jiandong Shi ,  Marcus F. Boehm

IPC分类号： A61K31/519 ,  A61K31/661 ,  A61P35/00 ,  C07F9/113 ,  C07D487/04

CPC分类号： C07D487/02 ,  C07D487/04

摘要： Alkynyl pyrrolo [2,3-d] pyrimidines of Formula I are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.

摘要翻译： 描述了式I的炔基吡咯并[2,3-d]嘧啶，并证明其可用作用于治疗和预防各种HSP90介导的病症的热休克蛋白90（HSP90）抑制剂。 还描述和要求保护这些化合物的合成和使用方法。

公开(公告)号：US20110230449A1

公开(公告)日：2011-09-22

申请号：US12671802

申请日：2008-07-29

申请人： Peter Klug ,  Franz-Xaver Scherl ,  Waltraud Simsch ,  Adelgunde Oberhauser

发明人： Peter Klug ,  Franz-Xaver Scherl ,  Waltraud Simsch ,  Adelgunde Oberhauser

IPC分类号： A61K8/55 ,  C07F9/113 ,  A61P19/00

CPC分类号： A61Q19/00 ,  A61K8/86 ,  C07F9/091 ,  C08G65/327

摘要： The invention relates to alkoxylated phosphoric acid triesters of formula (I) wherein x, y and z respectively stand for a number between 51 and 200. The alkoxylated phosphoric acid triesters of formula (I) are characterised especially by advantageous thickening properties.

摘要翻译： 本发明涉及式（I）的烷氧基​​化磷酸三酯，其中x，y和z分别代表51到200之间的数字。式（I）的烷氧基​​化磷酸三酯的特征特别是有利的增稠性质。

公开(公告)号：US20050043534A1

公开(公告)日：2005-02-24

申请号：US10483618

申请日：2002-07-11

申请人： Alicja Bielawska ,  Yusuf Hannun ,  Zdzislaw Szulc ,  Julnar Usta ,  Samer El Bawab

发明人： Alicja Bielawska ,  Yusuf Hannun ,  Zdzislaw Szulc ,  Julnar Usta ,  Samer El Bawab

IPC分类号： A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07C215/24 ,  C07C217/46 ,  C07C233/18 ,  C07C275/20 ,  C07F9/113 ,  C07C231/02 ,  C07D207/46 ,  C07D209/18

CPC分类号： C07C275/20 ,  C07C215/24 ,  C07C217/46 ,  C07C233/18 ,  C07F9/113

摘要： The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as methods screening for compounds that inhibit mitochondrial ceramidase. The invention also relates to the use of the compounds as a regulator of the level of ceramide by inhibiting ceramidase activity. The invention also relates to methods for the prevention and treatment of diseases associated with cell overproliferation and sphingolipid signal transduction including cancer, cardiovascular diseases, and inflammation.

摘要翻译： 本发明涉及可用作线粒体神经酰胺酶，特别是人线粒体神经酰胺酶的抑制剂的化合物。 本发明还涉及设计和制备化合物的方法，以及筛选抑制线粒体神经酰胺酶的化合物的方法。 本发明还涉及通过抑制神经酰胺酶活性将化合物用作神经酰胺水平的调节剂的用途。 本发明还涉及预防和治疗与细胞过度增殖和鞘脂信号转导相关的疾病的方法，包括癌症，心血管疾病和炎症。