公开(公告)号：US20180105503A1

公开(公告)日：2018-04-19

申请号：US15689168

申请日：2017-08-29

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Melissa Fleury ,  Roland Gendron ,  Adam D. Hughes ,  Jane Schmidt

IPC分类号： C07D261/18 ,  A61K45/06 ,  A61K31/42

CPC分类号： C07D261/18 ,  A01N47/16 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4355 ,  A61K31/437 ,  A61K45/06 ,  A61K47/55 ,  A61K47/6895 ,  C07D213/81 ,  C07D237/04 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D249/18 ,  C07D263/34 ,  C07D307/68 ,  C07D333/38 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C09K15/30

摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US09771337B2

公开(公告)日：2017-09-26

申请号：US15289356

申请日：2016-10-10

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Melissa Fleury ,  Roland Gendron ,  Adam D. Hughes ,  Jane Schmidt

IPC分类号： A61K31/42 ,  C07D261/18 ,  A61K45/06 ,  A61K47/48 ,  A61K31/437 ,  A61K31/4355 ,  A01N47/16 ,  C09K15/30 ,  C07D213/81 ,  C07D237/04 ,  A61K31/4196

CPC分类号： C07D261/18 ,  A01N47/16 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4355 ,  A61K31/437 ,  A61K45/06 ,  A61K47/55 ,  A61K47/6895 ,  C07D213/81 ,  C07D237/04 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D249/18 ,  C07D263/34 ,  C07D307/68 ,  C07D333/38 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C09K15/30

摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US20170088526A1

公开(公告)日：2017-03-30

申请号：US15289356

申请日：2016-10-10

申请人： THERAVANCE BIOPHARMA R&D IP, LLC

发明人： Melissa Fleury ,  Roland Gendron ,  Adam D. Hughes ,  Jane Schmidt

IPC分类号： C07D261/18 ,  A61K31/42 ,  A61K45/06

CPC分类号： C07D261/18 ,  A01N47/16 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4355 ,  A61K31/437 ,  A61K45/06 ,  A61K47/55 ,  A61K47/6895 ,  C07D213/81 ,  C07D237/04 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D249/18 ,  C07D263/34 ,  C07D307/68 ,  C07D333/38 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C09K15/30

摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.