- 专利标题： Inhibitors of Mcl-1 as Drugs to Overcome Resistance to BRAF Inhibitors and MEK Inhibitors
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申请号： US15580991申请日： 2016-06-06
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公开(公告)号： US20180161313A1公开(公告)日： 2018-06-14
- 发明人: Sanjay K. Srivastava , Neel M. Fofaria
- 申请人： Texas Tech University System
- 国际申请： PCT/US16/36002 WO 20160606
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; A61K31/445 ; A61K31/40 ; A61K31/4196 ; A61K31/4025 ; A61K31/538 ; A61K31/165 ; A61K31/5415 ; A61K31/4709 ; A61K31/4178 ; A61K31/405 ; A61K31/433 ; A61K31/5377 ; A61K31/47 ; A61K31/423 ; A61K31/4439 ; A61K31/4965 ; A61K31/501 ; A61K31/444 ; A61K31/4245 ; A61K31/496 ; A61K31/4525 ; A61K31/541 ; A61K31/341 ; A61K31/519 ; A61K31/437 ; A61K31/506 ; A61P35/00 ; G01N33/50
摘要：
The present invention includes compositions and methods for inhibiting MCL-1, including novel inhibitors of MCL-1, and compositions and methods for treating a subject with cancer that is refractory to one or more MAPK pathway protein inhibitors.
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