公开(公告)号：US20240325335A1

公开(公告)日：2024-10-03

申请号：US18616966

申请日：2024-03-26

申请人： Alexander E. Michalow ,  Andrew Michalow

发明人： Alexander E. Michalow ,  Andrew Michalow

IPC分类号： A61K31/20 ,  A61K9/00 ,  A61K31/7012 ,  A61K47/54 ,  A61K47/69 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

CPC分类号： A61K31/20 ,  A61K9/0014 ,  A61K9/006 ,  A61K9/0078 ,  A61K31/7012 ,  A61K47/544 ,  A61K47/547 ,  A61K47/6951 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

摘要： A topical aqueous antibiofilm, antimicrobial, and antiviral composition to disrupt biofilm to enhance the killing of microbial and viral particles in a way that prevents and reduces the severity of conditions and infections that are due to such microbial pathogens and viral particles is provided. The composition comprises a fatty acid chosen from saturated and/or unsaturated medium chain fatty acids (MCFAs: C-8 to C-12), saturated and/or unsaturated long chain fatty acids (LCFAs: C-13 to C-26), and/or their derivatives, salts, sugars and esters. The composition also comprises a solubilizing agent, preferably a cyclodextrin, which additionally synergizes the antibiofilm effect, and may be formulated for nebulization/inhalation. The composition further comprises chelating and enhancing agents, and either a neutral, acid or alkaline pH. The composition comprises skin and mucosal permeation enhancers, which improve clinical efficacy. The composition comprises additional antimicrobial and antiviral compounds that can optionally be applied concomitantly.