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    Method for preparing benzyl amine compound
    1.
    发明授权
    Method for preparing benzyl amine compound 有权

    公开(公告)号：US11873265B2

    公开(公告)日：2024-01-16

    申请号：US17239500

    申请日：2021-04-23

    申请人： SOOCHOW UNIVERSITY

    发明人： Hongmei Sun ,  Dan Wang

    IPC分类号： C07D231/56 ,  C07C209/02 ,  B01J31/22 ,  C07C211/48

    CPC分类号： C07C209/02 ,  B01J31/22 ,  C07C211/48

    摘要： Disclosed is a method for preparing a benzyl amine compound, i.e., synthesizing a benzyl amine compound by means of an oxidation reaction between a methylbenzene/ethylbenzene compound and arylamine by using an ionic iron (III) complex containing 1,3-di-tert-butylimidazolium cation and having a molecular formula of [(RNCHCHNR)CH][FeBr4] (R being tert-butyl) and di-t-butyl peroxide as an oxidant. The present invention is not only applicable to a methylbenzene compound containing a benzylic primary carbon-hydrogen bond but also applicable to an ethylbenzene compound containing a benzylic secondary carbon-hydrogen bond, and therefore is widely applicable. This is the first case where the preparation of a benzyl amine compound by means of an oxidation reaction between a methylbenzene/ethylbenzene compound and arylamine is implemented by an iron catalyst.

    Compositions and methods for glucose transport inhibition
    3.
    发明授权
    Compositions and methods for glucose transport inhibition 有权

    公开(公告)号：US11072576B2

    公开(公告)日：2021-07-27

    申请号：US16522314

    申请日：2019-07-25

    申请人： OHIO UNIVERSITY

    发明人： Xiaozhuo Chen ,  Stephen Bergmeier

    IPC分类号： C07C205/32 ,  C07C211/48 ,  C07C39/367 ,  C07C43/23 ,  C07C235/56 ,  C07C43/253 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D319/20 ,  A61K31/09 ,  C07D311/16 ,  C07D311/82 ,  A61K45/06

    摘要： Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.