公开(公告)号：US11964261B2

公开(公告)日：2024-04-23

申请号：US17324034

申请日：2021-05-18

申请人： Xiangtan University

发明人： Jicheng Zhou ,  Yanji Zhang ,  Fei Wang

IPC分类号： B01J29/03 ,  B01J37/02 ,  B01J37/08 ,  B01J37/34 ,  C07C209/36 ,  C07C211/52

CPC分类号： B01J29/0325 ,  B01J37/0228 ,  B01J37/0236 ,  B01J37/0244 ,  B01J37/088 ,  B01J37/343 ,  B01J37/345 ,  C07C209/365 ,  C07C211/52 ,  C07C209/365 ,  C07C211/52

摘要： A catalyst including platinum (Pt) and a composite support. The composite support includes ZrO2/mesoporous silica sieve SBA-15. The platinum accounts for 0.01-0.3 wt. % of the catalyst. ZrO2 accounts for 5-20 wt. % of the composite support.

公开(公告)号：US11691943B2

公开(公告)日：2023-07-04

申请号：US17686997

申请日：2022-03-04

申请人： JIANGXI TIANYU CHEMICAL CO., LTD.

发明人： Chaoqun Huang ,  Jintao Zhu ,  Liangming Luo ,  Rong Zhang

IPC分类号： C07C209/74 ,  B01J31/02 ,  C07C209/86 ,  C07C211/52

CPC分类号： C07C209/74 ,  B01J31/0239 ,  C07C209/86 ,  C07C211/52

摘要： The present disclosure provides a preparation method of 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline and an application thereof. The preparation method comprises the following steps: reacting 2-aminobenzotrifluoride and 2-bromoheptafluoropropane in the presence of sodium formate or hydrates thereof and a SO2 reagent, so as to obtain 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline. The present disclosure adds sodium formate or hydrate thereof and the SO2 reagent during the reaction of 2-aminobenzotrifluoride and 2-bromoheptafluoropropane. Under the cooperation of these two compounds, the yield of the reaction is high. And the purity of the product is high, the operation method is simple, the cost is relatively low, and the pH of the reaction doesn't need to be controlled.

公开(公告)号：US11572368B2

公开(公告)日：2023-02-07

申请号：US15234675

申请日：2016-08-11

申请人： The General Hospital Corporation ,  The Broad Institute, Inc. ,  Massachusetts Institute of Technology

发明人： Edward Holson ,  Florence Fevrier Wagner ,  Michel Weiwer ,  Li-Huei Tsai ,  Stephen J. Haggarty ,  Yan-Ling Zhang

IPC分类号： C07D491/107 ,  C07D401/12 ,  C07D403/12 ,  C07D309/08 ,  C07D311/82 ,  C07D333/20 ,  C07D405/12 ,  C07D493/08 ,  C07D211/22 ,  C07D213/40 ,  C07C271/28 ,  C07C275/30 ,  C07C275/40 ,  C07C281/06 ,  C07C211/52 ,  C07C233/43 ,  C07C233/56 ,  C07C233/62 ,  C07C235/82 ,  C07D409/12 ,  C07C237/20 ,  C07D205/06 ,  C07D213/56 ,  C07D241/12 ,  C07D333/24 ,  C07C237/24 ,  C07D205/04 ,  C07D209/44 ,  C07D209/52 ,  C07D211/34 ,  C07D211/62 ,  C07D295/195 ,  C07D471/04 ,  A61K31/167 ,  A61K31/402 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/437 ,  A61K31/445 ,  A61K31/351 ,  A61K31/352 ,  A61K31/381 ,  A61K31/397 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/439 ,  A61K31/4418 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  C07C233/42 ,  C07D231/04 ,  C07D237/04 ,  C07D295/185 ,  C07D311/04 ,  C07D407/12 ,  C07D487/04 ,  C07D487/10 ,  C07D491/08

摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

公开(公告)号：US20220105462A1

公开(公告)日：2022-04-07

申请号：US17553807

申请日：2021-12-17

申请人： FUJIFILM Corporation

发明人： Koji HIRONAKA

IPC分类号： B01D53/22 ,  B01D71/64 ,  B01D69/10 ,  B01D69/12 ,  B01D71/42 ,  B01D69/02 ,  C07C211/52 ,  C08G73/10 ,  C10L3/10

摘要： Provided are a compound represented by formula (Ia) below, a polymer obtained by using the compound as a synthesis raw material, a gas separation membrane having a gas separation layer including the polymer, and a gas separation module and a gas separation apparatus that have the gas separation membrane. RA and RB represent a hydrogen atom, an alkyl group, or a halogen atom.
LA represents —CF2—, —CF(CF3)—, —C(═O)—, —CH2—, —CH(CH3)—, or —CH(CF3)— or a group obtained by combining the foregoing groups. LA has 4 or less carbon atoms.

公开(公告)号：US11208377B2

公开(公告)日：2021-12-28

申请号：US16103607

申请日：2018-08-14

申请人： ALLERGAN, INC.

发明人： Christopher D. Hein ,  Tien T. Duong ,  Santosh Sinha ,  Ling Li ,  Jeremiah H. Nguyen ,  David W. Old ,  Robert Burk ,  Veena Viswanath ,  Sandhya Rao ,  John E. Donello

IPC分类号： C07C311/39 ,  A61P17/06 ,  C07C237/44 ,  A61P27/02 ,  C07C211/52 ,  C07D307/36 ,  C07D307/79 ,  C07D215/42 ,  C07B59/00 ,  C07D333/54 ,  C07C311/43 ,  A61P29/00

摘要： Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.

公开(公告)号：US20210268485A1

公开(公告)日：2021-09-02

申请号：US17324034

申请日：2021-05-18

申请人： Xiangtan University

发明人： Jicheng ZHOU ,  Yanji ZHANG ,  Fei WANG

IPC分类号： B01J29/03 ,  B01J37/02 ,  B01J37/08 ,  B01J37/34 ,  C07C209/36 ,  C07C211/52

摘要： A catalyst including platinum (Pt) and a composite support. The composite support includes ZrO2/mesoporous silica sieve SBA-15. The platinum accounts for 0.01-0.3 wt. % of the catalyst. ZrO2 accounts for 5-20 wt. % of the composite support.

公开(公告)号：US20200216448A1

公开(公告)日：2020-07-09

申请号：US16735479

申请日：2020-01-06

申请人： CORNELL UNIVERSITY ,  ITHACA COLLEGE

发明人： Richard CERIONE ,  Kristin CERIONE ,  Clint STALNECKER ,  Scott ULRICH

IPC分类号： C07D471/04 ,  C07D221/18 ,  C07D207/16 ,  C07D277/82 ,  C07D295/135 ,  C07C211/58 ,  C07C217/90 ,  C07C237/40 ,  C07D221/06 ,  C07D401/10 ,  C07C311/37 ,  C07C211/49 ,  C07C211/52 ,  C07D233/61 ,  C07C211/59 ,  C07C311/21 ,  C07D221/04 ,  C07D221/12 ,  C12N9/80 ,  C12N9/96 ,  C12Q1/34

摘要： The present invention relates generally to glutaminase inhibitors of Formula I, Formula II, or Formula III, as well as pharmaceutical compounds containing them and methods of their use.

公开(公告)号：US10526322B2

公开(公告)日：2020-01-07

申请号：US15533198

申请日：2015-12-05

申请人： CORNELL UNIVERSITY ,  ITHACA COLLEGE

发明人： Richard Cerione ,  Kristin Cerione ,  Clint Stalnecker ,  Scott Ulrich

IPC分类号： C07D471/04 ,  C07D207/16 ,  C07D221/04 ,  C07D221/06 ,  C07D221/12 ,  C07D221/18 ,  C07D233/61 ,  C07D277/82 ,  C07D295/135 ,  C07D401/10 ,  C07C211/49 ,  C07C211/42 ,  C07C211/58 ,  C07C211/59 ,  C07C237/40 ,  C07C311/21 ,  C07C311/37 ,  C12N9/80 ,  C12N9/96 ,  C12Q1/34 ,  C07C211/52 ,  C07C217/90

摘要： The present invention relates generally to glutaminase inhibitors of Formula I, Formula II, or Formula III, as well as pharmaceutical compounds containing them and methods of their use.

公开(公告)号：US20200000777A1

公开(公告)日：2020-01-02

申请号：US16508818

申请日：2019-07-11

申请人： Takeshi MITA ,  Takamasa KIKUCHI ,  Takashi MIZUKOSHI ,  Manabu YAOSAKA ,  Mitsuaki KOMODA ,  Shinji TAKII

发明人： Takeshi MITA ,  Takamasa KIKUCHI ,  Takashi MIZUKOSHI ,  Manabu YAOSAKA ,  Mitsuaki KOMODA ,  Shinji TAKII

IPC分类号： A61K31/421 ,  C07C25/13 ,  C07C25/24 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  A01N43/80 ,  C07C43/174 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/16 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F7/08 ,  C07D413/04 ,  C07D261/04 ,  C07D413/14 ,  A61K9/00

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

公开(公告)号：US20180318266A1

公开(公告)日：2018-11-08

申请号：US15972939

申请日：2018-05-07

申请人： NISSAN CHEMICAL INDUSTRIES, LTD.

发明人： Takeshi MITA ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda ,  Shinji Takii

IPC分类号： A61K31/421 ,  C07C25/08 ,  A01N43/80 ,  C07C25/02 ,  C07C25/24 ,  C07C25/13 ,  A61K9/00 ,  C07D413/14 ,  C07D261/04 ,  C07F7/08 ,  C07D417/12 ,  C07D417/06 ,  C07D413/12 ,  C07D413/06 ,  C07D413/04 ,  C07D261/16 ,  C07C323/09 ,  C07C281/02 ,  C07C255/60 ,  C07C255/50 ,  C07C255/29 ,  C07C251/48 ,  C07C211/52 ,  C07C205/12 ,  C07C205/11 ,  C07C43/174 ,  C07C25/06

摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1 is a fluorine atom, chlorine atom or trifluoromethyl, and both X2 and X3 are a hydrogen atom, in case where both X1 and X2 are fluorine atom and X3 is a hydrogen atom, and in case where both X1 and X2 are trifluoromethyl and X3 is a hydrogen atom, R3c is a hydrogen atom, chlorine atom, bromine atom, iodine atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.