公开(公告)号：US10647654B2

公开(公告)日：2020-05-12

申请号：US16311417

申请日：2017-06-23

申请人： OHIO UNIVERSITY

发明人： Stephen Bergmeier ,  Xiaozhuo Chen

IPC分类号： C07C63/33 ,  C07C39/15 ,  C07C63/331 ,  A61P35/00

摘要： Compounds that inhibit or reduce glucose transport and methods of using the compounds to treat cancer are provided herein.

公开(公告)号：US10385005B2

公开(公告)日：2019-08-20

申请号：US15995645

申请日：2018-06-01

申请人： OHIO UNIVERSITY

发明人： Xiaozhuo Chen ,  Stephen Bergmeier

IPC分类号： C07C205/32 ,  C07C211/48 ,  C07C39/367 ,  C07C43/23 ,  C07C235/56 ,  C07C43/253 ,  A61K31/09 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D319/20 ,  C07D311/16 ,  C07D311/82 ,  A61K45/06 ,  A61K31/166

摘要： Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.

公开(公告)号：US11072576B2

公开(公告)日：2021-07-27

申请号：US16522314

申请日：2019-07-25

申请人： OHIO UNIVERSITY

发明人： Xiaozhuo Chen ,  Stephen Bergmeier

IPC分类号： C07C205/32 ,  C07C211/48 ,  C07C39/367 ,  C07C43/23 ,  C07C235/56 ,  C07C43/253 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D319/20 ,  A61K31/09 ,  C07D311/16 ,  C07D311/82 ,  A61K45/06

摘要： Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.

公开(公告)号：US10000443B2

公开(公告)日：2018-06-19

申请号：US14935902

申请日：2015-11-09

申请人： OHIO UNIVERSITY

发明人： Xiaozhuo Chen ,  Stephen Bergmeier

IPC分类号： C07C205/32 ,  C07C211/48 ,  C07C39/367 ,  C07C43/23 ,  C07C235/56 ,  C07C43/253 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D319/20 ,  C07D311/16 ,  C07D311/82 ,  A61K31/09 ,  A61K45/06

CPC分类号： C07C205/32 ,  A61K31/09 ,  A61K45/06 ,  C07C39/367 ,  C07C43/23 ,  C07C43/253 ,  C07C211/48 ,  C07C235/56 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D311/16 ,  C07D311/82 ,  C07D319/20

摘要： Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.