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公开(公告)号：US20170361310A1
公开(公告)日：2017-12-21
申请号：US15469654
申请日：2017-03-27
发明人： Radhey S. SRIVASTAVA , Siva Murru
CPC分类号： B01J31/2217 , B01J31/183 , B01J2231/44 , B01J2531/16 , C07B2200/07 , C07C209/02 , C07C211/56 , C07C211/58 , C07C227/32 , C07F1/005 , C07C211/48 , C07C229/18
摘要： The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding allylic substrates and substituted hydroxylamines, in the presence of a catalyst, said catalyst comprising copper compounds and a chiral ligand. Examples of chiral amine compounds which can be made using the method include Vigabatrin, Ezetimibe Terbinafine, Naftifine 3-methylmorphine, Sertraline, Cinacalcet, Mefloquine hydrochloride, and Rivastigmine. There are over 20,000 known bioactive molecules with chiral N-substituted allylic amine substructure. The method may also be used to produce non-natural chiral β-aminoacid esters, a sub-class of chiral N-substituted allylic amine compounds. Examples of β-aminoacid ester which can be produced by the disclosed method, include, but are not limited to, N-(2-methylpent-1-en-3-yl)benzenamine and Ethyl 2-methylene-3-(phenylamino)butanoate. Further, the products of the method described herein can be used to produce chiral heterocycles and bioactive molecules or materials. A novel chiral copper-ligand nitrosoarene complex is also set forth.
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2.发明授权公开(公告)号：US09783486B2
公开(公告)日：2017-10-10
申请号：US15038984
申请日：2014-11-24
发明人： Stephen W. King , Sadeka Onam
IPC分类号： C07C211/14 , C07C209/02 , C08G73/02 , C07C209/64 , B01J23/889
CPC分类号： C07C211/14 , B01J23/8896 , C07C209/02 , C07C209/64 , C08G73/0206 , C08G73/0213
摘要： A process for preparing high molecular weight, branched, acyclic polyalkyleneamines comprising transaminating a reaction mixture that includes at least a first polyalkyleneamine component that contains at least two non-tertiary amine groups separated from one another by a ternary or higher carbon atom and a second polyalkyleneamine component having the formula wherein x, y, and z are the same or different and are integers of from 1 to 10; a, b, c, d, e, and f are the same or different and are H or hydrocarbyl of from 1 to 10 carbon atoms; A, B, C, D, E, are the same or different and are H or hydrocarbyl of from 1 to 10 carbon atoms; provided that at least two of the amine groups are primary or secondary.
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3.发明申请BIS(PHOSPHINE)-CARBODICARBENE CATALYST COMPLEXES AND METHODS OF USING THE SAME 审中-公开BIS（PHOSPHINE） - 碳酸二苯酯催化剂复合物及其使用方法公开(公告)号：US20170029453A1
公开(公告)日：2017-02-02
申请号：US15302699
申请日：2015-04-14
IPC分类号： C07F15/00 , B01J31/22 , C07F9/6561 , C07D295/145 , C07C213/08 , C07D295/03 , C07C227/08 , C07D207/46 , B01J31/24 , C07C209/02
CPC分类号： C07F15/0073 , B01J31/2273 , B01J31/2409 , B01J31/2452 , B01J2231/32 , B01J2231/321 , B01J2531/0244 , B01J2531/822 , C07C209/02 , C07C213/08 , C07C227/08 , C07C2601/14 , C07C2601/16 , C07D207/04 , C07D207/46 , C07D207/48 , C07D295/03 , C07D295/145 , C07D295/15 , C07F9/6561 , C07C229/30 , C07C211/48 , C07C211/52 , C07C211/27 , C07C211/28 , C07C217/84 , C07C215/24
摘要： An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the structure of Formula (I): The complexes are useful in methods of making an allylic amine carried out by reacting a 1,3-diene with a substituted amine in the presence of such an organometallic complex to produce by intermolecular hydroamination the allylic amine.
摘要翻译： 描述了三齿双（膦） - 碳二碳烯配体和过渡金属的有机金属络合物。 在一些实施方案中，配体具有式（I）的结构：该复合物可用于通过在这种有机金属络合物的存在下使1,3-二烯与取代的胺反应来制备烯丙基胺的方法，以通过 分子间水解烯丙基胺。
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4.发明申请SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER 有权使用铁催化硝基转移合成环状和环状氨基公开(公告)号：US20160002145A1
公开(公告)日：2016-01-07
申请号：US14770217
申请日：2014-02-26
IPC分类号： C07C209/02 , C07D207/16 , C07F15/02 , C07D209/54 , C07D211/16 , C07D205/04 , C07D207/06 , C07D263/04
CPC分类号： B01J31/2273 , C07C209/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/16 , C07D209/54 , C07D211/16 , C07D263/04 , C07D263/06 , C07F15/025 , C07C211/40 , C07C211/38 , C07C211/41
摘要： The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a FeII-dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
摘要翻译： 本发明提供了通过使叠氮化物与含有一个或多个C-H基团的化合物反应，由FeII-二吡咯亚甲基络合物催化制备无环仲胺的新型合成方法。 认为无环仲胺是通过分子间硝基转移而形成的。 本文还提供了通过使含有一个或多个C-H的叠氮化物反应合成受保护（例如，Boc-或Fmoc保护的）环状仲胺（例如，5-，6-和7-元环状仲胺）的方法 基团，由FeII-二吡咯亚甲基络合物催化。 保护的环状仲胺被认为是通过分子内的nitrene转移形成的，随后可以去保护以产生环状仲胺。
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5.发明授权公开(公告)号：US09061961B2
公开(公告)日：2015-06-23
申请号：US13383321
申请日：2010-07-08
IPC分类号： C07C209/02 , C25B3/00
CPC分类号： C07C209/02 , C25B3/00 , Y02P20/582 , C07C211/46
摘要： Process for the direct amination of hydrocarbons to aminohydrocarbons, which comprises the steps: a) reaction of a feed stream E comprising at least one hydrocarbon and at least one aminating reagent to form a reaction mixture R comprising aminohydrocarbons and hydrogen and b) electrochemical separation of at least part of the hydrogen formed in the reaction from the reaction mixture R by means of a gastight membrane-electrode assembly having at least one selectively proton-conducting membrane and at least one electrode catalyst on each side of the membrane, where at least part of the hydrogen is oxidized to protons over the anode catalyst on the retentate side of the membrane and the protons are, after passing through the membrane, b1) reduced to hydrogen and/or b2) reacted with oxygen from an oxygen-comprising stream O which is brought into contact with the permeate side of the membrane to form water over the cathode catalyst on the permeate side.
摘要翻译： 用于将烃直接胺化成氨基烃的方法，其包括以下步骤：a）包含至少一种烃和至少一种氨化试剂的进料流E的反应以形成包含氨基烃和氢的反应混合物R和b）电化学分离 通过具有至少一个选择性质子传导膜和在膜的每一侧上的至少一个电极催化剂的气密膜 - 电极组件在反应混合物R的反应中形成的至少一部分氢，其中至少部分 的氢被氧化成在膜的滞留侧上的阳极催化剂上的质子，并且质子在通过膜之后，b1）还原为氢和/或b2）与来自含氧流O的氧反应，其中 与膜的渗透侧接触以在渗透侧的阴极催化剂上形成水。
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6.发明申请公开(公告)号：US20120107707A1
公开(公告)日：2012-05-03
申请号：US13383014
申请日：2010-07-07
IPC分类号： H01M8/06
CPC分类号： C07C209/02 , B01D2255/00 , B01D2256/16 , B01D2257/108 , C25B3/00 , Y02P20/582 , C07C211/46
摘要： Process for the direct amination of hydrocarbons to aminohydrocarbons by reaction of a feed stream E comprising at least one hydrocarbon and at least one aminating reagent to form a reaction mixture R comprising aminohydrocarbon and hydrogen in a reaction zone RZ and electrochemical separation of at least part of the hydrogen formed in the reaction from the reaction mixture R by means of a gastight membrane-electrode assembly having at least one selectively proton-conducting membrane and at least one electrode catalyst on each side of the membrane, where at least part of the hydrogen is oxidized to protons at the anode catalyst on the retentate side of the membrane and the protons pass through the membrane and on the permeate side are reacted with oxygen to form water, where the oxygen originates from an oxygen-comprising stream O which is brought into contact with the permeate side of the membrane, over the cathode catalyst.
摘要翻译： 通过包含至少一种烃和至少一种氨化试剂的进料流E的反应将碳氢化合物直接胺化成氨基烃的方法，以在反应区RZ中形成包含氨基烃和氢的反应混合物R，并且将至少部分 通过具有至少一个选择性质子传导膜和至少一个电极催化剂的气密膜电极组件在反应混合物R的反应中形成的氢，其中至少部分氢是 在阳极催化剂上在膜的滞留侧氧化成质子，并且质子通过膜并且在渗透侧与氧气反应以形成水，其中氧源自与氧接触的含氧物流O 与膜的渗透侧在阴极催化剂上。
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公开(公告)号：US20090156864A1
公开(公告)日：2009-06-18
申请号：US12379317
申请日：2009-02-19
IPC分类号： C07C209/60
CPC分类号： C07C209/60 , C07C209/02 , C07C213/02 , C07C217/84
摘要： The invention teaches novel process steps for the rapid high yield manufacture of diphenylamines of the formula wherein R1 is selected from hydrogen, alkyl, and aryl; wherein each R2 and R3 is the same or different and each is independently selected from hydrogen, alkyl, alkoxy, aralkyl, dialkylamino, alkylarylamino and substituted or unsubstituted aryl, the substituents on aryl being each independently selected from alkyl (C1-C8), alkoxy (C1-C8), aroxy, aralkoxy and halogen; wherein n and m are each independently an integer from 1 to 5. Diphenylamines are key intermediates for the production of leuco dyes used in pressure-sensitive and heat-sensitive imaging systems. The process in at least one embodiment comprises reacting at elevated temperature an aryl halide with an aromatic amine in an organic solvent and aqueous alkaline solution and optionally in some embodiments, phase-transfer agent, followed by addition of catalytic amounts of bis[tri(t-butylphosphine)]palladium at a suitable temperature to rapidly form diphenylamine.
摘要翻译： 本发明教导了用于快速高产率制备下式的二苯胺的新方法步骤：其中R 1选自氢，烷基和芳基; 其中每个R 2和R 3相同或不同，各自独立地选自氢，烷基，烷氧基，芳烷基，二烷基氨基，烷基芳基氨基和取代或未取代的芳基，芳基上的取代基各自独立地选自烷基（C1-C8），烷氧基 （C1-C8），芳氧基，芳烷氧基和卤素; 其中n和m各自独立地为1至5的整数。二苯胺是用于生产用于压敏和热敏成像系统的无色染料的关键中间体。 在至少一个实施方案中的方法包括在升高的温度下将芳基卤化物与芳族胺在有机溶剂和碱性水溶液中以及任选的一些实施方案中相转移剂反应，然后加入催化量的双[三 - 丁基膦）]钯，以快速形成二苯胺。
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公开(公告)号：US06953866B2
公开(公告)日：2005-10-11
申请号：US10769365
申请日：2004-01-30
IPC分类号： C07C209/02 , C07C209/40 , C07C213/00 , C07C209/18
CPC分类号： C07C209/02 , C07C209/40 , C07C213/00
摘要： A process is disclosed for preparing ortho substituted phenylamines comprising contacting phenylhydroxylamine, optionally substituted with at least one inert substituent, with a nucleophilic reagent in the presence of a manganese oxide at a temperature between about 10° C. and about 170° C. and a pressure from subatmospheric to superatmospheric such that an ortho substituted phenylamine, optionally correspondingly substituted with at least one inert substituent, is predominantly formed.
摘要翻译： 公开了用于制备邻位取代的苯基胺的方法，包括在约10℃至约170℃的温度下，在氧化锰存在下，将任选被至少一个惰性取代基取代的苯基羟胺与亲核试剂接触， 压力从低于大气压到高于大气压，使得主要形成任选相应地被至少一个惰性取代基取代的邻位取代的苯胺。
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公开(公告)号：US20010020115A1
公开(公告)日：2001-09-06
申请号：US09785497
申请日：2001-02-20
IPC分类号： C07C29/02
CPC分类号： C07C209/02
摘要： Process for the production of an aromatic amine by reacting an aromatic hydrocarbon with ammonia at a temperature of less than 500null C. and a pressure of less than 10 bara in the presence of a catalyst comprising at least one metal selected from the group consisting of the transition elements, lanthanides and actinides, preferably in the presence of an oxidant.
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公开(公告)号：US06204411B1
公开(公告)日：2001-03-20
申请号：US09137974
申请日：1998-08-21
IPC分类号： C07C20900
CPC分类号： C07C209/02
摘要： Process for the production of an aromatic amine by reacting an aromatic hydrocarbon with ammonia at a temperature of less than 500° C. and a pressure of less than 10 bara in the presence of a catalyst comprising at least one metal selected from the group consisting of the transition elements, lanthanides and actinides, preferably in the presence of an oxidant.
摘要翻译： 在包含至少一种选自以下的金属的催化剂存在下，在低于500℃的温度和小于10巴的温度下使芳族烃与氨反应生产芳族胺的方法。 过渡元素，镧系元素和锕系元素，优选在氧化剂的存在下。
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