公开(公告)号：US20240360071A1

公开(公告)日：2024-10-31

申请号：US18386906

申请日：2023-11-03

申请人： Orphalan S.A.

发明人： Timothy James Morley ,  Ronnie Maxwell Lawrence ,  Naseem Amin

IPC分类号： C07C211/14 ,  A61K9/00 ,  C07C209/84

CPC分类号： C07C211/14 ,  C07C209/84 ,  A61K9/0053 ,  C07B2200/13

摘要： The present invention describes a new crystalline form of triethylenetetramine tetrachloride which has improved room temperature stability over known forms and over the dichloride salt. The new crystalline form is characterised by having peaks in an XRPD spectrum at 22.9, 25.4, 25.8, 26.6, 34.6 and 35.3±0.1° 2θ and Raman shifts 943, 1173, 1527 and 1612±5 cm−1. The crystalline form of triethylenetetramine tetrachloride is useful in the treatment of Wilson's disease.

公开(公告)号：US11730167B2

公开(公告)日：2023-08-22

申请号：US17303573

申请日：2021-06-02

申请人： ECOLAB USA INC.

发明人： Erik C. Olson ,  Carter M. Silvernail ,  Gregory G. Griese

IPC分类号： A01N33/04 ,  C11D17/00 ,  C10M105/30 ,  C11D7/32 ,  C11D7/26 ,  C10M105/00 ,  C10M105/26 ,  C07C209/68 ,  C07C211/14 ,  A01N25/12 ,  A01N25/30 ,  A61L2/23 ,  C10M141/06 ,  C11D3/20 ,  C11D3/30 ,  C11D3/386 ,  C11D3/48 ,  C10N50/08

CPC分类号： A01N33/04 ,  A01N25/12 ,  A01N25/30 ,  A61L2/23 ,  C07C209/68 ,  C07C211/14 ,  C10M105/00 ,  C10M105/26 ,  C10M105/30 ,  C10M141/06 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/30 ,  C11D3/38627 ,  C11D3/48 ,  C11D7/265 ,  C11D7/3209 ,  C11D17/0047 ,  C11D17/0052 ,  C10M2207/123 ,  C10M2207/124 ,  C10M2207/127 ,  C10M2207/1233 ,  C10M2207/1273 ,  C10M2207/142 ,  C10M2207/144 ,  C10M2207/1423 ,  C10M2207/1443 ,  C10M2215/04 ,  C10M2215/041 ,  C10N2050/08 ,  C12Y301/01 ,  A01N33/04 ,  A01N25/12 ,  A01N25/30 ,  C07C209/68 ,  C07C211/14

摘要： Stable, solid triamine compositions are disclosed. The pressed, cast, extruded or other solid compositions are suitable for antimicrobial, sanitizing and disinfectant applications. Ready-to-use solutions are obtained by dissolving the solid triamine compositions with water and the methods of use thereof are particularly suitable for cleaning, disinfecting, sanitizing, rinsing and/or lubricating. Beneficially, the solid triamine compositions are at least partially neutralized, allowing activity of 90% and greater of the biocidal triamine, and provide at least substantially similar or superior performance and micro efficacy to liquid formulations.

公开(公告)号：US20190039994A1

公开(公告)日：2019-02-07

申请号：US16074494

申请日：2017-02-10

申请人： Akzo Nobel Chemicals International B.V.

发明人： Rolf Krister EDVINSSON ,  Eike Nicolas KANTZER ,  Per Fredrik Olmo LARSSON ,  Karl Fredrik LAKE ,  Antoon Jacob Berend TEN KATE ,  Ulf SCHRÖDER ,  Johan Salman MALMBERG

IPC分类号： C07C209/62

CPC分类号： C07C209/62 ,  C07C211/14 ,  C07C211/18 ,  C07D233/36

摘要： The present invention relates to a process to convert cyclic alkylene ureas into their corresponding alkylene amines wherein the process is performed by reaction with an amine compound, and wherein the amine compound comprises a primary amine, a cyclic secondary amine or a tertiary bicyclic amine.

公开(公告)号：US20170079266A1

公开(公告)日：2017-03-23

申请号：US15267363

申请日：2016-09-16

申请人： Ecolab USA Inc.

发明人： Erik C. Olson ,  Carter M. Silvernail ,  Gregory G. Griese

IPC分类号： A01N33/04 ,  A61L2/23 ,  A01N25/12 ,  C10M141/06 ,  C11D3/30 ,  C11D3/386 ,  C11D3/20 ,  C11D17/00 ,  A01N25/30 ,  C11D3/48

CPC分类号： A01N33/04 ,  A01N25/12 ,  A01N25/30 ,  A61L2/23 ,  C07C209/68 ,  C07C211/14 ,  C10M105/00 ,  C10M105/26 ,  C10M105/30 ,  C10M141/06 ,  C10M2207/123 ,  C10M2207/1233 ,  C10M2207/124 ,  C10M2207/127 ,  C10M2207/1273 ,  C10M2207/142 ,  C10M2207/1423 ,  C10M2207/144 ,  C10M2207/1443 ,  C10M2215/04 ,  C10M2215/041 ,  C10N2250/08 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/30 ,  C11D3/38627 ,  C11D3/48 ,  C11D7/265 ,  C11D7/3209 ,  C11D17/0047 ,  C11D17/0052 ,  C12Y301/01

摘要： Stable, solid triamine compositions are disclosed. The pressed, cast, extruded or other solid compositions are suitable for antimicrobial, sanitizing and disinfectant applications. Ready-to-use solutions are obtained by dissolving the solid triamine compositions with water and the methods of use thereof are particularly suitable for cleaning, disinfecting, sanitizing, rinsing and/or lubricating. Beneficially, the solid triamine compositions are at least partially neutralized, allowing activity of 90% and greater of the biocidal triamine, and provide at least substantially similar or superior performance and micro efficacy to liquid formulations.

公开(公告)号：US20170079265A1

公开(公告)日：2017-03-23

申请号：US15267508

申请日：2016-09-16

申请人： Ecolab USA Inc.

发明人： Erik C. Olson ,  Carter M. Silvernail ,  Gregory G. Griese

IPC分类号： A01N25/22 ,  A01N33/04 ,  A01N25/12 ,  A01N63/00

CPC分类号： A01N25/22 ,  A01N25/12 ,  A01N33/04 ,  A01N63/00 ,  C07C209/00 ,  C07C209/68 ,  C10M105/00 ,  C10M105/58 ,  C10M2215/041 ,  C10N2230/16 ,  C11D3/2082 ,  C11D3/48 ,  C11D7/265 ,  C11D7/3209 ,  C11D11/0023 ,  C12Y301/01003 ,  C07C211/14

摘要： Methods of making triamine solids are disclosed. Solids including free-flowing powders, to pressed, cast, extruded or other solids are disclosed. Compositions employing the solid triamines are provided and methods of use thereof are particularly suitable for cleaning, disinfecting, sanitizing, rinsing and/or lubricating are disclosed.

公开(公告)号：US09241888B2

公开(公告)日：2016-01-26

申请号：US14417598

申请日：2013-07-26

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Ralf Paus ,  Anna Benedusi ,  Barbara Marzani ,  Sergio Baroni

IPC分类号： A01N33/02 ,  C07C211/00 ,  A61K8/41 ,  A61Q7/00 ,  A61K31/132 ,  C07C211/14

CPC分类号： A61K8/41 ,  A61K31/132 ,  A61Q7/00 ,  C07C211/14

摘要： The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R—N1-spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N1—R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

摘要翻译： 本发明涉及一种用于治疗脱发的化妆品或药物组合物，通常用于抵消过度脱发，其包含作为活性成分的式（I）化合物R-N1-亚精胺或1,4-丁烷二胺， N-（3-氨基丙基）-N1-R。 通式（I）的化合物根据本发明的目的是有活性的，并且也足够稳定以允许有效应用于头皮上的局部使用，而不会潜在地转化为不再活化的不同物质，如 氧化的结果。

公开(公告)号：US20150329474A1

公开(公告)日：2015-11-19

申请号：US14708515

申请日：2015-05-11

申请人： CANON KABUSHIKI KAISHA

发明人： Taichi Shintou ,  Kazuhiro Yamauchi ,  Satoru Nishioka ,  Takeshi Miyazaki

IPC分类号： C07C211/63 ,  H01B1/12 ,  C09J175/08 ,  G02B1/04 ,  C07C311/48 ,  C09D175/08

CPC分类号： H01B1/20 ,  C07C211/13 ,  C07C211/14 ,  C07C211/18 ,  C07C211/63 ,  C07C311/09 ,  C07C311/10 ,  C07C311/48 ,  C07D213/18 ,  C07D233/61 ,  C07D285/15 ,  C07D295/13 ,  C08G18/3268 ,  C08G18/4081 ,  C08G18/48 ,  C08G18/6423 ,  H01B1/122

摘要： An amine compound and an ionic conductive agent excellent in electroconductivity are provided. By using the amine compound, an electroconductive resin composition suppressed in bleeding and excellent in electroconductivity is provided. The amine compound and the ionic conductive agent have a structure represented by the following general formula (1).

摘要翻译： 提供了导电性优异的胺化合物和离子导电剂。 通过使用胺化合物，提供抑制渗血性和导电性优异的导电性树脂组合物。 胺化合物和离子导电剂具有由以下通式（1）表示的结构。

公开(公告)号：US09149531B2

公开(公告)日：2015-10-06

申请号：US14178534

申请日：2014-02-12

申请人： AXOLABS GMBH

发明人： Rainer Constien ,  Anke Geick ,  Philipp Hadwiger ,  Torsten Haneke ,  Ludger Markus Ickenstein ,  Carla Alexandra Hernandez Prata ,  Andrea Schuster ,  Timo Weide

IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  A61K47/18 ,  C07C211/14 ,  C07C217/08 ,  C07C217/28 ,  A61K9/127 ,  B82Y5/00 ,  C07D241/04 ,  A61K9/14 ,  A61K31/70 ,  A61K38/02 ,  C07C211/11 ,  C07C211/13 ,  C07C211/22 ,  C07C217/42 ,  A61K31/575 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/22 ,  C07D295/30 ,  A61K39/00

CPC分类号： A61K9/145 ,  A61K9/1271 ,  A61K31/575 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/02 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  B82Y5/00 ,  C07C211/11 ,  C07C211/13 ,  C07C211/14 ,  C07C211/22 ,  C07C217/08 ,  C07C217/28 ,  C07C217/42 ,  C07D241/04 ,  C07D295/13 ,  C07D295/30

摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

摘要翻译： 本发明提供新的氨基脂质，包含这种氨基脂质的组合物及其制备方法。 此外，提供了包含新型氨基脂质和生物活性化合物的脂质纳米粒子，以及生产方法及其用于细胞内药物递送。

公开(公告)号：US09133098B2

公开(公告)日：2015-09-15

申请号：US14506076

申请日：2014-10-03

申请人： Nippon Soda Co., Ltd.

发明人： Hiroki Inoue

IPC分类号： C07C215/00 ,  C07C211/00 ,  C07C217/08 ,  C07F1/02 ,  C07F5/02 ,  C07C211/14

CPC分类号： C07C217/08 ,  C07C211/14 ,  C07F1/02 ,  C07F5/025

摘要： A method for producing an organolithium compound includes the step of reacting an aromatic compound or a halogenated unsaturated aliphatic compound and a lithiating agent in the presence of a coordinating compound containing three or more elements having a coordinating ability in a molecule, at least one thereof being a nitrogen element, or a coordinating compound containing three or more oxygen elements having a coordinating ability in a molecule, at least one of the groups containing the oxygen elements having a coordinating ability being a tertiary alkoxy group, at a temperature of −40° C. to 40° C.

摘要翻译： 有机锂化合物的制造方法包括使芳香族化合物或卤化不饱和脂肪族化合物与锂化剂在含有分子中具有配位能力的三种以上的配位化合物的存在下反应的工序，其中至少一个为 氮元素或含有三个或更多个在分子中具有配位能力的氧元素的配位化合物，至少一个含有具有叔烷氧基的配位能力的氧元素的基团在-40℃的温度下 至40℃

公开(公告)号：US20150050295A9

公开(公告)日：2015-02-19

申请号：US14178534

申请日：2014-02-12

申请人： AXOLABS GMBH

发明人： RAINER CONSTIEN ,  ANKE GEICK ,  PHILIPP HADWIGER ,  TORSTEN HANEKE ,  LUDGER MARKUS ICKENSTEIN ,  CARLA ALEXANDRA HERNANDEZ PRATA ,  ANDREA SCHUSTER ,  TIMO WEIDE

IPC分类号： A61K47/18 ,  A61K39/00 ,  A61K31/7088

CPC分类号： A61K9/145 ,  A61K9/1271 ,  A61K31/575 ,  A61K31/70 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/02 ,  A61K39/00 ,  A61K47/18 ,  A61K47/22 ,  B82Y5/00 ,  C07C211/11 ,  C07C211/13 ,  C07C211/14 ,  C07C211/22 ,  C07C217/08 ,  C07C217/28 ,  C07C217/42 ,  C07D241/04 ,  C07D295/13 ,  C07D295/30

摘要： The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

摘要翻译： 本发明提供新的氨基脂质，包含这种氨基脂质的组合物及其制备方法。 此外，提供了包含新型氨基脂质和生物活性化合物的脂质纳米粒子，以及生产方法及其用于细胞内药物递送。