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84 条记录 (耗时 0.032 秒)

    Ionic liquids and process for manufacturing the same
    7.
    发明授权
    Ionic liquids and process for manufacturing the same 有权
    离子液体及其制造方法

    公开(公告)号：US07465834B2

    公开(公告)日：2008-12-16

    申请号：US11005708

    申请日：2004-12-07

    申请人： Kumiko Sueto ,  Miyuki Kasahara ,  Osamu Omae ,  Yuan Gao

    发明人： Kumiko Sueto ,  Miyuki Kasahara ,  Osamu Omae ,  Yuan Gao

    IPC分类号： C07C211/01

    CPC分类号： C07C217/42 ,  C07C311/48 ,  H01G9/2009 ,  H01M6/162 ,  H01M2300/0022 ,  Y02E10/542 ,  Y02E60/13 ,  Y02P70/521

    摘要： Ionic liquids exhibit a stable liquid state even at low temperatures and have a good conductivity. The ionic liquids each contain an organic compound represented by the following formula (1) as a cation. In the formula, R1 to R5 may be the same as or different from each other and each represents an H, a halogen, or a C1 to C10 alkyl group, cycloalkyl group, heterocyclic group, aryl group or alkoxyalkyl group; X and Y may be the same as or different from each other and each represents an N or a P; Z represents an S or an O.

    摘要翻译： 即使在低温下，离子液体表现出稳定的液体状态，并具有良好的导电性。 离子液体各自含有下式（1）表示的有机化合物作为阳离子。 在该式中，R 1至R 5可以相同或不同，各自表示H，卤素或C 1至C 10烷基，环烷基，杂环基，芳基或烷氧基烷基; X和Y可以相同或不同，并且各自表示N或P; Z表示S或O.

    Cytofectin dimers and methods of use thereof
    9.
    发明授权
    Cytofectin dimers and methods of use thereof 失效
    细胞分裂素二聚体及其使用方法

    公开(公告)号：US06696424B1

    公开(公告)日：2004-02-24

    申请号：US09580463

    申请日：2000-05-26

    申请人： Carl Wheeler

    发明人： Carl Wheeler

    IPC分类号： A01N6100

    CPC分类号： C07C237/08 ,  A61K9/1272 ,  A61K39/39 ,  C07C217/42 ,  C07C275/14 ,  C12N15/88

    摘要： A composition is provided comprising a novel cationic lipid compound having hydrophobic tails and two quaternary ammonium headgroups bridged by a linker. The composition is useful as a cytofectin for facilitating delivery and transfection of biologically active agents, particularly anionic bioactive agents such as DNA, into cells. The composition is useful also as an adjuvant for enhancing the humoral immune response of a vertebrate to an immunogen, especially an immunogen encoded by a polynucleotide-based vaccine. In certain preferred embodiments, the cationic lipid compound is a dimer containing quaternary ammonium headgroups bridged by a linker having DNA and/or cell receptor binding affinity, such as a polypeptide or polyamine. Also disclosed is an immunogenic composition comprising an immunogen and the composition of the present invention.

    摘要翻译： 提供了一种组合物，其包含具有疏水尾部的新型阳离子脂质化合物和由接头桥连的两个季铵头基。 该组合物可用作细胞促进剂，用于促进生物活性剂（特别是阴离子生物活性剂如DNA）的递送和转染到细胞中。 该组合物还可用作增强脊椎动物免疫原的体液免疫应答的佐剂，特别是由基于多核苷酸的疫苗编码的免疫原。 在某些优选实施方案中，阳离子脂质化合物是含有由具有DNA和/或细胞受体结合亲和力的接头如多肽或多胺桥接的季铵头基的二聚体。 还公开了包含免疫原和本发明组合物的免疫原性组合物。

    Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes
    10.
    发明授权
    Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes 失效
    多功能阳离子细胞增生素，用于产生活性细胞色素的制剂和方法：多核苷酸转染复合物

    公开(公告)号：US5824812A

    公开(公告)日：1998-10-20

    申请号：US710350

    申请日：1996-09-17

    申请人： Michael H. Nantz ,  Michael J. Bennett ,  Rajiv P. Balasubramaniam ,  Alfred M. Aberle ,  Robert W. Malone

    发明人： Michael H. Nantz ,  Michael J. Bennett ,  Rajiv P. Balasubramaniam ,  Alfred M. Aberle ,  Robert W. Malone

    IPC分类号： A61K9/127 ,  A61K47/48 ,  C07C217/28 ,  C07C217/42 ,  C07C219/06 ,  C07C219/08 ,  C07H21/00 ,  C07C101/00

    CPC分类号： C07H21/00 ,  A61K47/48023 ,  A61K47/48046 ,  A61K9/1272 ,  C07C217/28 ,  C07C217/42 ,  C07C219/06 ,  C07C219/08

    摘要： Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that have the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of same or different lipoyl moieties selected from a group consisting of an alkyl, alkenyl, alkynyl, alkanoyl, alkenoyl, or alkynoyl groups and for R.sub.1, R.sub.2, and R.sub.3 at least two are hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl groups or at least one amine bonded halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group or a mixture of at least one halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group and at least one hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl group, and X.sup.- is an oxyanion or halide counterion or ##STR2## wherein a, b, or d are the same or different and are from 0-10, usually between 0 and 3, preferably 0 or 1; R.sub.4 and R.sub.5 are the same or different with each an alkyl group, an alkenyl group, an alkynyl group, or an alkyl, alkenyl, or alkynyl containing acyl group; R.sub.8, R.sub.9, or R.sub.10 are the same or different with each an alkyl, alkenyl, or alkynyl group or halogenated alkyl, alkenyl, or alkynyl group as long as one is halogen containing; and X.sup.- is an anion, usually an oxyanion or halide counterion.

    摘要翻译： 含胺化合物及其在产生细胞分裂素中的用途：用于转染细胞的多核苷酸复合物，制剂，抗衡离子和用于使转染最大化的反应条件包括使用具有以下通用结构的阳离子胺化合物：其中R 4和R 5为 一对相同或不同的选自烷基，烯基，炔基，烷酰基，烯酰基或炔酰基的脂酰基部分，对于R1，R2和R3至少两个是羟基化的，含醚的或含酰氧基的烷基，烯基 ，或炔基或至少一个与胺键合的含卤素的部分，其选自卤代烷基，烯基或炔基，或至少一种含卤素部分的混合物，所述部分选自卤代烷基，烯基， 或炔基和至少一个羟基化的含醚或含酰氧基的烷基，烯基或炔基，X是氧阴离子或卤化物 其中a，b或d相同或不同，为0-10，通常为0至3，优选为0或1; R4和R5与烷基，烯基，炔基或含酰基的烷基，链烯基或炔基相同或不同; R8，R9或R10与烷基，烯基或炔基或卤代烷基，烯基或炔基相同或不同，只要一个为含卤素; X-是阴离子，通常是氧阴离子或卤离子抗衡离子。